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Cellosaurus GLC-4 (CVCL_0279)

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Cell line name GLC-4
Synonyms GLC 4; GLC4
Accession CVCL_0279
Resource Identification Initiative To cite this cell line use: GLC-4 (RRID:CVCL_0279)
Comments Doubling time: 26 hours (PubMed=3028613); 16.9 hours (PubMed=8980384).
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4997 (GLC-4/ADR)CVCL_Y299 (GLC-4/AM3x)CVCL_4998 (GLC-4/CDDP)
CVCL_Y297 (GLC-4/CDDP11)CVCL_Y298 (GLC-4/CDDP3)CVCL_4999 (GLC-4/MIT60x)
CVCL_Y301 (GLC-4/VM20x)CVCL_C5RI (GLC4/Sb30)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=3028613
Jan G. Zijlstra, Elisabeth Geertruida Emma de Vries, Nanno H. Mulder;
Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.
Cancer Res. 47:1780-1784(1987)

PubMed=3040227
Coby Meijer, Nanno H. Mulder, Hetty Timmer-Bosscha, Jan G. Zijlstra, Elisabeth Geertruida Emma de Vries;
Role of free radicals in an adriamycin-resistant human small cell lung cancer cell line.
Cancer Res. 47:4613-4617(1987)

PubMed=1657425; DOI=10.1007/BF00685823
Steven de Jong, Jan G. Zijlstra, Nanno H. Mulder, Elisabeth Geertruida Emma de Vries;
Lack of cross-resistance to fostriecin in a human small-cell lung carcinoma cell line showing topoisomerase II-related drug resistance.
Cancer Chemother. Pharmacol. 28:461-464(1991)

PubMed=1320893; DOI=10.1159/000163712
Marken A.E. Verbeeck, Jack P.M. Elands, Lou F.M.H. de Leij, Charles H.C.M. Buys, Desmond Niall Carney, Gerold Bepler, Anton J.M. Roebroek, Wim J.M. van de Ven, J. Peter H. Burbach;
Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.
Pathobiology 60:136-142(1992)

PubMed=8980384; DOI=10.1038/bjc.1996.647; PMCID=PMC2074800
Sebo Withoff, Elisabeth Geertruida Emma de Vries, W. Nicol Keith, Edith F. Nienhuis, Winette T.A. van der Graaf, Donald Robert Alexander Uges, Nanno H. Mulder;
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
Br. J. Cancer 74:1869-1876(1996)

PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0
Lois M. Mulligan, Tineke Timmer, Stacey M. Ivanchuk, Barbara G. Campling, Leah C. Young, Pamela H. Rabbitts, Vasi Sundaresan, Robert M.W. Hofstra, Charis Eng;
Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma.
Genes Chromosomes Cancer 21:326-332(1998)

PubMed=10025956; DOI=10.1016/S0014-5793(98)01716-5
Laurent Vernhet, Arnaud Courtois, Nathalie Allain, Lea Payen, Jean-Pierre Anger, Andre Guillouzo, Olivier Fardel;
Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells.
FEBS Lett. 443:321-325(1999)

PubMed=10408787; DOI=10.1097/00019606-199903000-00002
Vanessa M. Hayes, Wim Bleeker, Edwin Verlind, Tineke Timmer, Arend Karrenbeld, John T. Plukker, Munro Peter Marx, Robert M.W. Hofstra, Charles H.C.M. Buys;
Comprehensive TP53-denaturing gradient gel electrophoresis mutation detection assay also applicable to archival paraffin-embedded tissue.
Diagn. Mol. Pathol. 8:2-10(1999)

PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O
Pamela M.J. McLaughlin, Wijnand Helfrich, Klaas Kok, Marcel Mulder, Soesja W. Hu, Marja G.L. Brinker, Marcel H.J. Ruiters, Lou F.M.H. de Leij, Charles H.C.M. Buys;
The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.
Int. J. Cancer 85:871-876(2000)

PubMed=15150577; DOI=10.1038/sj.bjc.6601863; PMCID=PMC2409533
Ronald Boonstra, Hetty Timmer-Bosscha, Jannie van Echten-Arends, Dorina M. van der Kolk, Anke van den Berg, Bauke de Jong, Kenneth D. Tew, Sibrandes Poppema, Elisabeth Geertruida Emma de Vries;
Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation.
Br. J. Cancer 90:2411-2417(2004)

PubMed=20615970; DOI=10.1073/pnas.1008132107; PMCID=PMC2919980
Johannes Voortman, Jih-Hsiang Lee, Jonathan Keith Killian, Miia Suuriniemi, Yong-Hong Wang, Marco Lucchi, William I. Smith Jr., Paul S. Meltzer, Yi-Song Wang, Giuseppe Giaccone;
Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.
Proc. Natl. Acad. Sci. U.S.A. 107:13040-13045(2010)

Cross-references
Cell line databases/resources MCCL; MCC:0000170
cancercelllines; CVCL_0279
Anatomy/cell type resources BTO; BTO_0002385
Chemistry resources ChEMBL-Cells; CHEMBL3307807
ChEMBL-Targets; CHEMBL612707
PubChem_Cell_line; CVCL_0279
Encyclopedic resources Wikidata; Q54835912
Gene expression databases GEO; GSM536324
Polymorphism and mutation databases Cosmic; 1429646
Cosmic; 1998274
Cosmic; 2239121
IARC_TP53; 11273
Progenetix; CVCL_0279
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24