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Cellosaurus 41M:RD1694 (CVCL_Y427)

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Cell line name 41M:RD1694
Accession CVCL_Y427
Resource Identification Initiative To cite this cell line use: 41M:RD1694 (RRID:CVCL_Y427)
Comments Problematic cell line: Contaminated. Parent cell line (41M) has been shown to be a OAW28 derivative.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_5847; ICI D1694 (Tomudex; ZD1694).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Unspecified (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4993 (41M)
Sex of cell Female
Age at sampling 75Y
Category Cancer cell line
Publications

PubMed=7537518; DOI=10.1038/bjc.1995.178; PMCID=PMC2033796
Ann L. Jackman, Lloyd R. Kelland, Rosemary Kimbell, Margaret Brown, William Gibson, G. Wynne Aherne, Anthea Hardcastle, Francis Thomas Boyle;
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Br. J. Cancer 71:914-924(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Y427
Encyclopedic resources Wikidata; Q54602998
Entry history
Entry creation07-Nov-2014
Last entry update19-Dec-2024
Version number15