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Cellosaurus OCM-1 (CVCL_6934)

[Text version]
Cell line name OCM-1
Synonyms OCM1; Ocm1; Ocular Choroidal Melanoma-1
Accession CVCL_6934
Resource Identification Initiative To cite this cell line use: OCM-1 (RRID:CVCL_6934)
Comments Problematic cell line: Contaminated. Shown to be a M14 derivative (PubMed=28940260). Originally thought to originate from a female patient with uveal melanoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00502.
Population: Caucasian.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=22236444).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1395 (M14)
CVCL_6935 (OCM-1A)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): PubMed=18689700


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

Kan-Mitchell J., Mitchell M.S., Rao N., Liggett P.E.
Characterization of uveal melanoma cell lines that grow as xenografts in rabbit eyes.
Invest. Ophthalmol. Vis. Sci. 30:829-834(1989)

PubMed=8621261; DOI=10.1002/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F
Luyten G.P.M., Naus N.C., Mooy C.M., Hagemeijer A., Kan-Mitchell J., van Drunen E., Vuzevski V., de Jong P.T.V.M., Luider T.M.
Establishment and characterization of primary and metastatic uveal melanoma cell lines.
Int. J. Cancer 66:380-387(1996)

PubMed=9154388; DOI=10.1076/ceyr.16.5.487.7047
Diebold Y., Blanco G., Saornil-Alvarez M.A., Fernandez N., Lazaro M.C.
Morphologic and immunocytochemical characterization of four human uveal cell lines (melanoma- and melanocytes-derived).
Curr. Eye Res. 16:487-495(1997)

PubMed=15714118; DOI=10.1097/00008390-200502000-00006
Lopez-Velasco R., Morilla-Grasa A., Saornil-Alvarez M.A., Ordonez J.L., Blanco G., Rabano G., Fernandez N., Almaraz A.
Efficacy of five human melanocytic cell lines in experimental rabbit choroidal melanoma.
Melanoma Res. 15:29-37(2005)

PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016
White J.S., Becker R.L., McLean I.W., Director-Myska A.E., Nath J.
Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.
Cancer Genet. Cytogenet. 168:11-21(2006)

PubMed=17487557; DOI=10.1007/s10585-007-9072-z
Marshall J.-C., Nantel A., Blanco P., Ash J., Cruess S.R., Burnier M.N. Jr.
Transcriptional profiling of human uveal melanoma from cell lines to intraocular tumors to metastasis.
Clin. Exp. Metastasis 24:353-362(2007)

PubMed=18689700; DOI=10.1167/iovs.08-2324
Folberg R., Kadkol S.S., Frenkel S., Valyi-Nagy K., Jager M.J., Pe'er J., Maniotis A.J.
Authenticating cell lines in ophthalmic research laboratories.
Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x
Griewank K.G., Yu X.-X., Khalili J.S., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011
Amaro A., Mirisola V., Angelini G., Musso A., Tosetti F.I., Esposito A.I., Perri P., Lanza F.B., Nasciuti F., Mosci C., Puzone R., Salvi S., Truini M., Poggi A., Pfeffer U.
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.
Eur. J. Cancer 49:3353-3365(2013)

PubMed=28940260; DOI=10.1002/ijc.31067
Korch C.T., Hall E.M., Dirks W.G., Ewing M., Faries M., Varella-Garcia M., Robinson S., Storts D.R., Turner J.A., Wang Y., Burnett E.C., Healy L.E., Kniss D.A., Neve R.M., Nims R.W., Reid Y.A., Robinson W.A., Capes-Davis A.
Authentication of M14 melanoma cell line proves misidentification of MDA-MB-435 breast cancer cell line.
Int. J. Cancer 142:561-572(2017)

Cell line databases/resources cancercelllines; CVCL_6934
Anatomy/cell type resources BTO; BTO:0002736
Encyclopedic resources Wikidata; Q54931805
Gene expression databases GEO; GSM276733
Polymorphism and mutation databases Cosmic; 848327
Cosmic; 899892
Cosmic; 916139
Cosmic; 986617
Cosmic; 1320368
Cosmic; 1628408
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number29