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Cellosaurus publication CLPUB00143

Publication number CLPUB00143
Authors Zhang S.-H., Gao X.-K., Zeng Y.
Title Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma.
Citation Yi Chuan Xue Bao 10:498-503(1983)
Abstract Nasopharyngeal carcinoma, an epithelial cancer of high incidence in South China and some African areas, is of great interest for its close association with EB virus and for the genetic predisposition to it in some ethnic populations. Recently an epithelial cell line CNE-2 has been established from a poorly differentiated nasopharyngeal carcinoma which represents the first of the kind. Cytogenetic analysis of the CNE-2 line was carried out by chromosome banding technique. It was found that the chromosome number of the CNE-2 cells varied from 87 to 107 and the modal number was 104-103. All cells contained a series of structurally abnormal chromosomes and most of them were either consistent or frequently found. Among these chromosomes there were two giant markers which, by banding pattern analysis, proved to be different from the so-called giant A marker previously found in many lymphoblastoid cell lines of NPC. Comparison between CNE-2 and CNE, another epithelial cell line which was established from well differentiated NPC indicated that while they were quite different in many cytogenetic respects they had three chromosome markers in common, namely, an iso 8q at (?;3q) and a small acrocentric one. With finding of these and the giant markers mentioned above the problem whether there exists a chromosome marker specific for NPC was discussed.
Cell lines CVCL_6889; CNE-2