ID   TMD8
AC   CVCL_A442
SY   TMD-8; Tokyo Medical and Dental university 8
DR   EFO; EFO_0006496
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-4956
DR   BioGRID_ORCS_Cell_line; 748
DR   cancercelllines; CVCL_A442
DR   ChEMBL-Cells; CHEMBL4295480
DR   ChEMBL-Targets; CHEMBL4296503
DR   Cosmic; 1486587
DR   Cosmic; 1945194
DR   Cosmic; 2129635
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001002554
DR   GEO; GSM1059801
DR   GEO; GSM1374963
DR   GEO; GSM1527304
DR   GEO; GSM1527305
DR   GEO; GSM1527306
DR   GEO; GSM1527307
DR   GEO; GSM1527308
DR   GEO; GSM1527309
DR   GEO; GSM1890021
DR   GEO; GSM1890022
DR   GEO; GSM1890023
DR   GEO; GSM1890024
DR   GEO; GSM2037048
DR   GEO; GSM2037049
DR   PharmacoDB; TMD8_1600_2019
DR   Progenetix; CVCL_A442
DR   PubChem_Cell_line; CVCL_A442
DR   Wikidata; Q54972694
RX   PubMed=16780947;
RX   PubMed=20054396;
RX   PubMed=21179087;
RX   PubMed=23257783;
RX   PubMed=23292937;
RX   PubMed=25485619;
RX   PubMed=26589293;
RX   PubMed=26787899;
RX   PubMed=27566572;
RX   PubMed=29416618;
RX   PubMed=29666304;
CC   Population: Japanese.
CC   Characteristics: Genetically heterogeneous, consists of 3 subclones (PubMed=27566572).
CC   Doubling time: ~30 hours (PubMed=16780947).
CC   HLA typing: A*02:07,02:07; B*15:01,46:01; C*01:02,01:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:1699; CD79B; Simple; p.Tyr196His (c.586T>C); Zygosity=Heterozygous (PubMed=20054396).
CC   Sequence variation: Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (PubMed=21179087).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Miscellaneous: STR profile from personal communication of Gachova, Daniela.
CC   Misspelling: TDM8; PubMed=23292937.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 9,11,12
ST   D16S539: 9,11
ST   D18S51: 13,20
ST   D19S433: 12.2,13.2
ST   D21S11: 30
ST   D2S1338: 17,23
ST   D3S1358: 17,18
ST   D5S818: 12,13
ST   D7S820: 8,10
ST   D8S1179: 10,14
ST   FGA: 17,23
ST   TH01: 6,7
ST   TPOX: 11
ST   vWA: 14,18
DI   NCIt; C36081; Diffuse large B-cell lymphoma activated B-cell type
DI   ORDO; Orphanet_544; Diffuse large B-cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 14-08-25; Version: 33
CH   CVCL_E8IZ ! TMD8-BTK-A428D-KI-1B4
CH   CVCL_E8J0 ! TMD8-BTK-C481F-KI
CH   CVCL_E8J1 ! TMD8-BTK-C481S-KI-1B3
CH   CVCL_E8J2 ! TMD8-BTK-C481S-KI-1C6
CH   CVCL_E8J3 ! TMD8-BTK-C481Y-KI-1A2
CH   CVCL_E8J4 ! TMD8-BTK-C481Y-KI-1B2
CH   CVCL_E8J5 ! TMD8-BTK-HiBiT-KI-1B1
CH   CVCL_E8J6 ! TMD8-BTK-L528W-KI
CH   CVCL_E8J7 ! TMD8-BTK-T474I-KI-1A1
CH   CVCL_E8J8 ! TMD8-BTK-T474I-KI-1C1
CH   CVCL_E8J9 ! TMD8-BTK-V416L-KI-1A3
CH   CVCL_E8JA ! TMD8-BTK-V416L-KI-1B1
CH   CVCL_E8GT ! TMD8-Luc2
//
RX   PubMed=27566572; DOI=10.18632/oncotarget.11524; PMCID=PMC5325377;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Ammerpohl, Ole
RA   Geffers, Robert
RA   Hauer, Vivien
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Romani, Julia
RA   Rosati, Emanuela
RA   Rosen, Anders
RA   Uphoff, Cord C.
