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Cellosaurus CH1-cisR (CVCL_X012)

[Text version]
Cell line name CH1-cisR
Synonyms CH1/cisR; CH1cisR; CH1Cis
Accession CVCL_X012
Resource Identification Initiative To cite this cell line use: CH1-cisR (RRID:CVCL_X012)
Comments Problematic cell line: Contaminated. Parent cell line (CH1) has been shown to be a PA-1 derivative.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00559.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Disease Ovarian mixed germ cell tumor (NCIt: C8114)
Mixed germ cell tumor (ORDO: Orphanet_180234)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4992 (CH1 [Human ovarian carcinoma])
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX
D8S117914,15
D18S5115,18
D21S1129,31.2
FGA24
TH017,9
vWA15,17

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=1617660
Lloyd R. Kelland, Prakash Mistry, George Abel, Swee Y. Loh, Ciaran F. O'Neill, Barry A. Murrer, Kenneth Reginald Harrap;
Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates.
Cancer Res. 52:3857-3864(1992)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_X012
Encyclopedic resources Wikidata; Q54811611
Gene expression databases GEO; GSM851915
Entry history
Entry creation17-Jul-2014
Last entry update10-Apr-2025
Version number23