ID   UKF-NB-3rNutlin10muM
AC   CVCL_RS05
DR   cancercelllines; CVCL_RS05
DR   Wikidata; Q54990350
RX   PubMed=22170099;
RX   PubMed=24466371;
WW   Provider; RCCL; -; https://www.wass-michaelislab.org/rccl.php
CC   Part of: Resistant Cancer Cell Line (RCCL) collection.
CC   Selected for resistance to: ChEBI; CHEBI_46742; Nutlin-3.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Unspecified (PubMed=22170099).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9904 ! UKF-NB-3
SX   Female
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 10-04-25; Version: 12
//
RX   PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738;
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Barth, Susanne
RA   Cinatl, Jaroslaw
RA   van Rikxoort, Marijke
RA   Loschmann, Nadine
RA   Voges, Yvonne
RA   Breitling, Rainer
RA   von Deimling, Andreas
RA   Rodel, Franz
RA   Weber, Kristoffer
RA   Fehse, Boris
RA   Mack, Elisabeth
RA   Stiewe, Thorsten
RA   Doerr, Hans-Wilhelm
RA   Speidel, Daniel
RA   Cinatl, Jindrich Jr.
RT   "Adaptation of cancer cells from different entities to the MDM2
RT   inhibitor nutlin-3 results in the emergence of p53-mutated
RT   multi-drug-resistant cancer cells.";
RL   Cell Death Dis. 2:e243.1-e243.8(2011).
//
RX   PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703;
RA   Loschmann, Nadine
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Zehner, Richard
RA   Cinatl, Jaroslaw
RA   Voges, Yvonne
RA   Sharifi, Mohsen
RA   Riecken, Kristoffer
RA   Meyer, Jochen
RA   von Deimling, Andreas
RA   Fichtner, Iduna
RA   Ghafourian, Taravat
RA   Westermann, Frank
RA   Cinatl, Jindrich Jr.
RT   "Testing of SNS-032 in a panel of human neuroblastoma cell lines with
RT   acquired resistance to a broad range of drugs.";
RL   Transl. Oncol. 6:685-696(2013).
//