Cellosaurus cell line UKF-NB-3rNutlin10muM (CVCL

Cellosaurus UKF-NB-3rNutlin10muM (CVCL_RS05)

Cross-references
Cell line name	UKF-NB-3rNutlin10muM
Accession	CVCL_RS05
Resource Identification Initiative	To cite this cell line use: UKF-NB-3rNutlin10muM (RRID:CVCL_RS05)
Comments	Part of: Resistant Cancer Cell Line (RCCL) collection. Selected for resistance to: ChEBI; CHEBI_46742; Nutlin-3. Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Unspecified (PubMed=22170099).
Disease	Neuroblastoma (NCIt: C3270) Neuroblastoma (ORDO: Orphanet_635)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_9904 (UKF-NB-3)
Sex of cell	Female
Category	Cancer cell line
Web pages	Provider; RCCL; -; https://www.wass-michaelislab.org/rccl.php
Publications	PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738 Martin Michaelis, Florian Rothweiler, Susanne Barth, Jaroslaw Cinatl, Marijke van Rikxoort, Nadine Loschmann, Yvonne Voges, Rainer Breitling, Andreas von Deimling, Franz Rodel, Kristoffer Weber ...Show all 17 authors... , Boris Fehse, Elisabeth Mack, Thorsten Stiewe, Hans-Wilhelm Doerr, Daniel Speidel, Jindrich Cinatl Jr.; Show fewer authors Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. Cell Death Dis. 2:e243.1-e243.8(2011) PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703 Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs. Transl. Oncol. 6:685-696(2013)
Cell line databases/resources	cancercelllines; CVCL_RS05
Encyclopedic resources	Wikidata; Q54990350
Entry history
Entry creation	05-Mar-2018
Last entry update	10-Apr-2025
Version number	12