RA   Zaborski, Margarete
RA   Drexler, Hans Gunther
RT   "Subclones in B-lymphoma cell lines: isogenic models for the study of
RT   gene regulation.";
RL   Oncotarget 7:63456-63465(2016).
//
RX   PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051;
RA   Zhang, Jenny
RA   Grubor, Vladimir
RA   Love, Cassandra L.
RA   Banerjee, Anjishnu
RA   Richards, Kristy L.
RA   Mieczkowski, Piotr Andrzej
RA   Dunphy, Cherie
RA   Choi, William Wai-Lap
RA   Au, Wing Yan
RA   Srivastava, Gopesh
RA   Lugar, Patricia Lynne
RA   Rizzieri, David A.
RA   Lagoo, Anand S.
RA   Bernal-Mizrachi, Leon
RA   Mann, Karen P.
RA   Flowers, Christopher Robert
RA   Naresh, Kikkeri N.
RA   Evens, Andrew M.
RA   Gordon, Leo I.
RA   Czader, Magdalena Beata
RA   Gill, Javed Iqbal
RA   Hsi, Eric Darryl
RA   Liu, Qing-Quan
RA   Fan, Alice
RA   Walsh, Katherine
RA   Jima, Dereje
RA   Smith, Lisa L.
RA   Johnson, Amy J.
RA   Byrd, John C.
RA   Luftig, Micah Alan
RA   Ni, Ting
RA   Zhu, Jun
RA   Chadburn, Amy
RA   Levy, Shawn
RA   Dunson, David Brian
RA   Dave, Sandeep S.
RT   "Genetic heterogeneity of diffuse large B-cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).
//
RX   PubMed=21179087; DOI=10.1038/nature09671; PMCID=PMC5024568;
RA   Ngo, Vu N.
RA   Young, Ryan M.
RA   Schmitz, Roland
RA   Jhavar, Sameer
RA   Xiao, Wen-Ming
RA   Lim, Kian-Huat
RA   Kohlhammer, Holger
RA   Xu, Wei-Hong
RA   Yang, Yan-Dan
RA   Zhao, Hong
RA   Shaffer, Arthur L. 3rd
RA   Romesser, Paul Bernard
RA   Wright, George
RA   Powell, John I.
RA   Rosenwald, Andreas
RA   Muller-Hermelink, Hans-Konrad
RA   Ott, German
RA   Gascoyne, Randy D.
RA   Connors, Joseph M.
RA   Rimsza, Lisa M.
RA   Campo, Elias
RA   Jaffe, Elaine Sarkin
RA   Delabie, Jan
RA   Smeland, Erlend Bremertun
RA   Fisher, Richard I.
RA   Braziel, Rita Merle
RA   Tubbs, Raymond Roy
RA   Cook, James R.
RA   Weisenburger, Dennis D.
RA   Chan, Wing-Chung
RA   Staudt, Louis Michael
RT   "Oncogenically active MYD88 mutations in human lymphoma.";
RL   Nature 470:115-119(2011).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=23257783; DOI=10.1038/leu.2012.367;
RA   Wenzel, Soren-Sebastian
RA   Grau, Michael
RA   Mavis, Cory
RA   Hailfinger, Stephan
RA   Wolf, Annette
RA   Madle, Hannelore
RA   Deeb, George
RA   Dorken, Bernd
RA   Thome, Margot
RA   Lenz, Peter
RA   Dirnhofer, Stefan
RA   Hernandez-Ilizaliturri, Francisco Javier
RA   Tzankov, Alexandar
RA   Lenz, Georg
RT   "MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.";
RL   Leukemia 27:1381-1390(2013).
//
RX   PubMed=16780947; DOI=10.1016/j.leukres.2006.05.003;
RA   Tohda, Shuji
RA   Sato, Taku
RA   Kogoshi, Hanae
RA   Fu, Lu
RA   Sakano, Seiji
RA   Nara, Nobuo
RT   "Establishment of a novel B-cell lymphoma cell line with suppressed
RT   growth by gamma-secretase inhibitors.";
RL   Leuk. Res. 30:1385-1390(2006).
