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Cellosaurus UKF-NB-2 (CVCL_9902)

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Cell line name UKF-NB-2
Synonyms UKF-NB2
Accession CVCL_9902
Resource Identification Initiative To cite this cell line use: UKF-NB-2 (RRID:CVCL_9902)
Comments Doubling time: 22.5-25.6 hours (PubMed=9443419); 25 hours (PubMed=12532417).
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_9903 (UKF-NB-2AD169)CVCL_RT20 (UKF-NB-2rCARBO2000)CVCL_9908 (UKF-NB-2rCDDP1000)
CVCL_RT02 (UKF-NB-2rDACARB4)CVCL_RR83 (UKF-NB-2rDOCE10)CVCL_9909 (UKF-NB-2rDOX100)
CVCL_RS01 (UKF-NB-2rDOX20)CVCL_RT03 (UKF-NB-2rETO40)CVCL_RT04 (UKF-NB-2rETO400)
CVCL_RT05 (UKF-NB-2rIRINO400)CVCL_RR84 (UKF-NB-2rMEL600)CVCL_RS02 (UKF-NB-2rNutlin10muM)
CVCL_RR85 (UKF-NB-2rOXALI600)CVCL_RT06 (UKF-NB-2rPCL20)CVCL_RR86 (UKF-NB-2rTOPO10)
CVCL_9910 (UKF-NB-2rVCR10)CVCL_RS00 (UKF-NB-2rVCR20)CVCL_RR87 (UKF-NB-2rVINB10)
CVCL_RR88 (UKF-NB-2rVINOR10)
Category Cancer cell line
Publications

CLPUB00123
Jaroslaw Cinatl, Evgenios S. Gussetis, Jindrich Cinatl Jr., Uwe Ebener, Marion Mainke, Dirk Schwabe, Hans-Wilhelm Doerr, Bernhard Kornhuber, Valentin Gerein;
Differentiation arrest in neuroblastoma cell culture.
J. Cancer Res. Clin. Oncol. 116 Suppl. 1:9-9(1990)

PubMed=8949988; DOI=10.1097/00001813-199609000-00008
Jindrich Cinatl Jr., Jaroslaw Cinatl, Martin Scholz, Pablo Hernaiz Driever, Dirk Henrich, Hanka Kabickova, Jens-Uwe Vogel, Hans-Wilhelm Doerr, Bernhard Kornhuber;
Antitumor activity of sodium valproate in cultures of human neuroblastoma cells.
Anticancer Drugs 7:766-773(1996)

PubMed=9201287
Jindrich Cinatl Jr., Pablo Hernaiz Driever, Jaroslaw Cinatl, Dieter G. Ruckert, Hermann O.C. Gumbel, Holger F. Rabenau, Bernhard Kornhuber, Hans-Wilhelm Doerr;
Increased efficacy of aphidicolin killing of human neuroblastoma cells in vitro by encapsulation in liposomes.
Neoplasma 44:91-95(1997)

PubMed=9443419
Jindrich Cinatl Jr., Jaroslaw Cinatl, Jens-Uwe Vogel, Rouslan Kotchetkov, Pablo Hernaiz Driever, Hanka Kabickova, Bernhard Kornhuber, Dirk Schwabe, Hans-Wilhelm Doerr;
Persistent human cytomegalovirus infection induces drug resistance and alteration of programmed cell death in human neuroblastoma cells.
Cancer Res. 58:367-372(1998)

PubMed=12532417; DOI=10.1002/ijc.10917
Rouslan Kotchetkov, Jaroslaw Cinatl, Roman A. Blaheta, Jens-Uwe Vogel, Jana Karaskova, Jeremy Andrew Squire, Pablo Hernaiz Driever, Thomas Klingebiel, Jindrich Cinatl Jr.;
Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: a preclinical model.
Int. J. Cancer 104:36-43(2003)

PubMed=16151587
Jiri B. Bedrnicek, Ales Vicha, Marie Jarosova, Milena Holzerova, Jindrich Cinatl Jr., Martin Michaelis, Jaroslaw Cinatl, Tomas Eckschlager;
Characterization of drug-resistant neuroblastoma cell lines by comparative genomic hybridization.
Neoplasma 52:415-419(2005)

PubMed=17505515; DOI=10.1038/sj.bjc.6603777; PMCID=PMC2359931
Roman A. Blaheta, Martin Michaelis, Iyad Natsheh, Christoph Hasenberg, Eva Weich, Borna Relja, Dietger Jonas, Hans-Wilhelm Doerr, Jindrich Cinatl Jr.;
Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium.
Br. J. Cancer 96:1699-1706(2007)

PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738
Martin Michaelis, Florian Rothweiler, Susanne Barth, Jaroslaw Cinatl, Marijke van Rikxoort, Nadine Loschmann, Yvonne Voges, Rainer Breitling, Andreas von Deimling, Franz Rodel, Kristoffer Weber ...Show all 17 authors... , Boris Fehse, Elisabeth Mack, Thorsten Stiewe, Hans-Wilhelm Doerr, Daniel Speidel, Jindrich Cinatl Jr.; Show fewer authors
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.
Cell Death Dis. 2:e243.1-e243.8(2011)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=25749379; DOI=10.18632/oncotarget.2889; PMCID=PMC4627332
Martin Michaelis, Florian Rothweiler, Nadine Loschmann, Mohsen Sharifi, Taravat Ghafourian, Jindrich Cinatl Jr.;
Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status.
Oncotarget 6:17605-17620(2015)

Cross-references
Encyclopedic resources Wikidata; Q54990287
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number12