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Cellosaurus 41M (CVCL_4993)

[Text version]
Cell line name 41M
Synonyms 41-M; OAW41M; 041M; 41 M
Accession CVCL_4993
Resource Identification Initiative To cite this cell line use: 41M (RRID:CVCL_4993)
Comments Problematic cell line: Contaminated. Shown to be a OAW28 derivative (PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00110.
Population: Caucasian.
Doubling time: 27 hours (PubMed=2653399).
Omics: Transcriptome analysis by microarray.
Misspelling: M41; GEO=GSM851922.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Unspecified (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1614 (OAW28)
CVCL_N788 (41M-cisR)CVCL_Y427 (41M:RD1694)CVCL_Y037 (41M47)
Sex of cell Female
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): PubMed=22710073


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=2653399; DOI=10.1038/bjc.1989.108
Hills C.A., Kelland L.R., Abel G., Siracky J., Wilson A.P., Harrap K.R.
Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes.
Br. J. Cancer 59:527-534(1989)

PubMed=1892748; DOI=10.1038/bjc.1991.279
Mistry P., Kelland L.R., Abel G., Sidhar S., Harrap K.R.
The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines.
Br. J. Cancer 64:215-220(1991)

Mistry P., Kelland L.R., Loh S.Y., Abel G., Murrer B.A., Harrap K.R.
Comparison of cellular accumulation and cytotoxicity of cisplatin with that of tetraplatin and amminedibutyratodichloro(cyclohexylamine)platinum(IV) (JM221) in human ovarian carcinoma cell lines.
Cancer Res. 52:6188-6193(1992)

Kelland L.R., Mistry P., Abel G., Loh S.Y., O'Neill C.F., Murrer B.A., Harrap K.R.
Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates.
Cancer Res. 52:3857-3864(1992)

PubMed=8795574; DOI=10.1038/bjc.1996.428
Wilson A.P., Dent M., Pejovic T., Hubbold L., Radford H.
Characterisation of seven human ovarian tumour cell lines.
Br. J. Cancer 74:722-727(1996)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007
Stordal B., Timms K., Farrelly A., Gallagher D., Busschots S., Renaud M., Thery J., Williams D., Potter J., Tran T., Korpanty G., Cremona M., Carey M.S., Li J., Li Y., Aslan O., O'Leary J.J., Mills G.B., Hennessy B.T.
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

Cell line collections (Providers) ECACC; 93061002 - Discontinued
Cell line databases/resources cancercelllines; CVCL_4993
Anatomy/cell type resources BTO; BTO:0003998
Biological sample resources BioSample; SAMN03151866
Chemistry resources ChEMBL-Cells; CHEMBL3307631
ChEMBL-Targets; CHEMBL614511
PubChem_Cell_line; CVCL_4993
Encyclopedic resources Wikidata; Q54602996
Gene expression databases GEO; GSM313659
GEO; GSM851922
Polymorphism and mutation databases Progenetix; CVCL_4993
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number30