ID   41M
AC   CVCL_4993
SY   41-M; OAW41M; 041M; 41 M
DR   BTO; BTO_0003998
DR   BioSample; SAMN03151866
DR   cancercelllines; CVCL_4993
DR   ChEMBL-Cells; CHEMBL3307631
DR   ChEMBL-Targets; CHEMBL614511
DR   ECACC; 93061002
DR   GEO; GSM313659
DR   GEO; GSM851922
DR   Progenetix; CVCL_4993
DR   PubChem_Cell_line; CVCL_4993
DR   Wikidata; Q54602996
RX   PubMed=1423261;
RX   PubMed=1617660;
RX   PubMed=1892748;
RX   PubMed=2653399;
RX   PubMed=8795574;
RX   PubMed=15677628;
RX   PubMed=20143388;
RX   PubMed=22710073;
RX   PubMed=23415752;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a OAW28 derivative (PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00110.
CC   Population: Caucasian.
CC   Doubling time: 27 hours (PubMed=2653399).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Unspecified (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Misspelling: M41; GEO=GSM851922.
CC   Discontinued: ECACC; 93061002; true.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): PubMed=22710073
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11
ST   D16S539: 13
ST   D18S51: 12,14
ST   D19S433: 13
ST   D21S11: 29
ST   D2S1338: 20,23
ST   D3S1358: 14,18
ST   D5S818: 12
ST   D7S820: 11
ST   D8S1179: 11,15
ST   FGA: 21,24
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 19
DI   NCIt; C105555; High grade ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1614 ! OAW28
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 34
CH   CVCL_N788 ! 41M-cisR
CH   CVCL_Y427 ! 41M:RD1694
CH   CVCL_Y037 ! 41M47
//
RX   PubMed=2653399; DOI=10.1038/bjc.1989.108; PMCID=PMC2247140;
RA   Hills, Celia A.
RA   Kelland, Lloyd R.
RA   Abel, George
RA   Siracky, Jan
RA   Wilson, Anne P.
RA   Harrap, Kenneth Reginald
RT   "Biological properties of ten human ovarian carcinoma cell lines:
RT   calibration in vitro against four platinum complexes.";
RL   Br. J. Cancer 59:527-534(1989).
//
RX   PubMed=1617660;
RA   Kelland, Lloyd R.
RA   Mistry, Prakash
RA   Abel, George
RA   Loh, Swee Y.
RA   O'Neill, Ciaran F.
RA   Murrer, Barry A.
RA   Harrap, Kenneth Reginald
RT   "Mechanism-related circumvention of acquired
RT   cis-diamminedichloroplatinum(II) resistance using two pairs of human
RT   ovarian carcinoma cell lines by ammine/amine platinum(IV)
RT   dicarboxylates.";
RL   Cancer Res. 52:3857-3864(1992).
//
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe, Kylie Louise
RA   Chin, Suet-Feung
RA   Pharoah, Paul D.P.
RA   Staines, Joanne M.
RA   Oliveira, Carla
RA   Edwards, Paul A.W.
RA   Caldas, Carlos
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677;
RA   Korch, Christopher T.
RA   Spillman, Monique A.
RA   Jackson, Twila A.
RA   Jacobsen, Britta M.
RA   Murphy, Susan K.
RA   Lessey, Bruce Arthur
RA   Jordan, Virgil Craig
RA   Bradford, Andrew Peter
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=1892748; DOI=10.1038/bjc.1991.279; PMCID=PMC1977519;
RA   Mistry, Prakash
RA   Kelland, Lloyd R.
RA   Abel, George
RA   Sidhar, Sanjiv
RA   Harrap, Kenneth Reginald
RT   "The relationships between glutathione, glutathione-S-transferase and
RT   cytotoxicity of platinum drugs and melphalan in eight human ovarian
RT   carcinoma cell lines.";
RL   Br. J. Cancer 64:215-220(1991).
//
RX   PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023;
RA   Stordal, Britta
RA   Timms, Kirsten
RA   Farrelly, Angela
RA   Gallagher, Danielle
RA   Busschots, Steven
RA   Renaud, Mickael
RA   Thery, Julien
RA   Williams, Deborah
RA   Potter, Jennifer
RA   Tran, Thanh
RA   Korpanty, Greg
RA   Cremona, Mattia
RA   Carey, Mark S.
RA   Li, Jie
RA   Li, Yang
RA   Aslan, Ozlem
RA   O'Leary, John J.
RA   Mills, Gordon B.
RA   Hennessy, Bryan T.
RT   "BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one
RT   functionally deleterious BRCA1 mutation.";
RL   Mol. Oncol. 7:567-579(2013).
//
RX   PubMed=1423261;
RA   Mistry, Prakash
RA   Kelland, Lloyd R.
RA   Loh, Swee Y.
RA   Abel, George
RA   Murrer, Barry A.
RA   Harrap, Kenneth Reginald
RT   "Comparison of cellular accumulation and cytotoxicity of cisplatin
RT   with that of tetraplatin and
RT   amminedibutyratodichloro(cyclohexylamine)platinum(IV) (JM221) in human
RT   ovarian carcinoma cell lines.";
RL   Cancer Res. 52:6188-6193(1992).
//
RX   PubMed=8795574; DOI=10.1038/bjc.1996.428; PMCID=PMC2074705;
RA   Wilson, Anne P.
RA   Dent, Maria F.
RA   Pejovic, Tanja
RA   Hubbold, Linda
RA   Radford, Heather
RT   "Characterisation of seven human ovarian tumour cell lines.";
RL   Br. J. Cancer 74:722-727(1996).
//