//
RX   PubMed=29416618; DOI=10.18632/oncotarget.20378; PMCID=PMC5787470;
RA   Liu, Wei
RA   Chen, Juan
RA   Tamayo, Archito T.
RA   Ruan, Chang-Geng
RA   Li, Li
RA   Zhou, Shou-Hao
RA   Shen, Chan
RA   Young, Ken H.
RA   Westin, Jason
RA   Davis, Richard E.
RA   Hu, Shi-Min
RA   Medeiros, L. Jeffrey
RA   Ford, Richard Joseph Jr.
RA   Pham, Lan V.
RT   "Preclinical efficacy and biological effects of the oral proteasome
RT   inhibitor ixazomib in diffuse large B-cell lymphoma.";
RL   Oncotarget 9:346-360(2018).
//
RX   PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004;
RA   Pham, Lan V.
RA   Huang, Sheng-Jian
RA   Zhang, Hui
RA   Zhang, Jun
RA   Bell, Taylor
RA   Zhou, Shou-Hao
RA   Pogue, Elizabeth
RA   Ding, Zhi-Yong
RA   Lam, Laura
RA   Westin, Jason
RA   Davis, R. Eric
RA   Young, Ken H.
RA   Medeiros, L. Jeffrey
RA   Ford, Richard Joseph Jr.
RA   Nomie, Krystle
RA   Zhang, Leo
RA   Wang, Michael
RT   "Strategic therapeutic targeting to overcome venetoclax resistance in
RT   aggressive B-cell lymphomas.";
RL   Clin. Cancer Res. 24:3967-3980(2018).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=26787899; DOI=10.1073/pnas.1524677113; PMCID=PMC4747717;
RA   Dekker, Joseph D.
RA   Park, Daechan
RA   Shaffer, Arthur L. 3rd
RA   Kohlhammer, Holger
RA   Deng, Wei
RA   Lee, Bum-Kyu
RA   Ippolito, Gregory C.
RA   Georgiou, George
RA   Iyer, Vishwanath R.
RA   Staudt, Louis Michael
RA   Tucker, Haley O.
RT   "Subtype-specific addiction of the activated B-cell subset of diffuse
RT   large B-cell lymphoma to FOXP1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:E577-E586(2016).
//
RX   PubMed=20054396; DOI=10.1038/nature08638; PMCID=PMC2845535;
RA   Davis, R. Eric
RA   Ngo, Vu N.
RA   Lenz, Georg
RA   Tolar, Pavel
RA   Young, Ryan M.
RA   Romesser, Paul Bernard
RA   Kohlhammer, Holger
RA   Lamy, Laurence
RA   Zhao, Hong
RA   Yang, Yan-Dan
RA   Xu, Wei-Hong
RA   Shaffer, Arthur L. 3rd
RA   Wright, George
RA   Xiao, Wen-Ming
RA   Powell, John I.
RA   Jiang, Jian-Kang
RA   Thomas, Craig J.
RA   Rosenwald, Andreas
RA   Ott, German
RA   Muller-Hermelink, Hans-Konrad
RA   Gascoyne, Randy D.
RA   Connors, Joseph M.
RA   Johnson, Nathalie A.
RA   Rimsza, Lisa M.
RA   Campo, Elias
RA   Jaffe, Elaine Sarkin
RA   Wilson, Wyndham H.
RA   Delabie, Jan
RA   Smeland, Erlend Bremertun
RA   Fisher, Richard I.
RA   Braziel, Rita Merle
RA   Tubbs, Raymond Roy
RA   Cook, James R.
RA   Weisenburger, Dennis D.
RA   Chan, Wing-Chung
RA   Pierce, Susan Keen
RA   Staudt, Louis Michael
RT   "Chronic active B-cell-receptor signalling in diffuse large B-cell
RT   lymphoma.";
RL   Nature 463:88-92(2010).
//