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Cellosaurus MDA-MB-231-5a-D-TbetaFluc/Rluc (CVCL_9U32)

[Text version]
Cell line name MDA-MB-231-5a-D-TbetaFluc/Rluc
Synonyms MDA-231-D-TbetaFluc/Rluc; MDA-D-TbetaFluc/Rluc; 5a-D-Luc
Accession CVCL_9U32
Resource Identification Initiative To cite this cell line use: MDA-MB-231-5a-D-TbetaFluc/Rluc (RRID:CVCL_9U32)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; P27652; Renilla-type luciferase.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9U31 (MDA-MB-231-5a-D)
Children:
CVCL_9U33 (MDA-MB-231-5a-D-TbetaFluc/Rluc-ZsGreen)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=17129361; DOI=10.1111/j.1349-7006.2006.00357.x
Ehata S., Hanyu A., Fujime M., Katsuno Y., Fukunaga E., Goto K., Ishikawa Y., Nomura K., Yokoo H., Shimizu T., Ogata E., Miyazono K., Shimizu K., Imamura T.
Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line.
Cancer Sci. 98:127-133(2007)

PubMed=18663362; DOI=10.1038/onc.2008.232
Katsuno Y., Hanyu A., Kanda H., Ishikawa Y., Akiyama F., Iwase T., Ogata E., Ehata S., Miyazono K., Imamura T.
Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway.
Oncogene 27:6322-6333(2008)

PubMed=26691676; DOI=10.3892/ijo.2015.3300
Sudo H., Tsuji A.B., Sugyo A., Takuwa H., Masamoto K., Tomita Y., Suzuki N., Imamura T., Koizumi M., Saga T.
Establishment and evaluation of a new highly metastatic tumor cell line 5a-D-Luc-ZsGreen expressing both luciferase and green fluorescent protein.
Int. J. Oncol. 48:525-532(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9U32
Encyclopedic resources Wikidata; Q54904594
Entry history
Entry creation23-Feb-2016
Last entry update05-Oct-2023
Version number17