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Cellosaurus UKF-NB-3 (CVCL_9904)

[Text version]
Cell line name UKF-NB-3
Synonyms UKF-NB3
Accession CVCL_9904
Resource Identification Initiative To cite this cell line use: UKF-NB-3 (RRID:CVCL_9904)
Comments Doubling time: 22 +- 1.9 hours (PubMed=16142320).
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_RT07 (UKF-NB-3rBORTE20)CVCL_RT08 (UKF-NB-3rCABAZI2)CVCL_RR89 (UKF-NB-3rCARBO2000)
CVCL_M478 (UKF-NB-3rCDDP1000)CVCL_RQ61 (UKF-NB-3rDACARB8)CVCL_RS03 (UKF-NB-3rDOCE10)
CVCL_RR90 (UKF-NB-3rDOCE20)CVCL_9906 (UKF-NB-3rDOX100)CVCL_RS04 (UKF-NB-3rDOX20)
CVCL_RR91 (UKF-NB-3rETO100)CVCL_RT09 (UKF-NB-3rETO200)CVCL_RQ62 (UKF-NB-3rGEMCI10)
CVCL_RT10 (UKF-NB-3rGEMCI20)CVCL_RQ63 (UKF-NB-3rIRINO800)CVCL_RS06 (UKF-NB-3rMEL2000)
CVCL_RQ64 (UKF-NB-3rMEL400)CVCL_RS05 (UKF-NB-3rNutlin10muM)CVCL_RQ65 (UKF-NB-3rOXALI2000)
CVCL_RT11 (UKF-NB-3rOXALI4000)CVCL_RQ66 (UKF-NB-3rPCL20)CVCL_RS21 (UKF-NB-3rRITA10muM)
CVCL_RS19 (UKF-NB-3rSNS-032_300nM)CVCL_RQ67 (UKF-NB-3rTOPO15)CVCL_RT12 (UKF-NB-3rTOPO20)
CVCL_9905 (UKF-NB-3rVCR10)CVCL_RS08 (UKF-NB-3rVCR20)CVCL_RR82 (UKF-NB-3rVINB10)
CVCL_RQ68 (UKF-NB-3rVINOR20)CVCL_RT24 (UKF-NB-3rYM155_20nM)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): PubMed=31581737

Markers:
AmelogeninX
CSF1PO10,11
D2S133816,21
D3S135815,18
D5S81811
D7S82010,11
D8S11799,10
D13S31711
D16S53913
D18S5116,18
D19S43314
D21S1129,33.2
FGA19,25
Penta D8,15
Penta E12
TH019,9.3
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Publications

CLPUB00123
Jaroslaw Cinatl, Evgenios S. Gussetis, Jindrich Cinatl Jr., Uwe Ebener, Marion Mainke, Dirk Schwabe, Hans-Wilhelm Doerr, Bernhard Kornhuber, Valentin Gerein;
Differentiation arrest in neuroblastoma cell culture.
J. Cancer Res. Clin. Oncol. 116 Suppl. 1:9-9(1990)

PubMed=8949988; DOI=10.1097/00001813-199609000-00008
Jindrich Cinatl Jr., Jaroslaw Cinatl, Martin Scholz, Pablo Hernaiz Driever, Dirk Henrich, Hanka Kabickova, Jens-Uwe Vogel, Hans-Wilhelm Doerr, Bernhard Kornhuber;
Antitumor activity of sodium valproate in cultures of human neuroblastoma cells.
Anticancer Drugs 7:766-773(1996)

PubMed=9201287
Jindrich Cinatl Jr., Pablo Hernaiz Driever, Jaroslaw Cinatl, Dieter G. Ruckert, Hermann O.C. Gumbel, Holger F. Rabenau, Bernhard Kornhuber, Hans-Wilhelm Doerr;
Increased efficacy of aphidicolin killing of human neuroblastoma cells in vitro by encapsulation in liposomes.
Neoplasma 44:91-95(1997)

PubMed=16142320; DOI=10.3892/ijo.27.4.1029
Rouslan Kotchetkov, Pablo Hernaiz Driever, Jaroslaw Cinatl, Martin Michaelis, Jana Karaskova, Roman A. Blaheta, Jeremy Andrew Squire, Andreas von Deimling, Jussi Moog, Jindrich Cinatl Jr.;
Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression.
Int. J. Oncol. 27:1029-1037(2005)

