Cellosaurus logo
expasy logo

Cellosaurus DSDh (CVCL_1918)

[Text][XML][JSON]
Cell line name DSDh
Accession CVCL_1918
Resource Identification Initiative To cite this cell line use: DSDh (RRID:CVCL_1918)
Comments Group: Retrovirus packaging cell line.
Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:94890; Dhfr (Note=With p.Leu23Arg; methotrexate-resistant).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03399; Avian reticuloendotheliosis virus env.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03360; Avian reticuloendotheliosis virus gag-pol.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; VGNC; VGNC:42508; KRAS; Simple; p.Glu63Lys (c.187G>A); Zygosity=Heterozygous (from parent cell line).
Disease Canine osteosarcoma (NCIt: C120045)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Poodle; VBO=VBO_0201048.
Hierarchy Parent: CVCL_1916 (D-17)
Sex of cell Female
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=2304918; DOI=10.1073/pnas.87.4.1556; PMCID=PMC53514
Wei-Shou Hu, Howard Martin Temin;
Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination.
Proc. Natl. Acad. Sci. U.S.A. 87:1556-1560(1990)

Cross-references
Cell line collections (Providers) ATCC; CRL-2131
Cell line databases/resources CLO; CLO_0002828
Encyclopedic resources Wikidata; Q54831449
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number17