ID   WIL2 NS
AC   CVCL_2761
SY   WIL2-NS; WIL-2NS; WIL-2-NS; WI-L2-NS; WI-L2 NS; WIL2NS; WIL2 Non-Secreting
DR   BTO; BTO_0001524
DR   CLO; CLO_0009601
DR   CLO; CLO_0009604
DR   CLDB; cl4717
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-8155
DR   BioSample; SAMN03471196
DR   BioSample; SAMN03472416
DR   cancercelllines; CVCL_2761
DR   Cell_Model_Passport; SIDM01102
DR   ChEMBL-Cells; CHEMBL3308012
DR   ChEMBL-Targets; CHEMBL612810
DR   Cosmic-CLP; 1331049
DR   DepMap; ACH-002316
DR   ECACC; 90112121
DR   EGA; EGAS00001000978
DR   FANTOM5_SSTAR; 10808-111A7
DR   GDSC; 1331049
DR   GEO; GSM827461
DR   GEO; GSM1670575
DR   GEO; GSM4288411
DR   IARC_TP53; 4041
DR   IPD-IMGT/HLA; 11561
DR   JCRB; JCRB9063
DR   PharmacoDB; WIL2NS_1661_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_2761
DR   PubChem_Cell_line; CVCL_2761
DR   RCB; RCB2285
DR   TKG; TKG 0374
DR   Wikidata; Q54994065
RX   Patent=US4806476;
RX   PubMed=1677771;
RX   PubMed=7798274;
RX   PubMed=20215515;
RX   PubMed=27397505;
RX   PubMed=29892436;
RX   PubMed=30894373;
RX   PubMed=33198927;
RX   PubMed=35839778;
CC   Group: Hybridoma fusion partner cell line.
CC   Group: Patented cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8155.
CC   Population: Caucasian.
CC   Characteristics: Does not secrete immunoglobulins.
CC   HLA typing: DPA1*02:02:02 (IPD-IMGT/HLA=11561).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (PubMed=33198927).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Ile (c.711G>A); ClinVar=VCV000142714; Zygosity=Homozygous (PubMed=7798274; PubMed=33198927).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0.61%; East Asian, North=0%; East Asian, South=0%; South Asian=1.47%; European, North=69.86%; European, South=28.06% (PubMed=30894373).
CC   Discontinued: RCB; RCB2285; true.
CC   Discontinued: TKG; TKG 0374; probable.
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): ATCC=CRL-8155; Cosmic-CLP=1331049; ECACC=90112121; JCRB=JCRB9063; RCB=RCB2285
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 11,15
ST   D19S433: 14,16
ST   D21S11: 29
ST   D2S1338: 17,25
ST   D3S1358: 16
ST   D5S818: 12,13
ST   D7S820: 9,12
ST   D8S1179: 10,13
ST   F13A01: 6,7
ST   F13B: 10
ST   FESFPS: 11,12
ST   FGA: 22,24
ST   LPL: 9,10
ST   Penta D: 11,12
ST   Penta E: 5,7
ST   TH01: 8,9.3 (ATCC=CRL-8155; Cosmic-CLP=1331049; ECACC=90112121; RCB=RCB2285)
ST   TH01: 8,10 (JCRB=JCRB9063)
ST   TPOX: 8,11
ST   vWA: 17,20
DI   NCIt; C97074; Hereditary spherocytosis
DI   ORDO; Orphanet_822; Hereditary spherocytosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6544 ! WIL2
SX   Male
AG   5Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 36
CH   CVCL_Z045 ! HO-323
CH   CVCL_6416 ! LTR228
CH   CVCL_2762 ! WIL2.NS.6TG
CH   CVCL_6742 ! WTK-1
//
RX   PubMed=7798274; DOI=10.1016/S0021-9258(18)31687-9;
RA   Carrier, France
RA   Smith, Martin L.
RA   Bae, Insoo
RA   Kilpatrick, Katherine E.
RA   Lansing, Timothy J.
RA   Chen, Chaw-Yuan
RA   Engelstein, Marcy
RA   Friend, Stephen H.
RA   Henner, W. David
RA   Gilmer, Tona Morgan
RA   Kastan, Michael Barry
RA   Fornace, Albert J. Jr.
RT   "Characterization of human Gadd45, a p53-regulated protein.";
RL   J. Biol. Chem. 269:32672-32677(1994).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=33198927; DOI=10.1016/j.mrgentox.2020.503236;
RA   Kasai, Fumio
RA   Hirayama, Noriko
RA   Kohara, Arihiro
RT   "TK6 genome profile compared with WIL2-NS: reference data to improve
RT   the reproducibility of genotoxicity studies.";
RL   Mutat. Res. Genet. Toxicol. Environ. Mutagen. 858:503236.1-503236.7(2020).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=29892436; DOI=10.1098/rsos.172472; PMCID=PMC5990783;
RA   Shioda, Setsuko
RA   Kasai, Fumio
RA   Watanabe, Ken
RA   Kawakami, Kohei
RA   Ohtani, Azusa
RA   Iemura, Masashi
RA   Ozawa, Midori
RA   Arakawa, Akemi
RA   Hirayama, Noriko
RA   Kawaguchi, Eiko
RA   Tano, Tomoko
RA   Miyata, Sayaka
RA   Satoh, Motonobu
RA   Shimizu, Norio
RA   Kohara, Arihiro
RT   "Screening for 15 pathogenic viruses in human cell lines registered at
RT   the JCRB Cell Bank: characterization of in vitro human cells by viral
RT   infection.";
RL   R. Soc. Open Sci. 5:172472-172472(2018).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   Patent=US4806476;
RA   Coons, Teresa
RA   Avner, Barry
RT   "Efficient cell fusion process.";
RL   Patent number US4806476, 21-Feb-1989.
//
RX   PubMed=1677771; DOI=10.1073/pnas.88.15.6652; PMCID=PMC52146;
RA   Benjamin, Mark B.
RA   Potter, Huntington
RA   Yandell, David William
RA   Little, John Bertram
RT   "A system for assaying homologous recombination at the endogenous
RT   human thymidine kinase gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:6652-6656(1991).
//