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Cellosaurus OCM-1 (CVCL_6934)

[Text version]
Cell line name OCM-1
Synonyms OCM1; Ocm1; Ocular Choroidal Melanoma-1
Accession CVCL_6934
Resource Identification Initiative To cite this cell line use: OCM-1 (RRID:CVCL_6934)
Comments Problematic cell line: Contaminated. Shown to be a M14 derivative (PubMed=28940260). Originally thought to originate from a female patient with uveal melanoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00502.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=22236444).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Derived from metastatic site: Right buttock; hypodermis.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1395 (M14)
CVCL_6935 (OCM-1A)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): PubMed=18689700


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

Kan-Mitchell J., Mitchell M.S., Rao N., Liggett P.E.
Characterization of uveal melanoma cell lines that grow as xenografts in rabbit eyes.
Invest. Ophthalmol. Vis. Sci. 30:829-834(1989)

PubMed=8621261; DOI=10.1002/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F
Luyten G.P.M., Naus N.C., Mooy C.M., Hagemeijer A., Kan-Mitchell J., van Drunen E., Vuzevski V., de Jong P.T.V.M., Luider T.M.
Establishment and characterization of primary and metastatic uveal melanoma cell lines.
Int. J. Cancer 66:380-387(1996)

PubMed=9154388; DOI=10.1076/ceyr.16.5.487.7047
Diebold Y., Blanco G., Saornil M.A., Fernandez N., Lazaro M.C.
Morphologic and immunocytochemical characterization of four human uveal cell lines (melanoma- and melanocytes-derived).
Curr. Eye Res. 16:487-495(1997)

PubMed=15714118; DOI=10.1097/00008390-200502000-00006
Lopez-Velasco R., Morilla-Grasa A., Saornil-Alvarez M.A., Ordonez J.L., Blanco G., Rabano G., Fernandez N., Almaraz A.
Efficacy of five human melanocytic cell lines in experimental rabbit choroidal melanoma.
Melanoma Res. 15:29-37(2005)

PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016
White J.S., Becker R.L., McLean I.W., Director-Myska A.E., Nath J.
Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.
Cancer Genet. Cytogenet. 168:11-21(2006)

PubMed=17487557; DOI=10.1007/s10585-007-9072-z
Marshall J.-C., Nantel A., Blanco P., Ash J., Cruess S.R., Burnier M.N. Jr.
Transcriptional profiling of human uveal melanoma from cell lines to intraocular tumors to metastasis.
Clin. Exp. Metastasis 24:353-362(2007)

PubMed=18689700; DOI=10.1167/iovs.08-2324
Folberg R., Kadkol S.S., Frenkel S., Valyi-Nagy K., Jager M.J., Pe'er J., Maniotis A.J.
Authenticating cell lines in ophthalmic research laboratories.
Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x
Griewank K.G., Yu X., Khalili J., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=28940260; DOI=10.1002/ijc.31067
Korch C.T., Hall E.M., Dirks W.G., Ewing M., Faries M., Varella-Garcia M., Robinson S., Storts D.R., Turner J.A., Wang Y., Burnett E.C., Healy L.E., Kniss D.A., Neve R.M., Nims R.W., Reid Y.A., Robinson W.A., Capes-Davis A.
Authentication of M14 melanoma cell line proves misidentification of MDA-MB-435 breast cancer cell line.
Int. J. Cancer 142:561-572(2017)

Anatomy/cell type resources BTO; BTO:0002736
Encyclopedic resources Wikidata; Q54931805
Gene expression databases GEO; GSM276733
Polymorphism and mutation databases Cosmic; 848327
Cosmic; 899892
Cosmic; 916139
Cosmic; 986617
Cosmic; 1320368
Cosmic; 1628408
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number26