ID   D-17
AC   CVCL_1916
SY   D 17; D17; OSA-D-17
DR   BTO; BTO:0005354
DR   CLO; CLO_0002655
DR   CLO; CLO_0002664
DR   CLO; CLO_0002665
DR   CLO; CLO_0002666
DR   CLDB; cl954
DR   CLDB; cl955
DR   ATCC; CCL-183
DR   ATCC; CRL-6248
DR   BCRJ; 0276
DR   ECACC; 89090403
DR   GEO; GSM1974785
DR   IZSLER; BS TCL 15
DR   NCBI_Iran; C625
DR   TOKU-E; 1025
DR   Wikidata; Q54817120
RX   PubMed=19147538;
RX   PubMed=21552385;
RX   PubMed=21801068;
RX   PubMed=21908323;
RX   PubMed=22849686;
RX   PubMed=22916246;
RX   PubMed=23365669;
RX   PubMed=25190452;
RX   PubMed=26842912;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
RX   PubMed=33126659;
RX   PubMed=34079834;
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Part of: FACC canine tumor cell line panel.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8468.
CC   Doubling time: 22.2 hours (PubMed=22916246); 22 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; 42508; KRAS; Simple; p.Glu63Lys (c.187G>A); Zygosity=Heterozygous (PubMed=31175136).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Discontinued: ATCC; CRL-6248; true.
CC   Discontinued: ECACC; 89090403; probable.
CC   Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
CC   Breed/subspecies: Poodle.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 231,239
ST   Dog FHC2054: 156
ST   Dog FHC2079: 275
ST   Dog PEZ1: 127
ST   Dog PEZ3: 127
ST   Dog PEZ5: 103
ST   Dog PEZ6: 179
ST   Dog PEZ8: 232
ST   Dog PEZ12: 263,290
ST   Dog PEZ20: 172,180
DI   NCIt; C120045; Canine osteosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Female
AG   11Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 24
//
RX   PubMed=19147538; DOI=10.1158/1541-7786.MCR-08-0347;
RA   Zhang J., Chen X., Kent M.S., Rodriguez C.O., Chen X.-B.;
RT   "Establishment of a dog model for the p53 family pathway and
RT   identification of a novel isoform of p21 cyclin-dependent kinase
RT   inhibitor.";
RL   Mol. Cancer Res. 7:67-78(2009).
//
RX   PubMed=21552385; DOI=10.7150/jca.2.262;
RA   Legare M.E., Bush J., Ashley A.K., Kato T., Hanneman W.H.;
RT   "Cellular and phenotypic characterization of canine osteosarcoma cell
RT   lines.";
RL   J. Cancer 2:262-270(2011).
//
RX   PubMed=21801068; DOI=10.2460/ajvr.72.8.1097;
RA   Stokol T., Daddona J.L., Mubayed L.S., Trimpert J., Kang S.;
RT   "Evaluation of tissue factor expression in canine tumor cells.";
RL   Am. J. Vet. Res. 72:1097-1106(2011).
//
RX   PubMed=21908323; DOI=10.1177/1040638711408064;
RA   O'Donoghue L.E., Rivest J.P., Duval D.L.;
RT   "Polymerase chain reaction-based species verification and
RT   microsatellite analysis for canine cell line validation.";
RL   J. Vet. Diagn. Invest. 23:780-785(2011).
//
RX   PubMed=22849686; DOI=10.2460/ajvr.73.8.1252;
RA   Urbasic A.S., Hynes S., Somrak A.J., Contakos S., Rahman M.M., Liu J.,
RA   MacNeill A.L.;
RT   "Oncolysis of canine tumor cells by myxoma virus lacking the serp2
RT   gene.";
RL   Am. J. Vet. Res. 73:1252-1261(2012).
//
RX   PubMed=22916246; DOI=10.1371/journal.pone.0043355;
RA   Maeda J., Yurkon C.R., Fujisawa H., Kaneko M., Genet S.C.,
RA   Roybal E.J., Rota G.W., Saffer E.R., Rose B.J., Hanneman W.H.,
RA   Thamm D.H., Kato T.A.;
RT   "Genomic instability and telomere fusion of canine osteosarcoma
RT   cells.";
RL   PLoS ONE 7:E43355-E43355(2012).
//
RX   PubMed=23365669; DOI=10.1371/journal.pone.0054464;
RA   Wells J.W., Evans C.H., Scott M.C., Rutgen B.C., O'Brien T.D.,
RA   Modiano J.F., Cvetkovic G., Tepic S.;
RT   "Arginase treatment prevents the recovery of canine lymphoma and
RT   osteosarcoma cells resistant to the toxic effects of prolonged
RT   arginine deprivation.";
RL   PLoS ONE 8:E54464-E54464(2013).
//
RX   PubMed=25190452; DOI=10.1186/s12917-014-0184-9;
RA   Pang L.Y., Argyle S.A., Kamida A., Morrison K.O., Argyle D.J.;
RT   "The long-acting COX-2 inhibitor mavacoxib (Trocoxil TM) has
RT   anti-proliferative and pro-apoptotic effects on canine cancer cell
RT   lines and cancer stem cells in vitro.";
RL   BMC Vet. Res. 10:184.1-184.11(2014).
//
RX   PubMed=26842912; DOI=10.1111/vco.12197;
RA   Hartley G., Faulhaber E., Caldwell A., Coy J., Kurihara J., Guth A.,
RA   Regan D.P., Dow S.W.;
RT   "Immune regulation of canine tumour and macrophage PD-L1 expression.";
RL   Vet. Comp. Oncol. 15:534-549(2017).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689;
RA   Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.;
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:E0156689-E0156689(2016).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//
RX   PubMed=33126659; DOI=10.3390/ani10111981;
RA   Modesto P., Fernandez J.L.C., Martini I., Zoccola R., Pugliano M.C.,
RA   De Ciucis C.G., Goria M., Ferrari A., Razzuoli E.;
RT   "Characterization of D-17 canine osteosarcoma cell line and evaluation
RT   of its ability to response to infective stressor used as alternative
RT   anticancer therapy.";
RL   Animals 10:1981.1-1981.16(2020).
//
RX   PubMed=34079834; DOI=10.3389/fvets.2021.666838;
RA   Gola C., Giannuzzi D., Rinaldi A., Iussich S., Modesto P., Morello E.,
RA   Buracco P., Aresu L., De Maria R.;
RT   "Genomic and transcriptomic characterization of canine osteosarcoma
RT   cell lines: a valuable resource in translational medicine.";
RL   Front. Vet. Sci. 8:666838.1-666838.11(2021).
//