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Cellosaurus 41M (CVCL_4993)

[Text version]
Cell line name 41M
Synonyms 41-M; OAW41M; 041M; 41 M
Accession CVCL_4993
Resource Identification Initiative To cite this cell line use: 41M (RRID:CVCL_4993)
Comments Problematic cell line: Contaminated. Shown to be a OAW28 derivative (PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00110.
Population: Caucasian.
Doubling time: 27 hours (PubMed=2653399).
Omics: Transcriptomics; Microarray.
Misspelling: M41; GEO=GSM851922.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Unspecified (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1614 (OAW28)
Children:
CVCL_N788 (41M-cisR)CVCL_Y427 (41M:RD1694)CVCL_Y037 (41M47)
Sex of cell Female
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): PubMed=22710073

Markers:
AmelogeninX
CSF1PO11
D2S133820,23
D3S135814,18
D5S81812
D7S82011
D8S117911,15
D13S31711
D16S53913
D18S5112,14
D19S43313
D21S1129
FGA21,24
TH019
TPOX8
vWA19

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=2653399; DOI=10.1038/bjc.1989.108; PMCID=PMC2247140
Celia A. Hills, Lloyd R. Kelland, George Abel, Jan Siracky, Anne P. Wilson, Kenneth Reginald Harrap;
Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes.
Br. J. Cancer 59:527-534(1989)

PubMed=1892748; DOI=10.1038/bjc.1991.279; PMCID=PMC1977519
Prakash Mistry, Lloyd R. Kelland, George Abel, Sanjiv Sidhar, Kenneth Reginald Harrap;
The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines.
Br. J. Cancer 64:215-220(1991)

PubMed=1423261
Prakash Mistry, Lloyd R. Kelland, Swee Y. Loh, George Abel, Barry A. Murrer, Kenneth Reginald Harrap;
Comparison of cellular accumulation and cytotoxicity of cisplatin with that of tetraplatin and amminedibutyratodichloro(cyclohexylamine)platinum(IV) (JM221) in human ovarian carcinoma cell lines.
Cancer Res. 52:6188-6193(1992)

PubMed=1617660
Lloyd R. Kelland, Prakash Mistry, George Abel, Swee Y. Loh, Ciaran F. O'Neill, Barry A. Murrer, Kenneth Reginald Harrap;
Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates.
Cancer Res. 52:3857-3864(1992)

PubMed=8795574; DOI=10.1038/bjc.1996.428; PMCID=PMC2074705
Anne P. Wilson, Maria F. Dent, Tanja Pejovic, Linda Hubbold, Heather Radford;
Characterisation of seven human ovarian tumour cell lines.
Br. J. Cancer 74:722-727(1996)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Kylie Louise Gorringe, Suet-Feung Chin, Paul D.P. Pharoah, Joanne M. Staines, Carla Oliveira, Paul A.W. Edwards, Carlos Caldas;
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Britta Stordal, Kirsten Timms, Angela Farrelly, Danielle Gallagher, Steven Busschots, Mickael Renaud, Julien Thery, Deborah Williams, Jennifer Potter, Thanh Tran, Greg Korpanty ...Show all 19 authors... , Mattia Cremona, Mark S. Carey, Jie Li, Yang Li, Ozlem Aslan, John J. O'Leary, Gordon B. Mills, Bryan T. Hennessy; Show fewer authors
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

Cross-references
Cell line collections (Providers) ECACC; 93061002 - Discontinued
Cell line databases/resources cancercelllines; CVCL_4993
Anatomy/cell type resources BTO; BTO_0003998
Biological sample resources BioSample; SAMN03151866
Chemistry resources ChEMBL-Cells; CHEMBL3307631
ChEMBL-Targets; CHEMBL614511
PubChem_Cell_line; CVCL_4993
Encyclopedic resources Wikidata; Q54602996
Gene expression databases GEO; GSM313659
GEO; GSM851922
Polymorphism and mutation databases Progenetix; CVCL_4993
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number34