| Cell line name |
NYH/187/162 |
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| Synonyms |
NYH/187; NYH/ICRF-187-1 |
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| Accession |
CVCL_0B24 |
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| Resource Identification Initiative |
To cite this cell line use: NYH/187/162 (RRID:CVCL_0B24) |
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| Comments |
Selected for resistance to: ChEBI; CHEBI_50223; (+)-dexrazoxane (Cardioxane; ICRF-187).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Mutation; HGNC; HGNC:11989; TOP2A; Simple; p.Arg162Gln (c.485G>A); Zygosity=Homozygous; Note=Responsible for resistance to bisdioxopiperazine drugs (PubMed=10416608).
- Mutation; HGNC; HGNC:11998; TP53; Unexplicit; Ex8del14; Zygosity=Unspecified (from parent cell line).
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| Disease |
Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_8207 (GLC-2) |
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| Sex of cell |
Male |
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| Age at sampling |
41Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=10416608
Irene Wessel, Lars H. Jensen, Peter Buhl Jensen, Jacob Falck, Angela Rose, Mikael Roerth, John L. Nitiss, Maxwell Sehested;
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
Cancer Res. 59:3442-3450(1999) PubMed=12044890; DOI=10.1016/S0014-5793(02)02805-3
Irene Wessel, Lars H. Jensen, Axelle Renodon-Corniere, Tina K. Sorensen, John L. Nitiss, Peter Buhl Jensen, Maxwell Sehested;
Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.
FEBS Lett. 520:161-166(2002) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q54931215
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| Entry history |
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| Entry creation | 10-Apr-2015 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 10 |
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