ID   MHCC97-H
AC   CVCL_4972
SY   MHCC 97-H; MHCC-97H; MHCC97H; MHCC 97-High metastatic
DR   BTO; BTO_0004169
DR   cancercelllines; CVCL_4972
DR   ChEMBL-Cells; CHEMBL4295459
DR   ChEMBL-Targets; CHEMBL4296470
DR   GEO; GSM501782
DR   GEO; GSM936771
DR   GEO; GSM1374675
DR   GEO; GSM2551579
DR   LIMORE; MHCC97H
DR   PRIDE; PXD000529
DR   PRIDE; PXD000533
DR   PRIDE; PXD000535
DR   PRIDE; PXD002453
DR   PRIDE; PXD005291
DR   PubChem_Cell_line; CVCL_4972
DR   Wikidata; Q54905533
RX   PubMed=11819844;
RX   PubMed=15048980;
RX   PubMed=15146329;
RX   PubMed=23505090;
RX   PubMed=25690035;
RX   PubMed=25886575;
RX   PubMed=31063779;
RX   PubMed=31378681;
RX   PubMed=32884988;
WW   Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/MHCC97H
WW   Provider; BRICS; BRICS0079; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3893
CC   Part of: Liver Cancer Model Repository (LIMORE).
CC   Population: Chinese.
CC   Characteristics: High metastatic potential (PubMed=11819844).
CC   Doubling time: 34.2 hours (PubMed=11819844); 28.79 hours (PubMed=31378681).
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Mutation; HGNC; HGNC:14310; BRD7; Simple; p.Glu277Glyfs*18 (c.830_831delAG); Zygosity=Unspecified (PubMed=31378681).
CC   Sequence variation: Mutation; HGNC; HGNC:23177; KEAP1; Simple; p.Pro445Glnfs*13 (c.1334delC); Zygosity=Unspecified (PubMed=31378681).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (PubMed=31378681).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; PTM; Phosphorylation.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
ST   Source(s): PubMed=31378681
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 8,11.3
ST   D16S539: 12
ST   D5S818: 12,13
ST   D7S820: 10
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 14
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4971 ! MHCC97
SX   Male
AG   39Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 23
CH   CVCL_6832 ! HCCLM3
CH   CVCL_E3I0 ! HyCyte MHCC97-H-Luc
CH   CVCL_VU22 ! MHCC97-H c-Met shRNA
CH   CVCL_VU23 ! MHCC97-H CD44s shRNA
CH   CVCL_VU24 ! MHCC97-H Scrm shRNA
CH   CVCL_A9LY ! MHCC97H-GFP-LC3
//
RX   PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724;
RA   Qiu, Zhi-Xin
RA   Li, Hong
RA   Zhang, Zheng-Tao
RA   Zhu, Zhen-Feng
RA   He, Sheng
RA   Wang, Xu-Jun
RA   Wang, Peng-Cheng
RA   Qin, Jian-Jie
RA   Zhuang, Li-Ping
RA   Wang, Wei
RA   Xie, Fu-Bo
RA   Gu, Ying
RA   Zou, Ke-Ke
RA   Li, Chao
RA   Li, Chun
RA   Wang, Chen-Hua
RA   Cen, Jin
RA   Chen, Xiao-Tao
RA   Shu, Ya-Jing
RA   Zhang, Zhao
RA   Sun, Lu-Lu
RA   Min, Li-Hua
RA   Fu, Yong
RA   Huang, Xiao-Wu
RA   Lv, Hui
RA   Zhou, He
RA   Ji, Yuan
RA   Zhang, Zhi-Gang
RA   Meng, Zhi-Qiang
RA   Shi, Xiao-Lei
RA   Zhang, Hai-Bin
RA   Li, Yi-Xue
RA   Hui, Li-Jian
RT   "A pharmacogenomic landscape in human liver cancers.";
RL   Cancer Cell 36:179-193.e11(2019).
//
RX   PubMed=11819844; DOI=10.3748/wjg.v7.i5.630; PMCID=PMC4695564;
RA   Li, Yan
RA   Tang, Zhao-You
RA   Ye, Sheng-Long
RA   Liu, Yin-Kun
RA   Chen, Jie
RA   Xue, Qiong
RA   Chen, Jun
RA   Gao, Dong-Mei
RA   Bao, Wei-Hua
RT   "Establishment of cell clones with different metastatic potential from
RT   the metastatic hepatocellular carcinoma cell line MHCC97.";
RL   World J. Gastroenterol. 7:630-636(2001).
