ID GLC-4 AC CVCL_0279 SY GLC 4; GLC4 DR BTO; BTO_0002385 DR MCCL; MCC:0000170 DR cancercelllines; CVCL_0279 DR ChEMBL-Cells; CHEMBL3307807 DR ChEMBL-Targets; CHEMBL612707 DR Cosmic; 1429646 DR Cosmic; 1998274 DR Cosmic; 2239121 DR GEO; GSM536324 DR IARC_TP53; 11273 DR Progenetix; CVCL_0279 DR PubChem_Cell_line; CVCL_0279 DR Wikidata; Q54835912 RX PubMed=1320893; RX PubMed=1657425; RX PubMed=2846161; RX PubMed=3028613; RX PubMed=3040227; RX PubMed=8980384; RX PubMed=9559344; RX PubMed=10025956; RX PubMed=10408787; RX PubMed=10709110; RX PubMed=15150577; RX PubMed=20615970; CC Doubling time: 24 +- 1.4 hours (PubMed=2846161); 26 hours (PubMed=3028613); 16.9 hours (PubMed=8980384). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Unspecified (PubMed=10408787). CC Omics: Variations; Array-based CGH. CC Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. DI NCIt; C4917; Lung small cell carcinoma DI ORDO; Orphanet_70573; Small cell lung cancer OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG Age unspecified CA Cancer cell line DT Created: 04-04-12; Last updated: 27-11-25; Version: 25 CH CVCL_4997 ! GLC-4/ADR CH CVCL_Y299 ! GLC-4/AM3x CH CVCL_4998 ! GLC-4/CDDP CH CVCL_Y297 ! GLC-4/CDDP11 CH CVCL_Y298 ! GLC-4/CDDP3 CH CVCL_4999 ! GLC-4/MIT60x CH CVCL_Y301 ! GLC-4/VM20x CH CVCL_C5RI ! GLC4/Sb30 // RX PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0; RA Mulligan, Lois M. RA Timmer, Tineke RA Ivanchuk, Stacey M. RA Campling, Barbara G. RA Young, Leah C. RA Rabbitts, Pamela Helen RA Sundaresan, Vasi RA Hofstra, Robert M.W. RA Eng, Charis RT "Investigation of the genes for RET and its ligand complex, GDNF/GFR RT alpha-I, in small cell lung carcinoma."; RL Genes Chromosomes Cancer 21:326-332(1998). // RX PubMed=1320893; DOI=10.1159/000163712; RA Verbeeck, Marken A.E. RA Elands, Jack P.M. RA de Leij, Lou F.M.H. RA Buys, Charles H.C.M. RA Carney, Desmond Niall RA Bepler, Gerold RA Roebroek, Anton J.M. RA van de Ven, Wim J.M. RA Burbach, J. Peter H. RT "Expression of the vasopressin and gastrin-releasing peptide genes in RT small cell lung carcinoma cell lines."; RL Pathobiology 60:136-142(1992). // RX PubMed=3040227; RA Meijer, Coby RA Mulder, Nanno H. RA Timmer-Bosscha, Hetty RA Zijlstra, Jan G. RA de Vries, Elisabeth Geertruida Emma RT "Role of free radicals in an adriamycin-resistant human small cell RT lung cancer cell line."; RL Cancer Res. 47:4613-4617(1987). // RX PubMed=3028613; RA Zijlstra, Jan G. RA de Vries, Elisabeth Geertruida Emma RA Mulder, Nanno H. RT "Multifactorial drug resistance in an adriamycin-resistant human small RT cell lung carcinoma cell line."; RL Cancer Res. 47:1780-1784(1987). // RX PubMed=2846161; RA Hospers, Geke A.P. RA Mulder, Nanno H. RA de Jong, Bauke RA de Leij, Lou F.M.H. RA Uges, Donald Robert Alexander RA Fichtinger-Schepman, Anne Marie Josephine RA Scheper, Riekeld J. RA de Vries, Elisabeth Geertruida Emma RT "Characterization of a human small cell lung carcinoma cell line