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Cellosaurus SSP-25 (CVCL_4902)

[Text version]
Cell line name SSP-25
Synonyms SSP25
Accession CVCL_4902
Resource Identification Initiative To cite this cell line use: SSP-25 (RRID:CVCL_4902)
Comments Problematic cell line: Contaminated. Shown to be a ETK-1 derivative (RCB=RCB1293). Originally thought to originate from a 64 year old female patient with an intrahepatic cholangiocarcinoma.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JFCR45 cancer cell line panel.
Population: Japanese.
Doubling time: 64 hours (PubMed=9358283).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1206 (ETK-1)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001858; RCB=RCB1293

Penta D14
Penta E15

Run an STR similarity search on this cell line
Web pages https://cell.brc.riken.jp/en/rcb/rbessp-25_announce

PubMed=9358283; DOI=10.1007/s11626-997-0125-z
Enjoji M., Sakai H., Nawata H., Kajiyama K., Tsuneyoshi M.
Sarcomatous and adenocarcinoma cell lines from the same nodule of cholangiocarcinoma.
In Vitro Cell. Dev. Biol. Anim. 33:681-683(1997)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H., El-Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=31077409; DOI=10.1002/hep.30704
Sittithumcharee G., Suppramote O., Vaeteewoottacharn K., Sirisuksakun C., Jamnongsong S., Laphanuwat P., Suntiparpluacha M., Matha A., Chusorn P., Buraphat P., Kakanaporn C., Charngkaew K., Silsirivanit A., Korphaisarn K., Limsrichamrern S., Tripatara P., Pairojkul C., Wongkham S., Sampattavanich S., Okada S., Jirawatnotai S.
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Hepatology 70:1614-1630(2019)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007
Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y., Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S., Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

Cell line collections (Providers) RCB; RCB1293
Cell line databases/resources CLO; CLO_0050849
Cell_Model_Passport; SIDM00275
DepMap; ACH-001858
Biological sample resources BioSample; SAMN03472126
Encyclopedic resources Wikidata; Q54955717
Polymorphism and mutation databases Cosmic; 1187339
Cosmic; 1571786
Cosmic; 2629287
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number28