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Cellosaurus GLC-2 (CVCL_8207)

[Text version]
Cell line name GLC-2
Synonyms GLC 2; GLC2; OC-Ny; OC-NYH; NYH
Accession CVCL_8207
Resource Identification Initiative To cite this cell line use: GLC-2 (RRID:CVCL_8207)
Comments Doubling time: 37 hours (PubMed=2998591).
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Unexplicit; Ex8del14; Zygosity=Unspecified (PubMed=10408787).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0B24 (NYH/187/162)CVCL_0B25 (NYH/187/165)CVCL_0B26 (NYH/CAM)
CVCL_0B27 (NYH/CIS)CVCL_0B28 (NYH/TPT)CVCL_0B29 (NYH/VM)
Sex of cell Male
Age at sampling 41Y
Category Cancer cell line
STR profile Source(s): PubMed=24586258

Markers:
AmelogeninX,Y
CSF1PO12,13
D3S135817
D5S81812,13
D7S8209,12
D8S117912
D13S31714
D16S53912
D18S5115,18
D21S1130,32
FGA21,23
Penta D11,13
Penta E7,10
TH016,9.3
TPOX11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=2998591
Lou F.M.H. de Leij, Pieter Edsge Postmus, Charles H.C.M. Buys, Job D. Elema, Frans C.S. Ramaekers, Sibrandes Poppema, Marjoleine Brouwer, Anneke Y. van der Veen, Geert Mesander, Tjwan Hauw The;
Characterization of three new variant type cell lines derived from small cell carcinoma of the lung.
Cancer Res. 45:6024-6033(1985)

PubMed=2473086; DOI=10.1242/jcs.91.1.91
Jos L.V. Broers, Mirjam Klein Rot, Tineke Oostendorp, Gerold Bepler, Lou F.M.H. de Leij, Desmond Niall Carney, Gijsbert Peter Vooijs, Frans C.S. Ramaekers;
Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines.
J. Cell Sci. 91:91-108(1988)

PubMed=2574988; DOI=10.1038/bjc.1989.376; PMCID=PMC2247271
Peter Buhl Jensen, Lars L. Vindelov, Henrik Roed, Erland Johannes Frederik Demant, Maxwell Sehested, Torben Skovsgaard, Heine Hoi Hansen;
In vitro evaluation of the potential of aclarubicin in the treatment of small cell carcinoma of the lung (SCCL).
Br. J. Cancer 60:838-844(1989)

PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y
Jos L.V. Broers, Eddy P. Mijnheere, Mirjam Klein Rot, Gert Schaart, Alfred Sijlmans, Otto C. Boerman, Frans C.S. Ramaekers;
Novel antigens characteristic of neuroendocrine malignancies.
Cancer 67:619-633(1991)

PubMed=1320893; DOI=10.1159/000163712
Marken A.E. Verbeeck, Jack P.M. Elands, Lou F.M.H. de Leij, Charles H.C.M. Buys, Desmond Niall Carney, Gerold Bepler, Anton J.M. Roebroek, Wim J.M. van de Ven, J. Peter H. Burbach;
Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.
Pathobiology 60:136-142(1992)

PubMed=9212023; DOI=10.1016/S0360-3016(97)00245-9
Marianne Krarup, Hans Skovgaard Poulsen, Mogens Spang-Thomsen;
Cellular radiosensitivity of small-cell lung cancer cell lines.
Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997)

PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0
Lois M. Mulligan, Tineke Timmer, Stacey M. Ivanchuk, Barbara G. Campling, Leah C. Young, Pamela H. Rabbitts, Vasi Sundaresan, Robert M.W. Hofstra, Charis Eng;
Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma.
Genes Chromosomes Cancer 21:326-332(1998)

PubMed=9744504; DOI=10.1038/bjc.1998.553; PMCID=PMC2063065
Lars Damstrup, Bjorn Gunnar Rude Voldborg, Mogens Spang-Thomsen, Nils Brunner, Hans Skovgaard Poulsen;
In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.
Br. J. Cancer 78:631-640(1998)

PubMed=10408787; DOI=10.1097/00019606-199903000-00002
Vanessa M. Hayes, Wim Bleeker, Edwin Verlind, Tineke Timmer, Arend Karrenbeld, John T. Plukker, Munro Peter Marx, Robert M.W. Hofstra, Charles H.C.M. Buys;
Comprehensive TP53-denaturing gradient gel electrophoresis mutation detection assay also applicable to archival paraffin-embedded tissue.
Diagn. Mol. Pathol. 8:2-10(1999)

PubMed=10416608
Irene Wessel, Lars H. Jensen, Peter Buhl Jensen, Jacob Falck, Angela Rose, Mikael Roerth, John L. Nitiss, Maxwell Sehested;
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
Cancer Res. 59:3442-3450(1999)

PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O
Pamela M.J. McLaughlin, Wijnand Helfrich, Klaas Kok, Marcel Mulder, Soesja W. Hu, Marja G.L. Brinker, Marcel H.J. Ruiters, Lou F.M.H. de Leij, Charles H.C.M. Buys;
The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.
Int. J. Cancer 85:871-876(2000)

PubMed=12044890; DOI=10.1016/S0014-5793(02)02805-3
Irene Wessel, Lars H. Jensen, Axelle Renodon-Corniere, Tina K. Sorensen, John L. Nitiss, Peter Buhl Jensen, Maxwell Sehested;
Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.
FEBS Lett. 520:161-166(2002)

PubMed=12712436; DOI=10.1002/ijc.11106
Lasse Tengbjerg Hansen, Cecilia Lundin, Mogens Spang-Thomsen, Lone Norgard Petersen, Thomas Helleday;
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
Int. J. Cancer 105:472-479(2003)

PubMed=24586258; DOI=10.1371/journal.pone.0086910; PMCID=PMC3938400
Tamara Murmann-Konda, Carmen Carrillo-Garcia, Nadine Veit, Cornelius Courts, Alexander Glassmann, Viktor Janzen, Burkhard Madea, Markus Reinartz, Anne Harzen, Michael Nowak, Sven Perner ...Show all 13 authors... , Jochen Winter, Rainer Probstmeier; Show fewer authors
Staurosporine and extracellular matrix proteins mediate the conversion of small cell lung carcinoma cells into a neuron-like phenotype.
PLoS ONE 9:e86910.1-e86910.14(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8207
Anatomy/cell type resources BTO; BTO_0005499
Encyclopedic resources Wikidata; Q54835902
Gene expression databases GEO; GSM986182
Polymorphism and mutation databases Cosmic; 1759250
Cosmic; 2239119
Cosmic; 2648015
IARC_TP53; 11280
Progenetix; CVCL_8207
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number21