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Cellosaurus D-17 (CVCL_1916)

[Text version]
Cell line name D-17
Synonyms D 17; D17; OSA-D-17
Accession CVCL_1916
Resource Identification Initiative To cite this cell line use: D-17 (RRID:CVCL_1916)
Comments Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Part of: FACC canine tumor cell line panel.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8468.
Doubling time: 22.2 hours (PubMed=22916246); 22 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; VGNC; 42508; KRAS; Simple; p.Glu63Lys (c.187G>A); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine osteosarcoma (NCIt: C120045)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Poodle.
Hierarchy Children:
CVCL_1917 (DAN)CVCL_1918 (DSDh)CVCL_1919 (DSN)
Sex of cell Female
Age at sampling 11Y
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Dog FHC2010231,239
Dog FHC2054156
Dog FHC2079275
Dog PEZ1127
Dog PEZ12263,290
Dog PEZ20172,180
Dog PEZ3127
Dog PEZ5103
Dog PEZ6179
Dog PEZ8232

Run an STR similarity search on this cell line

PubMed=19147538; DOI=10.1158/1541-7786.MCR-08-0347
Zhang J., Chen X., Kent M.S., Rodriguez C.O., Chen X.
Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor.
Mol. Cancer Res. 7:67-78(2009)

PubMed=21552385; DOI=10.7150/jca.2.262
Legare M.E., Bush J., Ashley A.K., Kato T., Hanneman W.H.
Cellular and phenotypic characterization of canine osteosarcoma cell lines.
J. Cancer 2:262-270(2011)

PubMed=21801068; DOI=10.2460/ajvr.72.8.1097
Stokol T., Daddona J.L., Mubayed L.S., Trimpert J., Kang S.
Evaluation of tissue factor expression in canine tumor cells.
Am. J. Vet. Res. 72:1097-1106(2011)

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=22849686; DOI=10.2460/ajvr.73.8.1252
Urbasic A.S., Hynes S., Somrak A.J., Contakos S., Rahman M.M., Liu J., MacNeill A.L.
Oncolysis of canine tumor cells by myxoma virus lacking the serp2 gene.
Am. J. Vet. Res. 73:1252-1261(2012)

PubMed=22916246; DOI=10.1371/journal.pone.0043355
Maeda J., Yurkon C.R., Fujisawa H., Kaneko M., Genet S.C., Roybal E.J., Rota G.W., Saffer E.R., Rose B.J., Hanneman W.H., Thamm D.H., Kato T.A.
Genomic instability and telomere fusion of canine osteosarcoma cells.
PLoS ONE 7:E43355-E43355(2012)

PubMed=23365669; DOI=10.1371/journal.pone.0054464
Wells J.W., Evans C.H., Scott M.C., Rutgen B.C., O'Brien T.D., Modiano J.F., Cvetkovic G., Tepic S.
Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.
PLoS ONE 8:E54464-E54464(2013)

PubMed=25190452; DOI=10.1186/s12917-014-0184-9
Pang L.Y., Argyle S.A., Kamida A., Morrison K.O., Argyle D.J.
The long-acting COX-2 inhibitor mavacoxib (Trocoxil TM) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro.
BMC Vet. Res. 10:184.1-184.11(2014)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=26842912; DOI=10.1111/vco.12197
Hartley G., Faulhaber E., Caldwell A., Coy J., Kurihara J., Guth A., Regan D., Dow S.
Immune regulation of canine tumour and macrophage PD-L1 expression.
Vet. Comp. Oncol. 15:534-549(2017)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

PubMed=33126659; DOI=10.3390/ani10111981
Modesto P., Fernandez J.L.C., Martini I., Zoccola R., Pugliano M.C., De Ciucis C.G., Goria M., Ferrari A., Razzuoli E.
Characterization of D-17 canine osteosarcoma cell line and evaluation of its ability to response to infective stressor used as alternative anticancer therapy.
Animals 10:1981.1-1981.16(2020)

PubMed=34079834; DOI=10.3389/fvets.2021.666838
Gola C., Giannuzzi D., Rinaldi A., Iussich S., Modesto P., Morello E., Buracco P., Aresu L., De Maria R.
Genomic and transcriptomic characterization of canine osteosarcoma cell lines: a valuable resource in translational medicine.
Front. Vet. Sci. 8:666838.1-666838.11(2021)

Cell line collections (Providers) ATCC; CCL-183
ATCC; CRL-6248 - Discontinued
BCRJ; 0276
ECACC; 89090403 - Discontinued
NCBI_Iran; C625
Cell line databases/resources CLO; CLO_0002655
CLO; CLO_0002664
CLO; CLO_0002665
CLO; CLO_0002666
CLDB; cl954
CLDB; cl955
TOKU-E; 1025
Anatomy/cell type resources BTO; BTO:0005354
Encyclopedic resources Wikidata; Q54817120
Gene expression databases GEO; GSM1974785
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number24