ID   UKF-NB-2
AC   CVCL_9902
SY   UKF-NB2
DR   Wikidata; Q54990287
RX   CelloPub=CLPUB00123;
RX   PubMed=8949988;
RX   PubMed=9201287;
RX   PubMed=9443419;
RX   PubMed=12532417;
RX   PubMed=16151587;
RX   PubMed=17505515;
RX   PubMed=22170099;
RX   PubMed=24466371;
RX   PubMed=25749379;
CC   Doubling time: 22.5-25.6 hours (PubMed=9443419); 25 hours (PubMed=12532417).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 12
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RX   CelloPub=CLPUB00123;
RA   Cinatl J., Gussetis E.S., Cinatl J. Jr., Ebener U., Mainke M.,
RA   Schwabe D., Doerr H.-W., Kornhuber B., Gerein V.;
RT   "Differentiation arrest in neuroblastoma cell culture.";
RL   J. Cancer Res. Clin. Oncol. 116 Suppl. 1:9-9(1990).
//
RX   PubMed=8949988; DOI=10.1097/00001813-199609000-00008;
RA   Cinatl J. Jr., Cinatl J., Scholz M., Hernaiz Driever P., Henrich D.,
RA   Kabickova H., Vogel J.-U., Doerr H.-W., Kornhuber B.;
RT   "Antitumor activity of sodium valproate in cultures of human
RT   neuroblastoma cells.";
RL   Anticancer Drugs 7:766-773(1996).
//
RX   PubMed=9201287;
RA   Cinatl J. Jr., Hernaiz Driever P., Cinatl J., Ruckert D.G.,
RA   Gumbel H.O., Rabenau H.F., Kornhuber B., Doerr H.-W.;
RT   "Increased efficacy of aphidicolin killing of human neuroblastoma
RT   cells in vitro by encapsulation in liposomes.";
RL   Neoplasma 44:91-95(1997).
//
RX   PubMed=9443419;
RA   Cinatl J. Jr., Cinatl J., Vogel J.-U., Kotchetkov R.,
RA   Hernaiz Driever P., Kabickova H., Kornhuber B., Schwabe D.,
RA   Doerr H.-W.;
RT   "Persistent human cytomegalovirus infection induces drug resistance
RT   and alteration of programmed cell death in human neuroblastoma
RT   cells.";
RL   Cancer Res. 58:367-372(1998).
//
RX   PubMed=12532417; DOI=10.1002/ijc.10917;
RA   Kotchetkov R., Cinatl J., Blaheta R.A., Vogel J.-U., Karaskova J.,
RA   Squire J.A., Hernaiz Driever P., Klingebiel T., Cinatl J. Jr.;
RT   "Development of resistance to vincristine and doxorubicin in
RT   neuroblastoma alters malignant properties and induces additional
RT   karyotype changes: a preclinical model.";
RL   Int. J. Cancer 104:36-43(2003).
//
RX   PubMed=16151587;
RA   Bedrnicek J., Vicha A., Jarosova M., Holzerova M., Cinatl J. Jr.,
RA   Michaelis M., Cinatl J., Eckschlager T.;
RT   "Characterization of drug-resistant neuroblastoma cell lines by
RT   comparative genomic hybridization.";
RL   Neoplasma 52:415-419(2005).
//
RX   PubMed=17505515; DOI=10.1038/sj.bjc.6603777;
RA   Blaheta R.A., Michaelis M., Natsheh I., Hasenberg C., Weich E.,
RA   Relja B., Jonas D., Doerr H.-W., Cinatl J. Jr.;
RT   "Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant
RT   neuroblastoma tumour cells to endothelium.";
RL   Br. J. Cancer 96:1699-1706(2007).
//
RX   PubMed=22170099; DOI=10.1038/cddis.2011.129;
RA   Michaelis M., Rothweiler F., Barth S., Cinatl J., van Rikxoort M.,
RA   Loschmann N., Voges Y., Breitling R., von Deimling A., Rodel F.,
RA   Weber K., Fehse B., Mack E., Stiewe T., Doerr H.-W., Speidel D.,
RA   Cinatl J. Jr.;
RT   "Adaptation of cancer cells from different entities to the MDM2
RT   inhibitor nutlin-3 results in the emergence of p53-mutated
RT   multi-drug-resistant cancer cells.";
RL   Cell Death Dis. 2:e243.1-e243.8(2011).
//
RX   PubMed=24466371; DOI=10.1593/tlo.13544;
RA   Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J.,
RA   Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A.,
RA   Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.;
RT   "Testing of SNS-032 in a panel of human neuroblastoma cell lines with
RT   acquired resistance to a broad range of drugs.";
RL   Transl. Oncol. 6:685-696(2013).
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RX   PubMed=25749379; DOI=10.18632/oncotarget.2889;
RA   Michaelis M., Rothweiler F., Loschmann N., Sharifi M., Ghafourian T.,
RA   Cinatl J. Jr.;
RT   "Enzastaurin inhibits ABCB1-mediated drug efflux independently of
RT   effects on protein kinase C signalling and the cellular p53 status.";
RL   Oncotarget 6:17605-17620(2015).
//