Cellosaurus logo
expasy logo

Cellosaurus CH1:RD1694 (CVCL_Y426)

[Text][XML][JSON]
Cell line name CH1:RD1694
Accession CVCL_Y426
Resource Identification Initiative To cite this cell line use: CH1:RD1694 (RRID:CVCL_Y426)
Comments Problematic cell line: Contaminated. Parent cell line (CH1) has been shown to be a PA-1 derivative.
Selected for resistance to: ChEBI; CHEBI_5847; ICI D1694 (Tomudex; ZD1694).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Disease Ovarian mixed germ cell tumor (NCIt: C8114)
Mixed germ cell tumor (ORDO: Orphanet_180234)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4992 (CH1 [Human ovarian carcinoma])
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
Publications

PubMed=7537518; DOI=10.1038/bjc.1995.178; PMCID=PMC2033796
Ann L. Jackman, Lloyd R. Kelland, Rosemary Kimbell, Margaret Brown, William Gibson, G. Wynne Aherne, Anthea Hardcastle, Francis Thomas Boyle;
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Br. J. Cancer 71:914-924(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Y426
Encyclopedic resources Wikidata; Q54811612
Entry history
Entry creation07-Nov-2014
Last entry update19-Dec-2024
Version number16