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Cellosaurus CH1-cisR (CVCL_X012)

[Text version]
Cell line name CH1-cisR
Synonyms CH1/cisR; CH1cisR; CH1Cis
Accession CVCL_X012
Resource Identification Initiative To cite this cell line use: CH1-cisR (RRID:CVCL_X012)
Comments Problematic cell line: Contaminated. Parent cell line (CH1) has been shown to be a PA-1 derivative.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00559.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Disease Ovarian mixed germ cell tumor (NCIt: C8114)
Mixed germ cell tumor (ORDO: Orphanet_180234)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4992 (CH1 [Human ovarian carcinoma])
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX
D8S117914,15
D18S5115,18
D21S1129,31.2
FGA24
TH017,9
vWA15,17

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=1617660
Kelland L.R., Mistry P., Abel G., Loh S.Y., O'Neill C.F., Murrer B.A., Harrap K.R.
Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates.
Cancer Res. 52:3857-3864(1992)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_X012
Encyclopedic resources Wikidata; Q54811611
Gene expression databases GEO; GSM851915
Entry history
Entry creation17-Jul-2014
Last entry update10-Apr-2025
Version number23