Cellosaurus HepaRG (CVCL_9720)
Cell line name | HepaRG | |||||||
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Synonyms | Hepa-RG | |||||||
Accession | CVCL_9720 | |||||||
Resource Identification Initiative | To cite this cell line use: HepaRG (RRID:CVCL_9720) | |||||||
Comments | Group: Patented cell line. Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-2652. Characteristics: Can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Characteristics: Cell line main applications are sugar and lipid metabolism, physiopathology; drug metabolism and toxicology and viral infection. Doubling time: 24 hours (PubMed=12432097). Omics: Deep exome analysis. Omics: Deep proteome analysis. Omics: Membrane proteome analysis. Omics: miRNA expression profiling. Omics: Protein expression by reverse-phase protein arrays. Omics: Secretome proteome analysis. Omics: Transcriptome analysis by microarray. Anecdotal: The 'RG' in the cell name stands for Rumin and Gripon, the two scientists that were influential in the establishment of this cell line. Miscellaneous: This cell line is exclusively produced and controlled by Biopredic International and owned by Inserm. BioPredic sells undifferentiated cell line (HPR101) that can be expanded, passaged, and frozen in-house to prepare a cell bank and differentiated ready-to-use cells (HPR116) that can be used immediately or in a few days after thawing, as a single-use disposable product. Derived from site: In situ; Liver; UBERON=UBERON_0002107. | |||||||
Disease | Hepatitis C infection (NCIt: C3098) Hepatocellular carcinoma (NCIt: C3099) Hepatocellular carcinoma (ORDO: Orphanet_88673) | |||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | |||||||
Hierarchy | Children:
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Sex of cell | Female | |||||||
Age at sampling | Age unspecified | |||||||
Category | Cancer cell line | |||||||
Web pages | https://en.wikipedia.org/wiki/HepaRG https://web.archive.org/web/20221228183303/http://www.heparg.com/ https://lccl.zucmanlab.com/hcc/cellLines/HepaRG http://triangleresearchlabs.net/products-hepatocytes/nospin-heparg/ https://www.thermofisher.com/order/catalog/product/HPRGC10 | |||||||
Publications | PubMed=12432097; DOI=10.1073/pnas.232137699; PMCID=PMC137772 PubMed=17241619; DOI=10.1016/j.cbi.2006.12.003 PubMed=17393521; DOI=10.1002/hep.21536 Patent=US7456018 PubMed=20228232; DOI=10.1124/dmd.109.031831; PMCID=PMC2879958 PubMed=20645056; DOI=10.1007/978-1-60761-688-7_13 PubMed=21414303; DOI=10.1016/j.bcp.2011.03.004 PubMed=22568886; DOI=10.1517/17425255.2012.685159 PubMed=22594799; DOI=10.3109/13813455.2012.683442 PubMed=22643240; DOI=10.1016/j.tiv.2012.05.008 PubMed=22857383; DOI=10.1186/1477-5956-10-47; PMCID=PMC3527237 PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665 PubMed=26160117; DOI=10.1093/toxsci/kfv136; PMCID=PMC4583060 PubMed=26694163; DOI=10.1371/journal.pone.0144924; PMCID=PMC4692263 PubMed=27027780; DOI=10.1007/s10565-016-9316-2 PubMed=27169750; DOI=10.1038/srep24709; PMCID=PMC4867683 PubMed=27780834; DOI=10.1124/dmd.116.072603 PubMed=27975304; DOI=10.1007/978-1-4939-6700-1_2 PubMed=28904299; DOI=10.2131/jts.42.641 PubMed=30795634; DOI=10.3390/cells8020192; PMCID=PMC6406872 PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001 PubMed=33441761; DOI=10.1038/s41598-020-79952-1; PMCID=PMC7806635 | |||||||
Cross-references | ||||||||
Cell line collections (Providers) | Millipore; C103485 - Discontinued | |||||||
Anatomy/cell type resources | BTO; BTO:0005736 | |||||||
Chemistry resources | ChEMBL-Cells; CHEMBL4630773
ChEMBL-Targets; CHEMBL4630781 PubChem_Cell_line; CVCL_9720 | |||||||
Encyclopedic resources | Wikidata; Q54882834 | |||||||
Experimental variables resources | EFO; EFO_0001186 | |||||||
Metabolomic databases | MetaboLights; MTBLS78 | |||||||
Polymorphism and mutation databases | Cosmic; 2162524 | |||||||
Proteomic databases | PRIDE; PXD001107
PRIDE; PXD004752 PRIDE; PXD006267 PRIDE; PXD010304 | |||||||
Entry history | ||||||||
Entry creation | 06-Jun-2012 | |||||||
Last entry update | 02-May-2024 | |||||||
Version number | 31 |