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Cellosaurus OCM-1A (CVCL_6935)

[Text version]
Cell line name OCM-1A
Synonyms OCM1A; OCM1a
Accession CVCL_6935
Resource Identification Initiative To cite this cell line use: OCM-1A (RRID:CVCL_6935)
Comments Problematic cell line: Contaminated. Parent cell line (OCM-1) has been shown to be a M14 derivative.
Population: Caucasian.
Miscellaneous: Formerly the CCRID database had an entry describing this cell line (3111C0001CCC000234). It was one of the sources for the STR profile of this entry.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6934 (OCM-1)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): CCRID

Markers:
AmelogeninX
CSF1PO11
D2S133819
D3S135814,16
D5S81811,12
D7S8208,10
D8S117913
D13S31712
D16S5399
D18S5113,18
D19S43314,15
D21S1130
FGA21
TH016,7
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=15299072; DOI=10.1158/1535-7163.895.3.8
Jian-Zhong Qin, Lawrence Stennett, Patricia Bacon, Barbara Bodner, Mary J.C. Hendrix, Richard E.B. Seftor, Elisabeth A. Seftor, Naira V. Margaryan, Pamela M. Pollock, Amy Curtis, Jeffrey M. Trent ...Show all 14 authors... , Frank Bennett, Lucio Miele, Brian J. Nickoloff; Show fewer authors
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.
Mol. Cancer Ther. 3:895-902(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6935
Encyclopedic resources Wikidata; Q54931806
Gene expression databases GEO; GSM1082693
Polymorphism and mutation databases Cosmic; 1247863
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number22