ID   A375P-beta6/puro
AC   CVCL_5F66
SY   A375Pbeta6puro
DR   cancercelllines; CVCL_5F66
DR   CancerTools; 151626
DR   Wikidata; Q54606874
DR   Ximbio; 151626
RX   PubMed=17244604;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6161; ITGB6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6233 ! A375-P
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 14-08-25; Version: 18
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RX   PubMed=17244604; DOI=10.1074/jbc.M610461200;
RA   DiCara, Danielle
RA   Rapisarda, Chiara
RA   Sutcliffe, Julie L.
RA   Violette, Shelia M.
RA   Weinreb, Paul Henry
RA   Hart, Ian R.
RA   Howard, Mark J.
RA   Marshall, John F.
RT   "Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v
RT   beta 6 integrin ligands.";
RL   J. Biol. Chem. 282:9657-9665(2007).
//