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Cellosaurus MHCC97-H (CVCL_4972)

[Text version]
Cell line name MHCC97-H
Synonyms MHCC 97-H; MHCC-97H; MHCC97H
Accession CVCL_4972
Resource Identification Initiative To cite this cell line use: MHCC97-H (RRID:CVCL_4972)
Comments Part of: Liver Cancer Model Repository (LIMORE).
Population: Chinese.
Characteristics: High metastatic potential.
Doubling time: 28.79 hours (PubMed=31378681).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Phosphorylation.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Sequence variations
  • Mutation; HGNC; HGNC:14310; BRD7; Simple; p.Glu277Glyfs*18 (c.830_831delAG); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; HGNC:23177; KEAP1; Simple; p.Pro445Glnfs*13 (c.1334delC); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (PubMed=31378681).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4971 (MHCC97)
Children:
CVCL_6832 (HCCLM3)CVCL_E3I0 (HyCyte MHCC97-H-Luc)CVCL_VU22 (MHCC97-H c-Met shRNA)
CVCL_VU23 (MHCC97-H CD44s shRNA)CVCL_VU24 (MHCC97-H Scrm shRNA)CVCL_A9LY (MHCC97H-GFP-LC3)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): PubMed=31378681

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81812,13
D7S82010
D13S3178,11.3
D16S53912
TH019
TPOX8
vWA14

Run an STR similarity search on this cell line
Web pages Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/MHCC97H
Provider; BRICS; BRICS0079; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3893
Publications

PubMed=11819844; DOI=10.3748/wjg.v7.i5.630; PMCID=PMC4695564
Yan Li, Zhao-You Tang, Sheng-Long Ye, Yin-Kun Liu, Jie Chen, Qiong Xue, Jun Chen, Dong-Mei Gao, Wei-Hua Bao;
Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97.
World J. Gastroenterol. 7:630-636(2001)

PubMed=15048980; DOI=10.1002/pmic.200300653
Shi-Jian Ding, Yan Li, Xiao-Xia Shao, Hu Zhou, Rong Zeng, Zhao-You Tang, Qi-Chang Xia;
Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials.
Proteomics 4:982-994(2004)

PubMed=15146329; DOI=10.1007/s00432-004-0564-9
Yan Li, Bo Tian, Jiong Yang, Lei Zhao, Xin Wu, Sheng-Long Ye, Yin-Kun Liu, Zhao-You Tang;
Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics.
J. Cancer Res. Clin. Oncol. 130:460-468(2004)

PubMed=23505090; DOI=10.1002/hep.26402
Kai Wang, Ho Yeong Lim, Stephanie Shi, Jeeyun Lee, Shi-Bing Deng, Tao Xie, Zhou Zhu, Yu-Li Wang, David Pocalyko, Wei Jennifer Yang, Paul A. Rejto ...Show all 14 authors... , Mao Mao, Cheol-Keun Park, Jiang-Chun Xu; Show fewer authors
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=25690035; DOI=10.3390/ijms16024209; PMCID=PMC4346953
Miao-Miao Tian, Han Cheng, Zhi-Qiang Wang, Na Su, Ze-Xian Liu, Chang-Qing Sun, Bei Zhen, Xue-Chuan Hong, Yu Xue, Ping Xu;
Phosphoproteomic analysis of the highly-metastatic hepatocellular carcinoma cell line, MHCC97-H.
Int. J. Mol. Sci. 16:4209-4225(2015)

PubMed=25886575; DOI=10.1186/s12885-015-1166-4; PMCID=PMC4380258
Hien Dang, Steven N. Steinway, Wei Ding, Carl Bart Rountree Jr.;
Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma.
BMC Cancer 15:161.1-161.11(2015)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Stefano Caruso, Anna-Line Calatayud, Jill Pilet, Tiziana La Bella, Samia Rekik, Sandrine Imbeaud, Eric Letouze, Lea Meunier, Quentin Bayard, Nataliya Rohr-Udilova, Camille Peneau ...Show all 20 authors... , Bettina Grasl-Kraupp, Leanne de Koning, Berengere Ouine, Paulette Bioulac-Sage, Gabrielle Couchy, Julien Calderaro, Jean-Charles Nault, Jessica Zucman-Rossi, Sandra Rebouissou; Show fewer authors
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Zhi-Xin Qiu, Hong Li, Zheng-Tao Zhang, Zhen-Feng Zhu, Sheng He, Xu-Jun Wang, Peng-Cheng Wang, Jian-Jie Qin, Li-Ping Zhuang, Wei Wang, Fu-Bo Xie ...Show all 33 authors... , Ying Gu, Ke-Ke Zou, Chao Li, Chun Li, Chen-Hua Wang, Jin Cen, Xiao-Tao Chen, Ya-Jing Shu, Zhao Zhang, Lu-Lu Sun, Li-Hua Min, Yong Fu, Xiao-Wu Huang, Hui Lv, He Zhou, Yuan Ji, Zhi-Gang Zhang, Zhi-Qiang Meng, Xiao-Lei Shi, Hai-Bin Zhang, Yi-Xue Li, Li-Jian Hui; Show fewer authors
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

PubMed=32884988; DOI=10.1016/j.gendis.2019.12.008; PMCID=PMC7452459
Yu-Lin Lin, Yan Li;
Study on the hepatocellular carcinoma model with metastasis.
Genes Dis. 7:336-350(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4972
LIMORE; MHCC97H
Anatomy/cell type resources BTO; BTO_0004169
Chemistry resources ChEMBL-Cells; CHEMBL4295459
ChEMBL-Targets; CHEMBL4296470
PubChem_Cell_line; CVCL_4972
Encyclopedic resources Wikidata; Q54905533
Gene expression databases GEO; GSM501782
GEO; GSM936771
GEO; GSM1374675
GEO; GSM2551579
Proteomic databases PRIDE; PXD000529
PRIDE; PXD000533
PRIDE; PXD000535
PRIDE; PXD002453
PRIDE; PXD005291
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22