ID   41M:RD1694
AC   CVCL_Y427
DR   cancercelllines; CVCL_Y427
DR   Wikidata; Q54602998
RX   PubMed=7537518;
CC   Problematic cell line: Contaminated. Parent cell line (41M) has been shown to be a OAW28 derivative.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_5847; ICI D1694 (Tomudex; ZD1694).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C105555; High grade ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4993 ! 41M
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 07-11-14; Last updated: 19-12-24; Version: 15
//
RX   PubMed=7537518; DOI=10.1038/bjc.1995.178; PMCID=PMC2033796;
RA   Jackman, Ann L.
RA   Kelland, Lloyd R.
RA   Kimbell, Rosemary
RA   Brown, Margaret
RA   Gibson, William
RA   Aherne, G. Wynne
RA   Hardcastle, Anthea
RA   Boyle, Francis Thomas
RT   "Mechanisms of acquired resistance to the quinazoline thymidylate
RT   synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell
RT   lines.";
RL   Br. J. Cancer 71:914-924(1995).
//