ID   GLC-4/ADR
AC   CVCL_4997
SY   GLC4-Adr; GLC4/ADR; GLC(4)/ADR; GLC4/ADR350x; GLC4-ADR150; GLC4-Adr1
DR   BTO; BTO_0002386
DR   ChEMBL-Cells; CHEMBL3833703
DR   PubChem_Cell_line; CVCL_4997
DR   Wikidata; Q54835913
RX   PubMed=1657425;
RX   PubMed=3028613;
RX   PubMed=3040227;
RX   PubMed=7729950;
RX   PubMed=7809167;
RX   PubMed=8980384;
RX   PubMed=11309308;
CC   Doubling time: 26 hours (PubMed=3028613).
CC   Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0279 ! GLC-4
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 18
CH   CVCL_A5AZ ! GLC-4/ADRpr
//
RX   PubMed=7809167; DOI=10.1073/pnas.91.26.13033; PMCID=PMC45575;
RA   Muller, Michael
RA   Meijer, Coby
RA   Zaman, Guido J.R.
RA   Borst, Piet
RA   Scheper, Riekeld J.
RA   Mulder, Nanno H.
RA   de Vries, Elisabeth Geertruida Emma
RA   Jansen, Peter L.M.
RT   "Overexpression of the gene encoding the multidrug
RT   resistance-associated protein results in increased ATP-dependent
RT   glutathione S-conjugate transport.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:13033-13037(1994).
//
RX   PubMed=11309308;
RA   Maliepaard, Marc
RA   Scheffer, George L.
RA   Faneyte, Ian F.
RA   van Gastelen, Margot A.
RA   Pijnenborg, Adriana C.L.M.
RA   Schinkel, Alfred H.
RA   van de Vijver, Marc Joan
RA   Scheper, Riekeld J.
RA   Schellens, Jan H.M.
RT   "Subcellular localization and distribution of the breast cancer
RT   resistance protein transporter in normal human tissues.";
RL   Cancer Res. 61:3458-3464(2001).
//
RX   PubMed=3040227;
RA   Meijer, Coby
RA   Mulder, Nanno H.
RA   Timmer-Bosscha, Hetty
RA   Zijlstra, Jan G.
RA   de Vries, Elisabeth Geertruida Emma
RT   "Role of free radicals in an adriamycin-resistant human small cell
RT   lung cancer cell line.";
RL   Cancer Res. 47:4613-4617(1987).
//
RX   PubMed=3028613;
RA   Zijlstra, Jan G.
RA   de Vries, Elisabeth Geertruida Emma
RA   Mulder, Nanno H.
RT   "Multifactorial drug resistance in an adriamycin-resistant human small
RT   cell lung carcinoma cell line.";
RL   Cancer Res. 47:1780-1784(1987).
//
RX   PubMed=8980384; DOI=10.1038/bjc.1996.647; PMCID=PMC2074800;
RA   Withoff, Sebo
RA   de Vries, Elisabeth Geertruida Emma
RA   Keith, William Nicol
RA   Nienhuis, Edith F.
RA   van der Graaf, Winette T.A.
RA   Uges, Donald Robert Alexander
RA   Mulder, Nanno H.
RT   "Differential expression of DNA topoisomerase II alpha and -beta in
RT   P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines
RT   of the human SCLC cell line GLC4.";
RL   Br. J. Cancer 74:1869-1876(1996).
//
RX   PubMed=7729950; DOI=10.1002/ijc.2910610317;
RA   Versantvoort, Carolina H.M.
RA   Withoff, Sebo
RA   Broxterman, Henk J.
RA   Kuiper, Catharina M.
RA   Scheper, Riekeld J.
RA   Mulder, Nanno H.
RA   de Vries, Elisabeth Geertruida Emma
RT   "Resistance-associated factors in human small-cell lung-carcinoma GLC4
RT   sub-lines with increasing adriamycin resistance.";
RL   Int. J. Cancer 61:375-380(1995).
//
RX   PubMed=1657425; DOI=10.1007/BF00685823;
RA   de Jong, Steven
RA   Zijlstra, Jan G.
RA   Mulder, Nanno H.
RA   de Vries, Elisabeth Geertruida Emma
RT   "Lack of cross-resistance to fostriecin in a human small-cell lung
RT   carcinoma cell line showing topoisomerase II-related drug resistance.";
RL   Cancer Chemother. Pharmacol. 28:461-464(1991).
//