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Cellosaurus GLC-4/ADRpr (CVCL_A5AZ)

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Cell line name GLC-4/ADRpr
Synonyms GLC4/ADRpr; GLC4-Adr2
Accession CVCL_A5AZ
Resource Identification Initiative To cite this cell line use: GLC-4/ADRpr (RRID:CVCL_A5AZ)
Comments Characteristics: Partial revertant of GLC-4/ADR obtained after culturing in drug-free medium for a number of months (3 according to PubMed=3040227 and 6 according to PubMed=7809167).
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Unspecified (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4997 (GLC-4/ADR)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=3040227
Coby Meijer, Nanno H. Mulder, Hetty Timmer-Bosscha, Jan G. Zijlstra, Elisabeth Geertruida Emma de Vries;
Role of free radicals in an adriamycin-resistant human small cell lung cancer cell line.
Cancer Res. 47:4613-4617(1987)

PubMed=7809167; DOI=10.1073/pnas.91.26.13033; PMCID=PMC45575
Michael Muller, Coby Meijer, Guido J.R. Zaman, Piet Borst, Riekeld J. Scheper, Nanno H. Mulder, Elisabeth Geertruida Emma de Vries, Peter L.M. Jansen;
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.
Proc. Natl. Acad. Sci. U.S.A. 91:13033-13037(1994)

Cross-references
Encyclopedic resources Wikidata; Q107115108
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number6