ID OCM-1 AC CVCL_6934 SY OCM1; Ocm1; Ocular Choroidal Melanoma-1 DR BTO; BTO_0002736 DR cancercelllines; CVCL_6934 DR Cosmic; 848327 DR Cosmic; 899892 DR Cosmic; 916139 DR Cosmic; 986617 DR Cosmic; 1320368 DR Cosmic; 1628408 DR GEO; GSM276733 DR Wikidata; Q54931805 RX PubMed=2722439; RX PubMed=8621261; RX PubMed=9154388; RX PubMed=15714118; RX PubMed=16772116; RX PubMed=17487557; RX PubMed=18689700; RX PubMed=22236444; RX PubMed=23849826; RX PubMed=28940260; WW Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx CC Problematic cell line: Contaminated. Shown to be a M14 derivative (PubMed=28940260). Originally thought to originate from a female patient with uveal melanoma. CC Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00502. CC Population: Caucasian. CC Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=22236444). CC Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line). CC Omics: Transcriptomics; Microarray. CC Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072. ST Source(s): PubMed=18689700 ST Amelogenin: X ST CSF1PO: 11 ST D13S317: 12 ST D16S539: 9 ST D18S51: 13,18 ST D21S11: 30 ST D3S1358: 14,16 ST D5S818: 11,12 ST D7S820: 8,10 ST D8S1179: 13 ST FGA: 21 ST TH01: 6,7 ST TPOX: 8,11 ST vWA: 18 DI NCIt; C3802; Amelanotic melanoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_1395 ! M14 SX Male AG 33Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 31 CH CVCL_6935 ! OCM-1A // RX PubMed=28940260; DOI=10.1002/ijc.31067; PMCID=PMC5762610; RA Korch, Christopher T. RA Hall, Erin M. RA Dirks, Wilhelm Gerhard RA Ewing, Margaret RA Faries, Mark RA Varella-Garcia, Marileila RA Robinson, Steven RA Storts, Douglas R. RA Turner, Jacqueline A. RA Wang, Ying RA Burnett, Edward C. RA Healy, Lyn E. RA Kniss, Douglas A. RA Neve, Richard M. RA Nims, Raymond Whiting RA Reid, Yvonne A. RA Robinson, William A. RA Capes-Davis, Amanda RT "Authentication of M14 melanoma cell line proves misidentification of RT MDA-MB-435 breast cancer cell line."; RL Int. J. Cancer 142:561-572(2018). // RX PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011; RA Amaro, Adriana RA Mirisola, Valentina RA Angelini, Giovanna RA Musso, Alessandra RA Tosetti, Francesca Isabella RA Esposito, Alessia Isabella RA Perri, Patrizia RA Lanza, Francesco Baldo RA Nasciuti, Francesca RA Mosci, Carlo RA Puzone, Roberto RA Salvi, Sandra RA Truini, Mauro RA Poggi, Alessandro RA Pfeffer, Ulrich RT "Evidence of epidermal growth factor receptor expression in uveal RT melanoma: inhibition of epidermal growth factor-mediated signalling RT by gefitinib and cetuximab triggered antibody-dependent cellular RT cytotoxicity."; RL Eur. J. Cancer 49:3353-3365(2013). // RX PubMed=15714118; DOI=10.1097/00008390-200502000-00006; RA Lopez-Velasco, Rosario RA Morilla-Grasa, Antonio RA Saornil-Alvarez, Maria Antonia RA Ordonez, Jose L. RA Blanco, Gonzalo RA Rabano, Guillermo RA Fernandez, Nieves RA Almaraz, Ana RT "Efficacy of five human melanocytic cell lines in experimental rabbit RT choroidal melanoma."; RL Melanoma Res. 15:29-37(2005). // RX PubMed=8621261; DOI=10.1002/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F; RA Luyten, Gregorius Petrus Maria RA Naus, Nicole C. RA Mooy, Cornelia M. RA Hagemeijer, Anne RA Kan-Mitchell, June RA van Drunen, Ellen RA Vuzevski, Vojislav RA de Jong, Paulus T.V.M. RA Luider, Theo M. RT "Establishment and characterization of primary and metastatic uveal RT melanoma cell lines."; RL Int. J. Cancer 66:380-387(1996). // RX PubMed=17487557; DOI=10.1007/s10585-007-9072-z; RA Marshall, Jean-Claude RA Nantel, Andre RA Blanco, Paula RA Ash, Josee RA Cruess, Stephanie R. RA Burnier, Miguel Noel Jr. RT "Transcriptional profiling of human uveal melanoma from cell lines to RT intraocular tumors to metastasis."; RL Clin. Exp. Metastasis 24:353-362(2007). // RX PubMed=9154388; DOI=10.1076/ceyr.16.5.487.7047; RA Diebold, Yolanda RA Blanco, Gonzalo RA Saornil-Alvarez, Maria Antonia RA Fernandez, Nieves RA Lazaro, M. Carmen RT "Morphologic and immunocytochemical characterization of four human RT uveal cell lines (melanoma- and melanocytes-derived)."; RL Curr. Eye Res. 16:487-495(1997). // RX PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394; RA Griewank, Klaus Georg RA Yu, Xiao-Xing RA Khalili, Jahan S. RA Sozen, Mustafa Mert RA Stemke-Hale, Katherine RA Bernatchez, Chantale RA Wardell, Seth RA Bastian, Boris C. RA Woodman, Scott E. RT "Genetic and molecular characterization of uveal melanoma cell RT lines."; RL Pigment Cell Melanoma Res. 25:182-187(2012). // RX PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016; RA White, Jason S. RA Becker, Robert L. RA McLean, Ian W. RA Director-Myska, Alison E. RA Nath, Joginder RT "Molecular cytogenetic evaluation of 10 uveal melanoma cell lines."; RL Cancer Genet. Cytogenet. 168:11-21(2006). // RX PubMed=2722439; RA Kan-Mitchell, June RA Mitchell, Malcolm S. RA Rao, Narsing RA Liggett, Peter E. RT "Characterization of uveal melanoma cell lines that grow as xenografts RT in rabbit eyes."; RL Invest. Ophthalmol. Vis. Sci. 30:829-834(1989). // RX PubMed=18689700; DOI=10.1167/iovs.08-2324; PMCID=PMC2576485; RA Folberg, Robert RA Kadkol, ShriHari S. RA Frenkel, Shahar RA Valyi-Nagy, Klara RA Jager, Martine Johanna RA Pe'er, Jacob RA Maniotis, Andrew J. RT "Authenticating cell lines in ophthalmic research laboratories."; RL Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008). //