Cellosaurus cell line MHCC97-H Scrm shRNA (CVCL

Cellosaurus MHCC97-H Scrm shRNA (CVCL_VU24)

Cross-references
Cell line name	MHCC97-H Scrm shRNA
Synonyms	MHCC97-H scrambled shRNA; MHCC97-H shRNA control
Accession	CVCL_VU24
Resource Identification Initiative	To cite this cell line use: MHCC97-H Scrm shRNA (RRID:CVCL_VU24)
Comments	Population: Chinese. Characteristics: Transfected with a scrambled shRNA, control cell line for MHCC97-H CD44s shRNA (Cellosaurus=CVCL_VU23) and MHCC97-H c-Met shRNA (Cellosaurus=CVCL_VU22). Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV). Omics: Transcriptome analysis by microarray.
Sequence variations	Mutation; HGNC; 14310; BRD7; Simple; p.Glu277Glyfs18 (c.830_831delAG); Zygosity=Unspecified (from parent cell line). Mutation; HGNC; 23177; KEAP1; Simple; p.Pro445Glnfs13 (c.1334delC); Zygosity=Unspecified (from parent cell line). Mutation; HGNC; 11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (from parent cell line).
Disease	Adult hepatocellular carcinoma (NCIt: C7956) Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_4972 (MHCC97-H)
Sex of cell	Male
Age at sampling	39Y
Category	Cancer cell line
Publications	PubMed=25886575; DOI=10.1186/s12885-015-1166-4 Dang H., Steinway S.N., Ding W., Rountree C.B. Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma. BMC Cancer 15:161.1-161.11(2015) PubMed=26000702; DOI=10.1371/journal.pone.0128159 Steinway S.N., Dang H., You H., Rountree C.B., Ding W. The EGFR/ERBB3 pathway acts as a compensatory survival mechanism upon c-Met inhibition in human c-Met+ hepatocellular carcinoma. PLoS ONE 10:E0128159-E0128159(2015)
Cell line databases/resources	cancercelllines; CVCL_VU24
Encyclopedic resources	Wikidata; Q95989436
Gene expression databases	GEO; GSM940340 GEO; GSM940341 GEO; GSM940342
Entry history
Entry creation	24-May-2019
Last entry update	05-Oct-2023
Version number	7