ID   CNE-2
AC   CVCL_6889
DR   BTO; BTO:0005250
DR   BioSample; SAMN06481109
DR   cancercelllines; CVCL_6889
DR   ChEMBL-Cells; CHEMBL4295476
DR   ChEMBL-Targets; CHEMBL4296409
DR   Cosmic; 755505
DR   Cosmic; 923774
DR   Cosmic; 944910
DR   Cosmic; 1017619
DR   Cosmic; 1300999
DR   Cosmic; 1322947
DR   Cosmic; 2366880
DR   GEO; GSM375846
DR   Progenetix; CVCL_6889
DR   PubChem_Cell_line; CVCL_6889
DR   Wikidata; Q54813874
RX   CelloPub=CLPUB00143;
RX   CelloPub=CLPUB00484;
RX   PubMed=6852976;
RX   PubMed=17062557;
RX   PubMed=18196576;
RX   PubMed=20406978;
RX   PubMed=24991015;
RX   PubMed=25028967;
CC   Problematic cell line: Contaminated. On the basis of the STR profile (PubMed=18196576) it is identical to CNE-1 and seems to be a hybrid of HeLa and of cell line of unknown origin. Originally thought to originate from a 68 year old male patient with a nasopharyngeal carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00474.
CC   Omics: Transcriptome analysis by RNAseq.
ST   Source(s): PubMed=18196576
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 10,12,13.3
ST   D16S539: 9,10
ST   D18S51: 13,16
ST   D19S433: 13
ST   D21S11: 27,30
ST   D2S1338: 17,23
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   D8S1179: 12,17
ST   FGA: 18,21
ST   TH01: 6,7,9
ST   TPOX: 8,9,12
ST   vWA: 14,16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
CA   Hybrid cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
RX   CelloPub=CLPUB00143;
RA   Zhang S.-H., Gao X.-C., Zeng Y.;
RT   "Cytogenetic studies on an epithelial cell line derived from poorly
RT   differentiated nasopharyngeal carcinoma.";
RL   Yi Chuan Xue Bao 10:498-503(1983).
RX   CelloPub=CLPUB00484;
RA   Xu Z.-H., Sun W.-W., Hang J.-B., Gao B.-L., Hu J.-A.;
RT   "RNA-seq identified a novel functional MET fusion in head and neck
RT   cancer 5-8F cell line.";
RL   Int. J. Clin. Exp. Pathol. 9:8308-8317(2016).
RX   PubMed=6852976; DOI=10.1002/ijc.2910310509;
RA   Zhang S.-H., Gao X.-K., Zeng Y.;
RT   "Cytogenetic studies on an epithelial cell line derived from poorly
RT   differentiated nasopharyngeal carcinoma.";
RL   Int. J. Cancer 31:587-590(1983).
RX   PubMed=17062557; DOI=10.1158/0008-5472.CAN-06-2977;
RA   Qian C.-N., Berghuis B., Tsarfaty G., Bruch M., Kort E.J., Ditlev J.,
RA   Tsarfaty I., Hudson E., Jackson D.G., Petillo D., Chen J.-D.,
RA   Resau J.H., Teh B.T.;
RT   "Preparing the 'soil': the primary tumor induces vasculature
RT   reorganization in the sentinel lymph node before the arrival of
RT   metastatic cancer cells.";
RL   Cancer Res. 66:10365-10376(2006).
RX   PubMed=18196576; DOI=10.1002/ijc.23374;
RA   Chan S.Y.-Y., Choy K.-W., Tsao S.-W., Tao Q., Tang T., Chung G.T.-Y.,
RA   Lo K.-W.;
RT   "Authentication of nasopharyngeal carcinoma tumor lines.";
RL   Int. J. Cancer 122:2169-2171(2008).
RX   PubMed=20406978; DOI=10.1158/0008-5472.CAN-09-4099;
RA   Feng X.-P., Yi H., Li M.-Y., Li X.-H., Yi B., Zhang P.-F., Li C.,
RA   Peng F., Tang C.-E., Li J.-L., Chen Z.-C., Xiao Z.-Q.;
RT   "Identification of biomarkers for predicting nasopharyngeal carcinoma
RT   response to radiotherapy by proteomics.";
RL   Cancer Res. 70:3450-3462(2010).
RX   PubMed=24991015; DOI=10.1128/JVI.01457-14;
RA   Strong M.J., Baddoo M., Nanbo A., Xu M., Puetter A., Lin Z.;
RT   "Comprehensive RNA-seq analysis reveals contamination of multiple
RT   nasopharyngeal carcinoma cell lines with HeLa cell genomes.";
RL   J. Virol. 88:10696-10704(2014).
RX   PubMed=25028967; DOI=10.1371/journal.pone.0100843;
RA   Liang Y.-Y., Chen M.-Y., Hua Y.-J., Chen S., Zheng L.-S., Cao X.,
RA   Peng L.-X., Xie P., Huang B.-J., Sun R., Wang L., Xiang Y.-Q., Guo X.,
RA   Qian C.-N.;
RT   "Downregulation of Ras association domain family member 6 (RASSF6)
RT   underlies the treatment resistance of highly metastatic nasopharyngeal
RT   carcinoma cells.";
RL   PLoS ONE 9:E100843-E100843(2014).