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Cellosaurus CH1 [Human ovarian carcinoma] (CVCL_4992)

[Text version]
Cell line name CH1 [Human ovarian carcinoma]
Accession CVCL_4992
Resource Identification Initiative To cite this cell line use: CH1 [Human ovarian carcinoma] (RRID:CVCL_4992)
Comments Problematic cell line: Contaminated. Shown to be a PA-1 derivative (PubMed=22710073).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00459.
Doubling time: 17 hours (PubMed=2653399).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro316Pro (c.948C>T); ClinVar=VCV000750727; Zygosity=Heterozygous (from parent cell line).
Disease Ovarian mixed germ cell tumor (NCIt: C8114)
Mixed germ cell tumor (ORDO: Orphanet_180234)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0479 (PA-1)
Children:
CVCL_X012 (CH1-cisR)CVCL_Y426 (CH1:RD1694)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX
D8S117914,15
D21S1129,31.2
FGA24
TH017,9
vWA15,17

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=2653399; DOI=10.1038/bjc.1989.108; PMCID=PMC2247140
Celia A. Hills, Lloyd R. Kelland, George Abel, Jan Siracky, Anne P. Wilson, Kenneth Reginald Harrap;
Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes.
Br. J. Cancer 59:527-534(1989)

PubMed=1892748; DOI=10.1038/bjc.1991.279; PMCID=PMC1977519
Prakash Mistry, Lloyd R. Kelland, George Abel, Sanjiv Sidhar, Kenneth Reginald Harrap;
The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines.
Br. J. Cancer 64:215-220(1991)

PubMed=1423261
Prakash Mistry, Lloyd R. Kelland, Swee Y. Loh, George Abel, Barry A. Murrer, Kenneth Reginald Harrap;
Comparison of cellular accumulation and cytotoxicity of cisplatin with that of tetraplatin and amminedibutyratodichloro(cyclohexylamine)platinum(IV) (JM221) in human ovarian carcinoma cell lines.
Cancer Res. 52:6188-6193(1992)

PubMed=1617660
Lloyd R. Kelland, Prakash Mistry, George Abel, Swee Y. Loh, Ciaran F. O'Neill, Barry A. Murrer, Kenneth Reginald Harrap;
Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates.
Cancer Res. 52:3857-3864(1992)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Kylie Louise Gorringe, Suet-Feung Chin, Paul D.P. Pharoah, Joanne M. Staines, Carla Oliveira, Paul A.W. Edwards, Carlos Caldas;
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4992
IGRhCellID; CH1
Biological sample resources BioSample; SAMN03151886
Chemistry resources ChEMBL-Cells; CHEMBL3307620
ChEMBL-Targets; CHEMBL614455
PubChem_Cell_line; CVCL_4992
Encyclopedic resources Wikidata; Q54811605
Gene expression databases GEO; GSM459735
GEO; GSM711723
GEO; GSM851914
Polymorphism and mutation databases Progenetix; CVCL_4992
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32