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Cellosaurus WIL2 NS (CVCL_2761)

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Cell line name WIL2 NS
Synonyms WIL2-NS; WIL-2NS; WIL-2-NS; WI-L2-NS; WI-L2 NS; WIL2NS; WIL2 Non-Secreting
Accession CVCL_2761
Resource Identification Initiative To cite this cell line use: WIL2 NS (RRID:CVCL_2761)
Comments Group: Hybridoma fusion partner cell line.
Group: Patented cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8155.
Population: Caucasian.
Characteristics: Does not secrete immunoglobulins.
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Sequence variations
HLA typing Source: IPD-IMGT/HLA=11561
Class II
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.61
East Asian, North0
East Asian, South0
South Asian1.47
European, North69.86
European, South28.06
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6544 (WIL2)
CVCL_Z045 (HO-323)CVCL_6416 (LTR228)CVCL_2762 (WIL2.NS.6TG)
CVCL_6742 (WTK-1)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-8155; Cosmic-CLP=1331049; ECACC=90112121; JCRB=JCRB9063; RCB=RCB2285

Penta D11,12
Penta E5,7
TH018,10 (JCRB=JCRB9063)
8,9.3 (ATCC=CRL-8155; Cosmic-CLP=1331049; ECACC=90112121; RCB=RCB2285)

Run an STR similarity search on this cell line

Coons T., Avner B.
Efficient cell fusion process.
Patent number US4806476, 21-Feb-1989

PubMed=1677771; DOI=10.1073/pnas.88.15.6652
Benjamin M.B., Potter H., Yandell D.W., Little J.B.
A system for assaying homologous recombination at the endogenous human thymidine kinase gene.
Proc. Natl. Acad. Sci. U.S.A. 88:6652-6656(1991)

PubMed=7798274; DOI=10.1016/S0021-9258(18)31687-9
Carrier F., Smith M.L., Bae I., Kilpatrick K.E., Lansing T.J., Chen C.-Y., Engelstein M., Friend S.H., Henner W.D., Gilmer T.M., Kastan M.B., Fornace A.J. Jr.
Characterization of human Gadd45, a p53-regulated protein.
J. Biol. Chem. 269:32672-32677(1994)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29892436; DOI=10.1098/rsos.172472
Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M., Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S., Satoh M., Shimizu N., Kohara A.
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=33198927; DOI=10.1016/j.mrgentox.2020.503236
Kasai F., Hirayama N., Kohara A.
TK6 genome profile compared with WIL2-NS: reference data to improve the reproducibility of genotoxicity studies.
Mutat. Res. 858:503236.1-503236.7(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections (Providers) ATCC; CRL-8155
ECACC; 90112121
RCB; RCB2285 - Discontinued
TKG; TKG 0374 - Discontinued
Cell line databases/resources CLO; CLO_0009601
CLO; CLO_0009604
CLDB; cl4717
cancercelllines; CVCL_2761
Cell_Model_Passport; SIDM01102
Cosmic-CLP; 1331049
DepMap; ACH-002316
Anatomy/cell type resources BTO; BTO:0001524
Biological sample resources BioSample; SAMN03471196
BioSample; SAMN03472416
Chemistry resources ChEMBL-Cells; CHEMBL3308012
ChEMBL-Targets; CHEMBL612810
GDSC; 1331049
PharmacoDB; WIL2NS_1661_2019
PubChem_Cell_line; CVCL_2761
Encyclopedic resources Wikidata; Q54994065
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827461
GEO; GSM1670575
GEO; GSM4288411
Polymorphism and mutation databases IARC_TP53; 4041
Progenetix; CVCL_2761
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number34