ID   GLC-2
AC   CVCL_8207
SY   GLC 2; GLC2; OC-Ny; OC-NYH; NYH
DR   BTO; BTO:0005499
DR   cancercelllines; CVCL_8207
DR   Cosmic; 1759250
DR   Cosmic; 2239119
DR   Cosmic; 2648015
DR   GEO; GSM986182
DR   IARC_TP53; 11280
DR   Progenetix; CVCL_8207
DR   Wikidata; Q54835902
RX   PubMed=1320893;
RX   PubMed=1845952;
RX   PubMed=2473086;
RX   PubMed=2574988;
RX   PubMed=2998591;
RX   PubMed=9212023;
RX   PubMed=9559344;
RX   PubMed=9744504;
RX   PubMed=10408787;
RX   PubMed=10709110;
RX   PubMed=12712436;
RX   PubMed=24586258;
CC   Doubling time: 37 hours (PubMed=2998591).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Unexplicit; Ex8del14; Zygosity=Unspecified (PubMed=10408787).
CC   Omics: SNP array analysis.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=24586258
ST   Amelogenin: X,Y
ST   CSF1PO: 12,13
ST   D13S317: 14
ST   D16S539: 12
ST   D18S51: 15,18
ST   D21S11: 30,32
ST   D3S1358: 17
ST   D5S818: 12,13
ST   D7S820: 9,12
ST   D8S1179: 12
ST   FGA: 21,23
ST   Penta D: 11,13
ST   Penta E: 7,10
ST   TH01: 6,9.3
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   41Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 19
//
RX   PubMed=1320893; DOI=10.1159/000163712;
RA   Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M.,
RA   Carney D.N., Bepler G., Roebroek A.J.M., van de Ven W.J.M.,
RA   Burbach J.P.H.;
RT   "Expression of the vasopressin and gastrin-releasing peptide genes in
RT   small cell lung carcinoma cell lines.";
RL   Pathobiology 60:136-142(1992).
//
RX   PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y;
RA   Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A.,
RA   Boerman O.C., Ramaekers F.C.S.;
RT   "Novel antigens characteristic of neuroendocrine malignancies.";
RL   Cancer 67:619-633(1991).
//
RX   PubMed=2473086; DOI=10.1242/jcs.91.1.91;
RA   Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., de Leij L.F.M.H.,
RA   Carney D.N., Vooijs G.P., Ramaekers F.C.S.;
RT   "Spontaneous changes in intermediate filament protein expression
RT   patterns in lung cancer cell lines.";
RL   J. Cell Sci. 91:91-108(1988).
//
RX   PubMed=2574988; DOI=10.1038/bjc.1989.376;
RA   Jensen P.B., Vindelov L.L., Roed H., Demant E.J.F., Sehested M.,
RA   Skovsgaard T., Hansen H.H.;
RT   "In vitro evaluation of the potential of aclarubicin in the treatment
RT   of small cell carcinoma of the lung (SCCL).";
RL   Br. J. Cancer 60:838-844(1989).
//
RX   PubMed=2998591;
RA   de Leij L.F.M.H., Postmus P.E., Buys C.H.C.M., Elema J.D.,
RA   Ramaekers F.C.S., Poppema S., Brouwer M., van der Veen A.Y.,
RA   Mesander G., The T.H.;
RT   "Characterization of three new variant type cell lines derived from
RT   small cell carcinoma of the lung.";
RL   Cancer Res. 45:6024-6033(1985).
//
RX   PubMed=9212023; DOI=10.1016/S0360-3016(97)00245-9;
RA   Krarup M., Poulsen H.S., Spang-Thomsen M.;
RT   "Cellular radiosensitivity of small-cell lung cancer cell lines.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997).
//
RX   PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0;
RA   Mulligan L.M., Timmer T., Ivanchuk S.M., Campling B.G., Young L.C.,
RA   Rabbitts P.H., Sundaresan V., Hofstra R.M.W., Eng C.;
RT   "Investigation of the genes for RET and its ligand complex, GDNF/GFR
RT   alpha-I, in small cell lung carcinoma.";
RL   Genes Chromosomes Cancer 21:326-332(1998).
//
RX   PubMed=9744504; DOI=10.1038/bjc.1998.553;
RA   Damstrup L., Voldborg B.G.R., Spang-Thomsen M., Brunner N.,
RA   Poulsen H.S.;
RT   "In vitro invasion of small-cell lung cancer cell lines correlates
RT   with expression of epidermal growth factor receptor.";
RL   Br. J. Cancer 78:631-640(1998).
//
RX   PubMed=10408787; DOI=10.1097/00019606-199903000-00002;
RA   Hayes V.M., Bleeker W., Verlind E., Timmer T., Karrenbeld A.,
RA   Plukker J.T., Marx M.P., Hofstra R.M.W., Buys C.H.C.M.;
RT   "Comprehensive TP53-denaturing gradient gel electrophoresis mutation
RT   detection assay also applicable to archival paraffin-embedded
RT   tissue.";
RL   Diagn. Mol. Pathol. 8:2-10(1999).
//
RX   PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O;
RA   McLaughlin P.M.J., Helfrich W., Kok K., Mulder M., Hu S.W.,
RA   Brinker M.G.L., Ruiters M.H.J., de Leij L.F.M.H., Buys C.H.C.M.;
RT   "The ubiquitin-activating enzyme E1-like protein in lung cancer cell
RT   lines.";
RL   Int. J. Cancer 85:871-876(2000).
//
RX   PubMed=12712436; DOI=10.1002/ijc.11106;
RA   Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.;
RT   "The role of RAD51 in etoposide (VP16) resistance in small cell lung
RT   cancer.";
RL   Int. J. Cancer 105:472-479(2003).
//
RX   PubMed=24586258; DOI=10.1371/journal.pone.0086910;
RA   Murmann-Konda T., Carrillo-Garcia C., Veit N., Courts C., Glassmann A.,
RA   Janzen V., Madea B., Reinartz M., Harzen A., Nowak M., Perner S.,
RA   Winter J., Probstmeier R.;
RT   "Staurosporine and extracellular matrix proteins mediate the
RT   conversion of small cell lung carcinoma cells into a neuron-like
RT   phenotype.";
RL   PLoS ONE 9:E86910-E86910(2014).
//