ID   OCM-1
AC   CVCL_6934
SY   OCM1; Ocm1; Ocular Choroidal Melanoma-1
DR   BTO; BTO_0002736
DR   cancercelllines; CVCL_6934
DR   Cosmic; 848327
DR   Cosmic; 899892
DR   Cosmic; 916139
DR   Cosmic; 986617
DR   Cosmic; 1320368
DR   Cosmic; 1628408
DR   GEO; GSM276733
DR   Wikidata; Q54931805
RX   PubMed=2722439;
RX   PubMed=8621261;
RX   PubMed=9154388;
RX   PubMed=15714118;
RX   PubMed=16772116;
RX   PubMed=17487557;
RX   PubMed=18689700;
RX   PubMed=22236444;
RX   PubMed=23849826;
RX   PubMed=28940260;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a M14 derivative (PubMed=28940260). Originally thought to originate from a female patient with uveal melanoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00502.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=22236444).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
ST   Source(s): PubMed=18689700
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 9
ST   D18S51: 13,18
ST   D21S11: 30
ST   D3S1358: 14,16
ST   D5S818: 11,12
ST   D7S820: 8,10
ST   D8S1179: 13
ST   FGA: 21
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 18
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1395 ! M14
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
//
RX   PubMed=2722439;
RA   Kan-Mitchell, June
RA   Mitchell, Malcolm S.
RA   Rao, Narsing
RA   Liggett, Peter E.
RT   "Characterization of uveal melanoma cell lines that grow as xenografts
RT   in rabbit eyes.";
RL   Invest. Ophthalmol. Vis. Sci. 30:829-834(1989).
//
RX   PubMed=8621261; DOI=10.1002/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F;
RA   Luyten, Gregorius P.M.
RA   Naus, Nicole C.
RA   Mooy, Cornelia M.
RA   Hagemeijer, Anne
RA   Kan-Mitchell, June
RA   van Drunen, Ellen
RA   Vuzevski, Vojislav
RA   de Jong, Paulus T.V.M.
RA   Luider, Theo M.
RT   "Establishment and characterization of primary and metastatic uveal
RT   melanoma cell lines.";
RL   Int. J. Cancer 66:380-387(1996).
//
RX   PubMed=9154388; DOI=10.1076/ceyr.16.5.487.7047;
RA   Diebold, Yolanda
RA   Blanco, Gonzalo
RA   Saornil-Alvarez, Maria Antonia
RA   Fernandez, Nieves
RA   Lazaro, M. Carmen
RT   "Morphologic and immunocytochemical characterization of four human
RT   uveal cell lines (melanoma- and melanocytes-derived).";
RL   Curr. Eye Res. 16:487-495(1997).
//
RX   PubMed=15714118; DOI=10.1097/00008390-200502000-00006;
RA   Lopez-Velasco, Rosario
RA   Morilla-Grasa, Antonio
RA   Saornil-Alvarez, Maria Antonia
RA   Ordonez, Jose L.
RA   Blanco, Gonzalo
RA   Rabano, Guillermo
RA   Fernandez, Nieves
RA   Almaraz, Ana
RT   "Efficacy of five human melanocytic cell lines in experimental rabbit
RT   choroidal melanoma.";
RL   Melanoma Res. 15:29-37(2005).
//
RX   PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016;
RA   White, Jason S.
RA   Becker, Robert L.
RA   McLean, Ian W.
RA   Director-Myska, Alison E.
RA   Nath, Joginder
RT   "Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.";
RL   Cancer Genet. Cytogenet. 168:11-21(2006).
//
RX   PubMed=17487557; DOI=10.1007/s10585-007-9072-z;
RA   Marshall, Jean-Claude
RA   Nantel, Andre
RA   Blanco, Paula
RA   Ash, Josee
RA   Cruess, Stephanie R.
RA   Burnier, Miguel Noel Jr.
RT   "Transcriptional profiling of human uveal melanoma from cell lines to
RT   intraocular tumors to metastasis.";
RL   Clin. Exp. Metastasis 24:353-362(2007).
//
RX   PubMed=18689700; DOI=10.1167/iovs.08-2324; PMCID=PMC2576485;
RA   Folberg, Robert
RA   Kadkol, ShriHari S.
RA   Frenkel, Shahar
RA   Valyi-Nagy, Klara
RA   Jager, Martine Johanna
RA   Pe'er, Jacob
RA   Maniotis, Andrew J.
RT   "Authenticating cell lines in ophthalmic research laboratories.";
RL   Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008).
//
RX   PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394;
RA   Griewank, Klaus Georg
RA   Yu, Xiao-Xing
RA   Khalili, Jahan S.
RA   Sozen, Mustafa Mert
RA   Stemke-Hale, Katherine
RA   Bernatchez, Chantale
RA   Wardell, Seth
RA   Bastian, Boris C.
RA   Woodman, Scott E.
RT   "Genetic and molecular characterization of uveal melanoma cell
RT   lines.";
RL   Pigment Cell Melanoma Res. 25:182-187(2012).
//
RX   PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011;
RA   Amaro, Adriana
RA   Mirisola, Valentina
RA   Angelini, Giovanna
RA   Musso, Alessandra
RA   Tosetti, Francesca Isabella
RA   Esposito, Alessia Isabella
RA   Perri, Patrizia
RA   Lanza, Francesco Baldo
RA   Nasciuti, Francesca
RA   Mosci, Carlo
RA   Puzone, Roberto
RA   Salvi, Sandra
RA   Truini, Mauro
RA   Poggi, Alessandro
RA   Pfeffer, Ulrich
RT   "Evidence of epidermal growth factor receptor expression in uveal
RT   melanoma: inhibition of epidermal growth factor-mediated signalling
RT   by gefitinib and cetuximab triggered antibody-dependent cellular
RT   cytotoxicity.";
RL   Eur. J. Cancer 49:3353-3365(2013).
//
RX   PubMed=28940260; DOI=10.1002/ijc.31067; PMCID=PMC5762610;
RA   Korch, Christopher T.
RA   Hall, Erin M.
RA   Dirks, Wilhelm Gerhard
RA   Ewing, Margaret
RA   Faries, Mark
RA   Varella-Garcia, Marileila
RA   Robinson, Steven
RA   Storts, Douglas R.
RA   Turner, Jacqueline A.
RA   Wang, Ying
RA   Burnett, Edward C.
RA   Healy, Lyn E.
RA   Kniss, Douglas A.
RA   Neve, Richard M.
RA   Nims, Raymond Whiting
RA   Reid, Yvonne A.
RA   Robinson, William A.
RA   Capes-Davis, Amanda
RT   "Authentication of M14 melanoma cell line proves misidentification of
RT   MDA-MB-435 breast cancer cell line.";
RL   Int. J. Cancer 142:561-572(2018).
//