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Cellosaurus 41M:RD1694 (CVCL_Y427)

[Text version]
Cell line name 41M:RD1694
Accession CVCL_Y427
Resource Identification Initiative To cite this cell line use: 41M:RD1694 (RRID:CVCL_Y427)
Comments Problematic cell line: Contaminated. Parent cell line (41M) has been shown to be a OAW28 derivative.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:5847; ICI D1694 (Tomudex; ZD1694).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Unspecified (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4993 (41M)
Sex of cell Female
Age at sampling 75Y
Category Cancer cell line

PubMed=7537518; DOI=10.1038/bjc.1995.178
Jackman A.L., Kelland L.R., Kimbell R., Brown M., Gibson W., Aherne G.W., Hardcastle A., Boyle F.T.
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Br. J. Cancer 71:914-924(1995)

Cell line databases/resources cancercelllines; CVCL_Y427
Encyclopedic resources Wikidata; Q54602998
Entry history
Entry creation07-Nov-2014
Last entry update05-Oct-2023
Version number14