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Cellosaurus UKF-NB-2rVCR10 (CVCL_9910)

[Text version]
Cell line name UKF-NB-2rVCR10
Synonyms UKF-NB-2 VCR
Accession CVCL_9910
Resource Identification Initiative To cite this cell line use: UKF-NB-2rVCR10 (RRID:CVCL_9910)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Doubling time: 27 hours (PubMed=12532417).
Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9902 (UKF-NB-2)
Category Cancer cell line
Web pages https://www.wass-michaelislab.org/rccl.php
Publications

PubMed=12532417; DOI=10.1002/ijc.10917
Kotchetkov R., Cinatl J., Blaheta R.A., Vogel J.-U., Karaskova J., Squire J.A., Hernaiz Driever P., Klingebiel T., Cinatl J. Jr.
Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: a preclinical model.
Int. J. Cancer 104:36-43(2003)

PubMed=16151587
Bedrnicek J., Vicha A., Jarosova M., Holzerova M., Cinatl J. Jr., Michaelis M., Cinatl J., Eckschlager T.
Characterization of drug-resistant neuroblastoma cell lines by comparative genomic hybridization.
Neoplasma 52:415-419(2005)

PubMed=17505515; DOI=10.1038/sj.bjc.6603777; PMCID=PMC2359931
Blaheta R.A., Michaelis M., Natsheh I., Hasenberg C., Weich E., Relja B., Jonas D., Doerr H.-W., Cinatl J. Jr.
Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium.
Br. J. Cancer 96:1699-1706(2007)

PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738
Michaelis M., Rothweiler F., Barth S., Cinatl J., van Rikxoort M., Loschmann N., Voges Y., Breitling R., von Deimling A., Rodel F., Weber K., Fehse B., Mack E., Stiewe T., Doerr H.-W., Speidel D., Cinatl J. Jr.
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.
Cell Death Dis. 2:e243.1-e243.8(2011)

PubMed=25749379; DOI=10.18632/oncotarget.2889; PMCID=PMC4627332
Michaelis M., Rothweiler F., Loschmann N., Sharifi M., Ghafourian T., Cinatl J. Jr.
Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status.
Oncotarget 6:17605-17620(2015)

Cross-references
Encyclopedic resources Wikidata; Q54990306
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number15