ID   MDA-MB-231-5a-D-TbetaFluc/Rluc
AC   CVCL_9U32
SY   MDA-231-D-TbetaFluc/Rluc; MDA-D-TbetaFluc/Rluc; 5a-D-Luc
DR   cancercelllines; CVCL_9U32
DR   Wikidata; Q54904594
RX   PubMed=17129361;
RX   PubMed=18663362;
RX   PubMed=26691676;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P27652; Renilla reniformis renilla-type luciferase.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9U31 ! MDA-MB-231-5a-D
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 23-02-16; Last updated: 14-08-25; Version: 20
CH   CVCL_9U33 ! MDA-MB-231-5a-D-TbetaFluc/Rluc-ZsGreen
//
RX   PubMed=17129361; DOI=10.1111/j.1349-7006.2006.00357.x; PMCID=PMC11159712;
RA   Ehata, Shogo
RA   Hanyu, Aki
RA   Fujime, Makoto
RA   Katsuno, Yoko
RA   Fukunaga, Erina
RA   Goto, Kouichiro
RA   Ishikawa, Yuichi
RA   Nomura, Kimie
RA   Yokoo, Hiroshi
RA   Shimizu, Toshiyuki
RA   Ogata, Etsuro
RA   Miyazono, Kohei
RA   Shimizu, Kiyochi
RA   Imamura, Takeshi
RT   "Ki26894, a novel transforming growth factor-beta type I receptor
RT   kinase inhibitor, inhibits in vitro invasion and in vivo bone
RT   metastasis of a human breast cancer cell line.";
RL   Cancer Sci. 98:127-133(2007).
//
RX   PubMed=26691676; DOI=10.3892/ijo.2015.3300;
RA   Sudo, Hitomi
RA   Tsuji, Atsushi B.
RA   Sugyo, Aya
RA   Takuwa, Hiroyuki
RA   Masamoto, Kazuto
RA   Tomita, Yutaka
RA   Suzuki, Norihiro
RA   Imamura, Takeshi
RA   Koizumi, Mitsuru
RA   Saga, Tsuneo
RT   "Establishment and evaluation of a new highly metastatic tumor cell
RT   line 5a-D-Luc-ZsGreen expressing both luciferase and green fluorescent
RT   protein.";
RL   Int. J. Oncol. 48:525-532(2016).
//
RX   PubMed=18663362; DOI=10.1038/onc.2008.232;
RA   Katsuno, Yoko
RA   Hanyu, Aki
RA   Kanda, Hidetoshi
RA   Ishikawa, Yuichi
RA   Akiyama, Futoshi
RA   Iwase, Takushi
RA   Ogata, Etsuro
RA   Ehata, Shogo
RA   Miyazono, Kohei
RA   Imamura, Takeshi
RT   "Bone morphogenetic protein signaling enhances invasion and bone
RT   metastasis of breast cancer cells through Smad pathway.";
RL   Oncogene 27:6322-6333(2008).
//