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Cellosaurus A375P-beta6/puro (CVCL_5F66)

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Cell line name A375P-beta6/puro
Synonyms A375Pbeta6puro
Accession CVCL_5F66
Resource Identification Initiative To cite this cell line use: A375P-beta6/puro (RRID:CVCL_5F66)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6161; ITGB6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6233 (A375-P)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=17244604; DOI=10.1074/jbc.M610461200
Danielle DiCara, Chiara Rapisarda, Julie L. Sutcliffe, Shelia M. Violette, Paul Henry Weinreb, Ian R. Hart, Mark J. Howard, John F. Marshall;
Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands.
J. Biol. Chem. 282:9657-9665(2007)

Cross-references
Cell line collections (Providers) CancerTools; 151626
Ximbio; 151626
Cell line databases/resources cancercelllines; CVCL_5F66
Encyclopedic resources Wikidata; Q54606874
Entry history
Entry creation14-Dec-2015
Last entry update14-Aug-2025
Version number18