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Cellosaurus GLC-4/MIT60x (CVCL_4999)

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Cell line name GLC-4/MIT60x
Synonyms GLC4/MIT60X; GLC4-MITO; GLC4/MITO; GLC-4/MITO
Accession CVCL_4999
Secondary accession CVCL_Y300
Resource Identification Initiative To cite this cell line use: GLC-4/MIT60x (RRID:CVCL_4999)
Comments Doubling time: 16.9 hours (PubMed=8980384).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Unspecified (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0279 (GLC-4)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=8980384; DOI=10.1038/bjc.1996.647; PMCID=PMC2074800
Sebo Withoff, Elisabeth Geertruida Emma de Vries, William Nicol Keith, Edith F. Nienhuis, Winette T.A. van der Graaf, Donald Robert Alexander Uges, Nanno H. Mulder;
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
Br. J. Cancer 74:1869-1876(1996)

PubMed=15150577; DOI=10.1038/sj.bjc.6601863; PMCID=PMC2409533
Ronald Boonstra, Hetty Timmer-Bosscha, Jannie van Echten-Arends, Dorina M. van der Kolk, Anke van den Berg, Bauke de Jong, Kenneth D. Tew, Sibrandes Poppema, Elisabeth Geertruida Emma de Vries;
Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation.
Br. J. Cancer 90:2411-2417(2004)

Cross-references
Anatomy/cell type resources BTO; BTO_0002387
Encyclopedic resources Wikidata; Q54835918
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number17