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Cellosaurus MHCC97-H c-Met shRNA (CVCL_VU22)

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Cell line name MHCC97-H c-Met shRNA
Synonyms MHCC97-H c-Met KD
Accession CVCL_VU22
Resource Identification Initiative To cite this cell line use: MHCC97-H c-Met shRNA (RRID:CVCL_VU22)
Comments Population: Chinese.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:7029; MET.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Transcriptomics; Microarray.
Sequence variations
  • Mutation; HGNC; HGNC:14310; BRD7; Simple; p.Glu277Glyfs*18 (c.830_831delAG); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:23177; KEAP1; Simple; p.Pro445Glnfs*13 (c.1334delC); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4972 (MHCC97-H)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=25886575; DOI=10.1186/s12885-015-1166-4; PMCID=PMC4380258
Hien Dang, Steven N. Steinway, Wei Ding, Carl Bart Rountree Jr.;
Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma.
BMC Cancer 15:161.1-161.11(2015)

PubMed=26000702; DOI=10.1371/journal.pone.0128159; PMCID=PMC4441360
Steven N. Steinway, Hien Dang, Hao You, Carl Bart Rountree Jr., Wei Ding;
The EGFR/ERBB3 pathway acts as a compensatory survival mechanism upon c-Met inhibition in human c-Met+ hepatocellular carcinoma.
PLoS ONE 10:e0128159.1-e0128159.16(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VU22
Encyclopedic resources Wikidata; Q95989434
Gene expression databases GEO; GSM940343
GEO; GSM940344
GEO; GSM940345
Entry history
Entry creation24-May-2019
Last entry update10-Apr-2025
Version number9