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Cellosaurus NYH/187/165 (CVCL_0B25)

[Text version]
Cell line name NYH/187/165
Accession CVCL_0B25
Resource Identification Initiative To cite this cell line use: NYH/187/165 (RRID:CVCL_0B25)
Comments Selected for resistance to: ChEBI; CHEBI_50223; (+)-dexrazoxane (Cardioxane; ICRF-187).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:11989; TOP2A; Simple; p.Tyr165Ser (c.494A>C); Zygosity=Heterozygous; Note=Responsible for resistance to bisdioxopiperazine drugs (PubMed=12044890).
  • Mutation; HGNC; HGNC:11998; TP53; Unexplicit; Ex8del14; Zygosity=Unspecified (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8207 (GLC-2)
Sex of cell Male
Age at sampling 41Y
Category Cancer cell line
Publications

PubMed=12044890; DOI=10.1016/S0014-5793(02)02805-3
Wessel I., Jensen L.H., Renodon-Corniere A., Sorensen T.K., Nitiss J.L., Jensen P.B., Sehested M.
Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.
FEBS Lett. 520:161-166(2002)

Cross-references
Encyclopedic resources Wikidata; Q54931216
Entry history
Entry creation10-Apr-2015
Last entry update10-Apr-2025
Version number10