ID   CNE-2
AC   CVCL_6889
SY   CNE2
DR   BTO; BTO_0005250
DR   BioSample; SAMN06481109
DR   cancercelllines; CVCL_6889
DR   CCTCC; GDC0155
DR   ChEMBL-Cells; CHEMBL4295476
DR   ChEMBL-Targets; CHEMBL4296409
DR   Cosmic; 755505
DR   Cosmic; 923774
DR   Cosmic; 944910
DR   Cosmic; 1017619
DR   Cosmic; 1300999
DR   Cosmic; 1322947
DR   Cosmic; 2366880
DR   GEO; GSM375846
DR   Progenetix; CVCL_6889
DR   PubChem_Cell_line; CVCL_6889
DR   Wikidata; Q54813874
RX   CelloPub=CLPUB00143;
RX   CelloPub=CLPUB00484;
RX   PubMed=6852976;
RX   PubMed=17062557;
RX   PubMed=18196576;
RX   PubMed=20406978;
RX   PubMed=24991015;
RX   PubMed=25028967;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. On the basis of the STR profile (PubMed=18196576) it is identical to CNE-1 and seems to be a hybrid of HeLa and of cell line of unknown origin. Originally thought to originate from a 68 year old male patient with a nasopharyngeal carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00474.
CC   Omics: Transcriptomics; RNAseq.
ST   Source(s): PubMed=18196576
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 10,12,13.3
ST   D16S539: 9,10
ST   D18S51: 13,16
ST   D19S433: 13
ST   D21S11: 27,30
ST   D2S1338: 17,23
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   D8S1179: 12,17
ST   FGA: 18,21
ST   TH01: 6,7,9
ST   TPOX: 8,9,12
ST   vWA: 14,16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
CA   Hybrid cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 27
CH   CVCL_6890 ! CNE-2Z
CH   CVCL_C9B8 ! CNE2-IR
CH   CVCL_B0U9 ! S18
CH   CVCL_B0UB ! S26
//
RX   PubMed=6852976; DOI=10.1002/ijc.2910310509;
RA   Zhang, Si-Zhong
RA   Gao, Xiu-Kung
RA   Zeng, Yi
RT   "Cytogenetic studies on an epithelial cell line derived from poorly
RT   differentiated nasopharyngeal carcinoma.";
RL   Int. J. Cancer 31:587-590(1983).
//
RX   PubMed=18196576; DOI=10.1002/ijc.23374;
RA   Chan, Sylvia Yat-Yee
RA   Choy, Kwong-Wai
RA   Tsao, George Sai-Wah
RA   Tao, Qian
RA   Tang, Tao
RA   Chung, Grace Tin-Yun
RA   Lo, Kwok-Wai
RT   "Authentication of nasopharyngeal carcinoma tumor lines.";
RL   Int. J. Cancer 122:2169-2171(2008).
//
RX   CelloPub=CLPUB00143;
RA   Zhang, Si-Zhong
RA   Gao, Xiu-Kung
RA   Zeng, Yi
RT   "Cytogenetic studies on an epithelial cell line derived from poorly
RT   differentiated nasopharyngeal carcinoma.";
RL   Yi Chuan Xue Bao 10:498-503(1983).
//
RX   PubMed=24991015; DOI=10.1128/JVI.01457-14; PMCID=PMC4178894;
RA   Strong, Michael J.
RA   Baddoo, Melody
RA   Nanbo, Asuka
RA   Xu, Miao
RA   Puetter, Adriane
RA   Lin, Zhen
RT   "Comprehensive high-throughput RNA sequencing analysis reveals
RT   contamination of multiple nasopharyngeal carcinoma cell lines
RT   with HeLa cell genomes.";
RL   J. Virol. 88:10696-10704(2014).
//
RX   PubMed=25028967; DOI=10.1371/journal.pone.0100843; PMCID=PMC4100732;
RA   Liang, Ying-Ying
RA   Chen, Ming-Yuan
RA   Hua, Yi-Jun
RA   Chen, Shi
RA   Zheng, Li-Sheng
RA   Cao, Xue
RA   Peng, Li-Xia
RA   Xie, Ping
RA   Huang, Bi-Jun
RA   Sun, Rui
RA   Wang, Lin
RA   Xiang, Yan-Qun
RA   Guo, Xiang
RA   Qian, Chao-Nan
RT   "Downregulation of Ras association domain family member 6 (RASSF6)
RT   underlies the treatment resistance of highly metastatic nasopharyngeal
RT   carcinoma cells.";
RL   PLoS ONE 9:e100843.1-e100843.9(2014).
//
RX   CelloPub=CLPUB00484;
RA   Xu, Zhi-Hong
RA   Sun, Wen-Wen
RA   Hang, Jun-Biao
RA   Gao, Bei-Li
RA   Hu, Jia-An
RT   "RNA-seq identified a novel functional MET fusion in head and neck
RT   cancer 5-8F cell line.";
RL   Int. J. Clin. Exp. Pathol. 9:8308-8317(2016).
//
RX   PubMed=20406978; DOI=10.1158/0008-5472.CAN-09-4099;
RA   Feng, Xue-Ping
RA   Yi, Hong
RA   Li, Mao-Yu
RA   Li, Xin-Hui
RA   Yi, Bin
RA   Zhang, Peng-Fei
RA   Li, Cui
RA   Peng, Fang
RA   Tang, Can-E
RA   Li, Jian-Ling
RA   Chen, Zhu-Chu
RA   Xiao, Zhi-Qiang
RT   "Identification of biomarkers for predicting nasopharyngeal carcinoma
RT   response to radiotherapy by proteomics.";
RL   Cancer Res. 70:3450-3462(2010).
//
RX   PubMed=17062557; DOI=10.1158/0008-5472.CAN-06-2977;
RA   Qian, Chao-Nan
RA   Berghuis, Bree
RA   Tsarfaty, Galia
RA   Bruch, MaryBeth
RA   Kort, Eric Jon
RA   Ditlev, Jon
RA   Tsarfaty, Ilan
RA   Hudson, Eric
RA   Jackson, David G.
RA   Petillo, David
RA   Chen, Jin-Dong
RA   Resau, James Howard
RA   Teh, Bin Tean
RT   "Preparing the 'soil': the primary tumor induces vasculature
RT   reorganization in the sentinel lymph node before the arrival of
RT   metastatic cancer cells.";
RL   Cancer Res. 66:10365-10376(2006).
//