ID   DSDh
AC   CVCL_1918
DR   CLO; CLO_0002828
DR   ATCC; CRL-2131
DR   Wikidata; Q54831449
RX   PubMed=2304918;
CC   Group: Retrovirus packaging cell line.
CC   Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
CC   Sequence variation: Mutation; VGNC; VGNC:42508; KRAS; Simple; p.Glu63Lys (c.187G>A); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:94890; Dhfr (Note=With p.Leu23Arg; methotrexate-resistant).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03399; Avian reticuloendotheliosis virus env.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03360; Avian reticuloendotheliosis virus gag-pol.
CC   Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
CC   Breed/subspecies: Poodle; VBO=VBO_0201048.
DI   NCIt; C120045; Canine osteosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_1916 ! D-17
SX   Female
AG   11Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 17
//
RX   PubMed=2304918; DOI=10.1073/pnas.87.4.1556; PMCID=PMC53514;
RA   Hu W.-S., Temin H.M.;
RT   "Genetic consequences of packaging two RNA genomes in one retroviral
RT   particle: pseudodiploidy and high rate of genetic recombination.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:1556-1560(1990).
//