Cellosaurus cell line (CVCL

Comments

Population: Caucasian.
Doubling time: 20 hours (DOI=10.15369/sujms1989.9.45).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).

Disease

Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_8442 (MOBS-1)
Children:

CVCL_6832 (HCCLM3)	CVCL_F4IG (HyCyte MHCC97-H KO-hKLF4)	CVCL_F4Q5 (HyCyte MHCC97-H stable cell line for hPLAUR overexpression)
CVCL_E3I0 (HyCyte MHCC97-H-Luc)	CVCL_VU22 (MHCC97-H c-Met shRNA)	CVCL_VU23 (MHCC97-H CD44s shRNA)
CVCL_VU24 (MHCC97-H Scrm shRNA)	CVCL_A9LY (MHCC97H-GFP-LC3)

Sex of cell

Male

Age at sampling

37Y