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Cellosaurus GLC-4/ADR (CVCL_4997)

[Text version]
Cell line name GLC-4/ADR
Synonyms GLC4-Adr; GLC4/ADR; GLC(4)/ADR; GLC4/ADR350x; GLC4-ADR150; GLC4-Adr1
Accession CVCL_4997
Resource Identification Initiative To cite this cell line use: GLC-4/ADR (RRID:CVCL_4997)
Comments Doubling time: 26 hours (PubMed=3028613).
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Unspecified (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0279 (GLC-4)
Children:
CVCL_A5AZ (GLC-4/ADRpr)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=3028613
Jan G. Zijlstra, Elisabeth Geertruida Emma de Vries, Nanno H. Mulder;
Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.
Cancer Res. 47:1780-1784(1987)

PubMed=3040227
Coby Meijer, Nanno H. Mulder, Hetty Timmer-Bosscha, Jan G. Zijlstra, Elisabeth Geertruida Emma de Vries;
Role of free radicals in an adriamycin-resistant human small cell lung cancer cell line.
Cancer Res. 47:4613-4617(1987)

PubMed=1657425; DOI=10.1007/BF00685823
Steven de Jong, Jan G. Zijlstra, Nanno H. Mulder, Elisabeth Geertruida Emma de Vries;
Lack of cross-resistance to fostriecin in a human small-cell lung carcinoma cell line showing topoisomerase II-related drug resistance.
Cancer Chemother. Pharmacol. 28:461-464(1991)

PubMed=7809167; DOI=10.1073/pnas.91.26.13033; PMCID=PMC45575
Michael Muller, Coby Meijer, Guido J.R. Zaman, Piet Borst, Riekeld J. Scheper, Nanno H. Mulder, Elisabeth Geertruida Emma de Vries, Peter L.M. Jansen;
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.
Proc. Natl. Acad. Sci. U.S.A. 91:13033-13037(1994)

PubMed=7729950; DOI=10.1002/ijc.2910610317
Carolina H.M. Versantvoort, Sebo Withoff, Henk J. Broxterman, Catharina M. Kuiper, Riekeld J. Scheper, Nanno H. Mulder, Elisabeth Geertruida Emma de Vries;
Resistance-associated factors in human small-cell lung-carcinoma GLC4 sub-lines with increasing adriamycin resistance.
Int. J. Cancer 61:375-380(1995)

PubMed=8980384; DOI=10.1038/bjc.1996.647; PMCID=PMC2074800
Sebo Withoff, Elisabeth Geertruida Emma de Vries, W. Nicol Keith, Edith F. Nienhuis, Winette T.A. van der Graaf, Donald Robert Alexander Uges, Nanno H. Mulder;
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
Br. J. Cancer 74:1869-1876(1996)

PubMed=11309308
Marc Maliepaard, George L. Scheffer, Ian F. Faneyte, Margot A. van Gastelen, Adriana C.L.M. Pijnenborg, Alfred H. Schinkel, Marc Joan van de Vijver, Riekeld J. Scheper, Jan H.M. Schellens;
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Cancer Res. 61:3458-3464(2001)

Cross-references
Anatomy/cell type resources BTO; BTO_0002386
Chemistry resources ChEMBL-Cells; CHEMBL3833703
PubChem_Cell_line; CVCL_4997
Encyclopedic resources Wikidata; Q54835913
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number18