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Cellosaurus MDA-MB-231-5a-D (CVCL_9U31)

[Text version]
Cell line name MDA-MB-231-5a-D
Synonyms MDA-231-D
Accession CVCL_9U31
Resource Identification Initiative To cite this cell line use: MDA-MB-231-5a-D (RRID:CVCL_9U31)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9U30 (MDA-MB-231-5a)
Children:
CVCL_9U32 (MDA-MB-231-5a-D-TbetaFluc/Rluc)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=17129361; DOI=10.1111/j.1349-7006.2006.00357.x
Ehata S., Hanyu A., Fujime M., Katsuno Y., Fukunaga E., Goto K., Ishikawa Y., Nomura K., Yokoo H., Shimizu T., Ogata E., Miyazono K., Shimizu K., Imamura T.
Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line.
Cancer Sci. 98:127-133(2007)

PubMed=18663362; DOI=10.1038/onc.2008.232
Katsuno Y., Hanyu A., Kanda H., Ishikawa Y., Akiyama F., Iwase T., Ogata E., Ehata S., Miyazono K., Imamura T.
Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway.
Oncogene 27:6322-6333(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9U31
Encyclopedic resources Wikidata; Q54904593
Entry history
Entry creation23-Feb-2016
Last entry update05-Oct-2023
Version number17