PubMed=16151587
Jiri B. Bedrnicek, Ales Vicha, Marie Jarosova, Milena Holzerova, Jindrich Cinatl Jr., Martin Michaelis, Jaroslaw Cinatl, Tomas Eckschlager;
Characterization of drug-resistant neuroblastoma cell lines by comparative genomic hybridization.
Neoplasma 52:415-419(2005)

PubMed=17505515; DOI=10.1038/sj.bjc.6603777; PMCID=PMC2359931
Roman A. Blaheta, Martin Michaelis, Iyad Natsheh, Christoph Hasenberg, Eva Weich, Borna Relja, Dietger Jonas, Hans-Wilhelm Doerr, Jindrich Cinatl Jr.;
Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium.
Br. J. Cancer 96:1699-1706(2007)

PubMed=19147553; DOI=10.1158/0008-5472.CAN-08-1856
Martin Michaelis, Florian Rothweiler, Denise Klassert, Andreas von Deimling, Kristoffer Weber, Boris Fehse, Bernd Kammerer, Hans-Wilhelm Doerr, Jindrich Cinatl Jr.;
Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.
Cancer Res. 69:416-421(2009)

PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738
Martin Michaelis, Florian Rothweiler, Susanne Barth, Jaroslaw Cinatl, Marijke van Rikxoort, Nadine Loschmann, Yvonne Voges, Rainer Breitling, Andreas von Deimling, Franz Rodel, Kristoffer Weber ...Show all 17 authors... , Boris Fehse, Elisabeth Mack, Thorsten Stiewe, Hans-Wilhelm Doerr, Daniel Speidel, Jindrich Cinatl Jr.; Show fewer authors
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.
Cell Death Dis. 2:e243.1-e243.8(2011)

PubMed=22476102; DOI=10.1038/cddis.2012.35; PMCID=PMC3358013
Martin Michaelis, Florian Rothweiler, Bishr Agha, Susanne Barth, Yvonne Voges, Nadine Loschmann, Andreas von Deimling, Rainer Breitling, Hans-Wilhelm Doerr, Franz Rodel, Daniel Speidel, Jindrich Cinatl Jr.;
Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.
Cell Death Dis. 3:e294.1-e294.8(2012)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=25749379; DOI=10.18632/oncotarget.2889; PMCID=PMC4627332
Martin Michaelis, Florian Rothweiler, Nadine Loschmann, Mohsen Sharifi, Taravat Ghafourian, Jindrich Cinatl Jr.;
Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status.
Oncotarget 6:17605-17620(2015)

PubMed=27517323; DOI=10.18632/oncotarget.11160; PMCID=PMC5295411
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Yvonne Voges, Barbora Balonova, Barry A. Blight, Jindrich Cinatl Jr.;
ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance.
Oncotarget 7:58051-58064(2016)

PubMed=27735941; DOI=10.1038/cddis.2016.257; PMCID=PMC5133961
Yvonne Voges, Martin Michaelis, Florian Rothweiler, Torsten Schaller, Constanze Schneider, Katharina Politt, Marco Mernberger, Andrea Nist, Thorsten Stiewe, Mark N. Wass, Franz Rodel, Jindrich Cinatl Jr.;
Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance.
Cell Death Dis. 7:e2410.1-e2410.11(2016)

PubMed=31581737; DOI=10.3390/cells8101194; PMCID=PMC6830094
Jane F. Povey, Emily Saintas, Adewale Victor Aderemi, Florian Rothweiler, Richard Zehner, Wilhelm Gerhard Dirks, Jindrich Cinatl Jr., Andrew J. Racher, Mark N. Wass, Christopher Mark Smales, Martin Michaelis;
Intact-cell MALDI-ToF mass spectrometry for the authentication of drug-adapted cancer cell lines.
Cells 8:1194.1-1194.12(2019)

Cross-references
Encyclopedic resources Wikidata; Q54990311
Polymorphism and mutation databases IARC_TP53; 26506
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number14