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Cellosaurus ETK-1 (CVCL_1206)

[Text version]
Cell line name ETK-1
Synonyms ETK1
Accession CVCL_1206
Resource Identification Initiative To cite this cell line use: ETK-1 (RRID:CVCL_1206)
Comments Part of: Biliary tract cancer cell line atlas.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Caution: Was incorrectly reported to be a SSP-25 contaminated cell line by Riken and thus also by ICLAC but it was later found out that SSP-25 was in fact contaminated by ETK-1 and not the other way around.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (Cosmic-CLP=906861; DepMap=ACH-002237).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.1
Native American0
East Asian, North74.88
East Asian, South17.31
South Asian0
European, North0.67
European, South4.05
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4902 (SSP-25)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=906861

Markers:
AmelogeninX
CSF1PO12
D5S81810
D7S82011
D13S31712
D16S53910,12
TH017
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; RCB; -; https://cell.brc.riken.jp/en/rcb/rbessp-25_announce
Publications

PubMed=9252136; DOI=10.1002/hep.510260206
Munechika Enjoji, Manabu Nakashima, Masanao Honda, Hironori Sakai, Hajime Nawata;
Hepatocytic phenotypes induced in sarcomatous cholangiocarcinoma cells treated with 5-azacytidine.
Hepatology 26:288-294(1997)

PubMed=10761710; DOI=10.1111/j.1349-7006.2000.tb00935.x; PMCID=PMC5926319
Munechika Enjoji, Manabu Nakashima, Makoto Nakamuta, Hajime Nawata;
Transforming growth factor-alpha induces the differentiation of sarcomatoid cholangiocarcinoma cells.
Jpn. J. Cancer Res. 91:223-230(2000)

PubMed=16643607; DOI=10.1111/j.1749-0774.2005.00007.x
Kaori Yoshino, Emi Iimura, Kaoru Saijo, Satsuki Iwase, Kiyoko Fukami, Tadao Ohno, Yuichi Obata, Yukio Nakamura;
Essential role for gene profiling analysis in the authentication of human cell lines.
Hum. Cell 19:43-48(2006)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

CLPUB00275
Sebastian Zach, Emrullah Birgin, Felix Ruckert;
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Abdulkadir Isidan, Ali Yenigun, Daiki Soma, Eric Aksu, Kevin Lopez, Yujin Park, Arthur Cross-Najafi, Ping Li, Debjyoti Kundu, Michael G. House, Sanjukta Chakraborty ...Show all 17 authors... , Shannon Glaser, Lindsey Kennedy, Heather Francis, Wen-Jun Zhang, Gianfranco D. Alpini, Burcin Ekser; Show fewer authors
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Prabhat Kattel, Lauren Kenney, Joshua Merritt, Ramzi Adil, Qi-Biao Wu, Yuan-Li Zhen ...Show all 39 authors... , Robert Morris, Johannes Kreuzer, Meena Kathiresan, Xcanda Ixchel Herrera Lopez, Haley Ellis, Ilaria G. Gritti, Lilian Lecorgne, Ines Farag, Alexandra Popa, William Shen, Hiroyuki Kato, Qin Xu, Eranga Roshan Balasooriya, Meng-Ju Wu, Saireudee Chaturantabut, Robin Kate Kelley, James Mark Cleary, Michael Scott Lawrence, David E. Root, Cyril Henri Benes, Vikram Deshpande, Dejan Juric, William Raj Sellers, Cristina Rosa Ferrone, Wilhelm Haas, Francisca Vazquez, Gad Getz, Nabeel M. Bardeesy; Show fewer authors
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
bioRxiv 2024:07.04.601970-07.04.601970(2024)

Cross-references
Cell line collections (Providers) RCB; RCB1289 - Discontinued
Cell line databases/resources CLO; CLO_0009831
cancercelllines; CVCL_1206
Cell_Model_Passport; SIDM00276
Cosmic-CLP; 906861
DepMap; ACH-002237
LINCS_LDP; LCL-1789
Biological sample resources BioSample; SAMN03151925
Chemistry resources ChEMBL-Cells; CHEMBL3308831
ChEMBL-Targets; CHEMBL2366116
GDSC; 906861
PharmacoDB; ETK1_348_2019
PubChem_Cell_line; CVCL_1206
Encyclopedic resources Wikidata; Q54832847
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669779
Polymorphism and mutation databases Cosmic; 906861
IARC_TP53; 21329
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number40