with RT acquired resistance to cis-diamminedichloroplatinum(II) in vitro."; RL Cancer Res. 48:6803-6807(1988). // RX PubMed=8980384; DOI=10.1038/bjc.1996.647; PMCID=PMC2074800; RA Withoff, Sebo RA de Vries, Elisabeth Geertruida Emma RA Keith, William Nicol RA Nienhuis, Edith F. RA van der Graaf, Winette T.A. RA Uges, Donald Robert Alexander RA Mulder, Nanno H. RT "Differential expression of DNA topoisomerase II alpha and -beta in RT P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines RT of the human SCLC cell line GLC4."; RL Br. J. Cancer 74:1869-1876(1996). // RX PubMed=10408787; DOI=10.1097/00019606-199903000-00002; RA Hayes, Vanessa M. RA Bleeker, Wim RA Verlind, Edwin RA Timmer, Tineke RA Karrenbeld, Arend RA Plukker, John T. RA Marx, Munro Peter RA Hofstra, Robert M.W. RA Buys, Charles H.C.M. RT "Comprehensive TP53-denaturing gradient gel electrophoresis mutation RT detection assay also applicable to archival paraffin-embedded RT tissue."; RL Diagn. Mol. Pathol. 8:2-10(1999). // RX PubMed=1657425; DOI=10.1007/BF00685823; RA de Jong, Steven RA Zijlstra, Jan G. RA Mulder, Nanno H. RA de Vries, Elisabeth Geertruida Emma RT "Lack of cross-resistance to fostriecin in a human small-cell lung RT carcinoma cell line showing topoisomerase II-related drug resistance."; RL Cancer Chemother. Pharmacol. 28:461-464(1991). // RX PubMed=15150577; DOI=10.1038/sj.bjc.6601863; PMCID=PMC2409533; RA Boonstra, Ronald RA Timmer-Bosscha, Hetty RA van Echten-Arends, Jannie RA van der Kolk, Dorina M. RA van den Berg, Anke RA de Jong, Bauke RA Tew, Kenneth D. RA Poppema, Sibrandes RA de Vries, Elisabeth Geertruida Emma RT "Mitoxantrone resistance in a small cell lung cancer cell line is RT associated with ABCA2 upregulation."; RL Br. J. Cancer 90:2411-2417(2004). // RX PubMed=20615970; DOI=10.1073/pnas.1008132107; PMCID=PMC2919980; RA Voortman, Johannes RA Lee, Jih-Hsiang RA Killian, Jonathan Keith RA Suuriniemi, Miia RA Wang, Yong-Hong RA Lucchi, Marco RA Smith, William I. Jr. RA Meltzer, Paul S. RA Wang, Yi-Song RA Giaccone, Giuseppe RT "Array comparative genomic hybridization-based characterization of RT genetic alterations in pulmonary neuroendocrine tumors."; RL Proc. Natl. Acad. Sci. U.S.A. 107:13040-13045(2010). // RX PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O; RA McLaughlin, Pamela M.J. RA Helfrich, Wijnand RA Kok, Klaas RA Mulder, Marcel RA Hu, Soesja W. RA Brinker, Marja G.L. RA Ruiters, Marcel H.J. RA de Leij, Lou F.M.H. RA Buys, Charles H.C.M. RT "The ubiquitin-activating enzyme E1-like protein in lung cancer cell RT lines."; RL Int. J. Cancer 85:871-876(2000). // RX PubMed=10025956; DOI=10.1016/S0014-5793(98)01716-5; RA Vernhet, Laurent RA Courtois, Arnaud RA Allain, Nathalie RA Payen, Lea RA Anger, Jean-Pierre RA Guillouzo, Andre RA Fardel, Olivier RT "Overexpression of the multidrug resistance-associated protein (MRP1) RT in human heavy metal-selected tumor cells."; RL FEBS Lett. 443:321-325(1999). //