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Cellosaurus A375-P (CVCL_6233)

[Text version]
Cell line name A375-P
Synonyms A-375P; A375P; A375p
Accession CVCL_6233
Resource Identification Initiative To cite this cell line use: A375-P (RRID:CVCL_6233)
Comments Population: Caucasian.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
CVCL_C0RN (A375M1)CVCL_RN37 (A375P-5)CVCL_5F66 (A375P-beta6/puro)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3224


Run an STR similarity search on this cell line

PubMed=2731157; DOI=10.1016/0304-3835(89)90148-1
Yohem K.H., Seftor E.A., Meyskens F.L. Jr., Hendrix M.J.C.
Cloning efficiency of human melanoma cells is modulated after invasion through a reconstituted basement membrane.
Cancer Lett. 45:135-143(1989)

PubMed=1671030; DOI=10.1002/ijc.2910470211
Welch D.R., Bisi J.E., Miller B.E., Conaway D.H., Seftor E.A., Yohem K.H., Gilmore L.B., Seftor R.E.B., Nakajima M., Hendrix M.J.C.
Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line.
Int. J. Cancer 47:227-237(1991)

PubMed=22323893; DOI=10.3109/10623329609024685
Sriramarao P., Bourdon M.A.
Melanoma cell invasive and metastatic potential correlates with endothelial cell reorganization and tenascin expression.
Endothelium 4:85-97(1996)

PubMed=10952316; DOI=10.1038/35020106
Clark E.A., Golub T.R., Lander E.S., Hynes R.O.
Genomic analysis of metastasis reveals an essential role for RhoC.
Nature 406:532-535(2000)

Cell line collections (Providers) ATCC; CRL-3224
KCLB; 80003
Cell line databases/resources cancercelllines; CVCL_6233
Anatomy/cell type resources BTO; BTO:0003984
Chemistry resources ChEMBL-Cells; CHEMBL4879545
Encyclopedic resources Wikidata; Q54606807
Polymorphism and mutation databases Cosmic; 932714
Cosmic; 1045406
Cosmic; 1067223
Cosmic; 1238110
Proteomic databases PRIDE; PXD005277
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number25