Cellosaurus logo
expasy logo

Cellosaurus CNE-2 (CVCL_6889)

[Text version]
Cell line name CNE-2
Synonyms CNE2
Accession CVCL_6889
Resource Identification Initiative To cite this cell line use: CNE-2 (RRID:CVCL_6889)
Comments Problematic cell line: Contaminated. On the basis of the STR profile (PubMed=18196576) it is identical to CNE-1 and seems to be a hybrid of HeLa and of cell line of unknown origin. Originally thought to originate from a 68 year old male patient with a nasopharyngeal carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00474.
Omics: Transcriptome analysis by RNAseq.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
CVCL_6890 (CNE-2Z)CVCL_C9B8 (CNE2-IR)CVCL_B0U9 (S18)
Category Hybrid cell line
STR profile Source(s): PubMed=18196576


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

Zhang S.-H., Gao X.-C., Zeng Y.
Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma.
Yi Chuan Xue Bao 10:498-503(1983)

PubMed=6852976; DOI=10.1002/ijc.2910310509
Zhang S.-H., Gao X.-K., Zeng Y.
Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma.
Int. J. Cancer 31:587-590(1983)

PubMed=17062557; DOI=10.1158/0008-5472.CAN-06-2977
Qian C.-N., Berghuis B., Tsarfaty G., Bruch M., Kort E.J., Ditlev J., Tsarfaty I., Hudson E., Jackson D.G., Petillo D., Chen J.-D., Resau J.H., Teh B.T.
Preparing the 'soil': the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells.
Cancer Res. 66:10365-10376(2006)

PubMed=18196576; DOI=10.1002/ijc.23374
Chan S.Y.-Y., Choy K.-W., Tsao S.-W., Tao Q., Tang T., Chung G.T.-Y., Lo K.-W.
Authentication of nasopharyngeal carcinoma tumor lines.
Int. J. Cancer 122:2169-2171(2008)

PubMed=20406978; DOI=10.1158/0008-5472.CAN-09-4099
Feng X.-P., Yi H., Li M.-Y., Li X.-H., Yi B., Zhang P.-F., Li C., Peng F., Tang C.-E., Li J.-L., Chen Z.-C., Xiao Z.-Q.
Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics.
Cancer Res. 70:3450-3462(2010)

PubMed=24991015; DOI=10.1128/JVI.01457-14
Strong M.J., Baddoo M., Nanbo A., Xu M., Puetter A., Lin Z.
Comprehensive RNA-seq analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes.
J. Virol. 88:10696-10704(2014)

PubMed=25028967; DOI=10.1371/journal.pone.0100843
Liang Y.-Y., Chen M.-Y., Hua Y.-J., Chen S., Zheng L.-S., Cao X., Peng L.-X., Xie P., Huang B.-J., Sun R., Wang L., Xiang Y.-Q., Guo X., Qian C.-N.
Downregulation of Ras association domain family member 6 (RASSF6) underlies the treatment resistance of highly metastatic nasopharyngeal carcinoma cells.
PLoS ONE 9:E100843-E100843(2014)

Xu Z.-H., Sun W.-W., Hang J.-B., Gao B.-L., Hu J.-A.
RNA-seq identified a novel functional MET fusion in head and neck cancer 5-8F cell line.
Int. J. Clin. Exp. Pathol. 9:8308-8317(2016)

Cell line collections (Providers) CCTCC; GDC0155
Cell line databases/resources cancercelllines; CVCL_6889
Anatomy/cell type resources BTO; BTO:0005250
Biological sample resources BioSample; SAMN06481109
Chemistry resources ChEMBL-Cells; CHEMBL4295476
ChEMBL-Targets; CHEMBL4296409
PubChem_Cell_line; CVCL_6889
Encyclopedic resources Wikidata; Q54813874
Gene expression databases GEO; GSM375846
Polymorphism and mutation databases Cosmic; 755505
Cosmic; 923774
Cosmic; 944910
Cosmic; 1017619
Cosmic; 1300999
Cosmic; 1322947
Cosmic; 2366880
Progenetix; CVCL_6889
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number25