//
RX   PubMed=25886575; DOI=10.1186/s12885-015-1166-4; PMCID=PMC4380258;
RA   Dang, Hien
RA   Steinway, Steven N.
RA   Ding, Wei
RA   Rountree, Carl Bart Jr.
RT   "Induction of tumor initiation is dependent on CD44s in c-Met(+)
RT   hepatocellular carcinoma.";
RL   BMC Cancer 15:161.1-161.11(2015).
//
RX   PubMed=15048980; DOI=10.1002/pmic.200300653;
RA   Ding, Shi-Jian
RA   Li, Yan
RA   Shao, Xiao-Xia
RA   Zhou, Hu
RA   Zeng, Rong
RA   Tang, Zhao-You
RA   Xia, Qi-Chang
RT   "Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H
RT   and MHCC97-L, with different metastasis potentials.";
RL   Proteomics 4:982-994(2004).
//
RX   PubMed=15146329; DOI=10.1007/s00432-004-0564-9;
RA   Li, Yan
RA   Tian, Bo
RA   Yang, Jiong
RA   Zhao, Lei
RA   Wu, Xin
RA   Ye, Sheng-Long
RA   Liu, Yin-Kun
RA   Tang, Zhao-You
RT   "Stepwise metastatic human hepatocellular carcinoma cell model system
RT   with multiple metastatic potentials established through consecutive in
RT   vivo selection and studies on metastatic characteristics.";
RL   J. Cancer Res. Clin. Oncol. 130:460-468(2004).
//
RX   PubMed=23505090; DOI=10.1002/hep.26402;
RA   Wang, Kai
RA   Lim, Ho Yeong
RA   Shi, Stephanie
RA   Lee, Jeeyun
RA   Deng, Shi-Bing
RA   Xie, Tao
RA   Zhu, Zhou
RA   Wang, Yu-Li
RA   Pocalyko, David
RA   Yang, Wei Jennifer
RA   Rejto, Paul A.
RA   Mao, Mao
RA   Park, Cheol-Keun
RA   Xu, Jiang-Chun
RT   "Genomic landscape of copy number aberrations enables the
RT   identification of oncogenic drivers in hepatocellular carcinoma.";
RL   Hepatology 58:706-717(2013).
//
RX   PubMed=32884988; DOI=10.1016/j.gendis.2019.12.008; PMCID=PMC7452459;
RA   Lin, Yu-Lin
RA   Li, Yan
RT   "Study on the hepatocellular carcinoma model with metastasis.";
RL   Genes Dis. 7:336-350(2020).
//
RX   PubMed=25690035; DOI=10.3390/ijms16024209; PMCID=PMC4346953;
RA   Tian, Miao-Miao
RA   Cheng, Han
RA   Wang, Zhi-Qiang
RA   Su, Na
RA   Liu, Ze-Xian
RA   Sun, Chang-Qing
RA   Zhen, Bei
RA   Hong, Xue-Chuan
RA   Xue, Yu
RA   Xu, Ping
RT   "Phosphoproteomic analysis of the highly-metastatic hepatocellular
RT   carcinoma cell line, MHCC97-H.";
RL   Int. J. Mol. Sci. 16:4209-4225(2015).
//
RX   PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001;
RA   Caruso, Stefano
RA   Calatayud, Anna-Line
RA   Pilet, Jill
RA   La Bella, Tiziana
RA   Rekik, Samia
RA   Imbeaud, Sandrine
RA   Letouze, Eric
RA   Meunier, Lea
RA   Bayard, Quentin
RA   Rohr-Udilova, Nataliya
RA   Peneau, Camille
RA   Grasl-Kraupp, Bettina
RA   de Koning, Leanne
RA   Ouine, Berengere
RA   Bioulac-Sage, Paulette
RA   Couchy, Gabrielle
RA   Calderaro, Julien
RA   Nault, Jean-Charles
RA   Zucman-Rossi, Jessica
RA   Rebouissou, Sandra
RT   "Analysis of liver cancer cell lines identifies agents with likely
RT   efficacy against hepatocellular carcinoma and markers of response.";
RL   Gastroenterology 157:760-776(2019).
//