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Cellosaurus CNE-2 (CVCL_6889)

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Cell line name CNE-2
Synonyms CNE2
Accession CVCL_6889
Resource Identification Initiative To cite this cell line use: CNE-2 (RRID:CVCL_6889)
Comments Problematic cell line: Contaminated. On the basis of the STR profile (PubMed=18196576) it is identical to CNE-1 and seems to be a hybrid of HeLa and of cell line of unknown origin. Originally thought to originate from a 68 year old male patient with a nasopharyngeal carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00474.
Omics: Transcriptomics; RNAseq.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_6890 (CNE-2Z)CVCL_C9B8 (CNE2-IR)CVCL_B0U9 (S18)
CVCL_B0UB (S26)
Category Hybrid cell line
STR profile Source(s): PubMed=18196576

Markers:
AmelogeninX
CSF1PO10,11
D2S133817,23
D3S135815,18
D5S81811,12
D7S82010,12
D8S117912,17
D13S31710,12,13.3
D16S5399,10
D18S5113,16
D19S43313
D21S1127,30
FGA18,21
TH016,7,9
TPOX8,9,12
vWA14,16

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

CLPUB00143
Si-Zhong Zhang, Xiu-Kung Gao, Yi Zeng;
Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma.
Yi Chuan Xue Bao 10:498-503(1983)

PubMed=6852976; DOI=10.1002/ijc.2910310509
Si-Zhong Zhang, Xiu-Kung Gao, Yi Zeng;
Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma.
Int. J. Cancer 31:587-590(1983)

PubMed=17062557; DOI=10.1158/0008-5472.CAN-06-2977
Chao-Nan Qian, Bree Berghuis, Galia Tsarfaty, MaryBeth Bruch, Eric Jon Kort, Jon Ditlev, Ilan Tsarfaty, Eric Hudson, David G. Jackson, David Petillo, Jin-Dong Chen ...Show all 13 authors... , James H. Resau, Bin Tean Teh; Show fewer authors
Preparing the 'soil': the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells.
Cancer Res. 66:10365-10376(2006)

PubMed=18196576; DOI=10.1002/ijc.23374
Sylvia Yat-Yee Chan, Kwong-Wai Choy, George Sai-Wah Tsao, Qian Tao, Tao Tang, Grace Tin-Yun Chung, Kwok-Wai Lo;
Authentication of nasopharyngeal carcinoma tumor lines.
Int. J. Cancer 122:2169-2171(2008)

PubMed=20406978; DOI=10.1158/0008-5472.CAN-09-4099
Xue-Ping Feng, Hong Yi, Mao-Yu Li, Xin-Hui Li, Bin Yi, Peng-Fei Zhang, Cui Li, Fang Peng, Can-E Tang, Jian-Ling Li, Zhu-Chu Chen, Zhi-Qiang Xiao;
Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics.
Cancer Res. 70:3450-3462(2010)

PubMed=24991015; DOI=10.1128/JVI.01457-14; PMCID=PMC4178894
Michael J. Strong, Melody Baddoo, Asuka Nanbo, Miao Xu, Adriane Puetter, Zhen Lin;
Comprehensive high-throughput RNA sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes.
J. Virol. 88:10696-10704(2014)

PubMed=25028967; DOI=10.1371/journal.pone.0100843; PMCID=PMC4100732
Ying-Ying Liang, Ming-Yuan Chen, Yi-Jun Hua, Shi Chen, Li-Sheng Zheng, Xue Cao, Li-Xia Peng, Ping Xie, Bi-Jun Huang, Rui Sun, Lin Wang ...Show all 14 authors... , Yan-Qun Xiang, Xiang Guo, Chao-Nan Qian; Show fewer authors
Downregulation of Ras association domain family member 6 (RASSF6) underlies the treatment resistance of highly metastatic nasopharyngeal carcinoma cells.
PLoS ONE 9:e100843.1-e100843.9(2014)

CLPUB00484
Zhi-Hong Xu, Wen-Wen Sun, Jun-Biao Hang, Bei-Li Gao, Jia-An Hu;
RNA-seq identified a novel functional MET fusion in head and neck cancer 5-8F cell line.
Int. J. Clin. Exp. Pathol. 9:8308-8317(2016)

Cross-references
Cell line collections (Providers) CCTCC; GDC0155
Cell line databases/resources cancercelllines; CVCL_6889
Anatomy/cell type resources BTO; BTO_0005250
Biological sample resources BioSample; SAMN06481109
Chemistry resources ChEMBL-Cells; CHEMBL4295476
ChEMBL-Targets; CHEMBL4296409
PubChem_Cell_line; CVCL_6889
Encyclopedic resources Wikidata; Q54813874
Gene expression databases GEO; GSM375846
Polymorphism and mutation databases Cosmic; 755505
Cosmic; 923774
Cosmic; 944910
Cosmic; 1017619
Cosmic; 1300999
Cosmic; 1322947
Cosmic; 2366880
Progenetix; CVCL_6889
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27