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Cellosaurus Peer (CVCL_1913)

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Cell line name Peer
Synonyms PEER
Accession CVCL_1913
Resource Identification Initiative To cite this cell line use: Peer (RRID:CVCL_1913)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: ~50-60 hours (DSMZ=ACC-6); ~40-50 hours (Note=Lot 06202003), ~39 hours (Note=Lot 10012019) (JCRB=JCRB0830).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:8064; NUP214; Name(s)=NUP214-ABL1; Note=NUP214 exon 34 fused to ABL1 exon 2 (PubMed=15361874; PubMed=35354797; DSMZ=ACC-6).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (PubMed=22675565; DepMap=ACH-000519).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Heterozygous (PubMed=10071127; PubMed=22675565; DepMap=ACH-000519).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*23:01,24:02
HLA-BB*35:02,44:03
HLA-CC*04:01,04:01
Class II
HLA-DQDQA1*01:02,01:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.73
Native American0.87
East Asian, North2.76
East Asian, South0.35
South Asian9.54
European, North10.64
European, South72.11
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1081 (BE-13)CVCL_E8UC (ICLU-T)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-6; JCRB=JCRB0830; RCB=RCB1879; TKG=TKG 0377

Markers:
AmelogeninX
CSF1PO12
D2S133820
D3S135815
D5S81812
D7S82010,12
D8S117915
D13S31711,14 (DSMZ=ACC-6; RCB=RCB1879; TKG=TKG 0377)
14 (JCRB=JCRB0830)
D16S5398,13
D18S5111,15
D19S43313
D21S1128,33.2
FGA24
Penta D11,13
Penta E13,15
TH017,8
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/2016/07/06/peer/
Info; Wikipedia; -; https://de.wikipedia.org/wiki/Peer_(Zelllinie)
Publications

PubMed=14768698; DOI=10.1002/ijc.2910250604
Zohar Ravid, Natan Goldblum, Rina Zaizov Marx, Michael Schlesinger, Tamar Kertes, Jun Minowada, Winston Verbi, Melvyn Francis Greaves;
Establishment and characterization of a new leukaemic T-cell line (Peer) with an unusual phenotype.
Int. J. Cancer 25:705-710(1980)

PubMed=6181032; DOI=10.1016/0198-8859(82)90037-4
Ruth Rabinowitz, J. Weinstock, Ehud J. Margalioth, Hannah Ben-Bassat, Michael Schlesinger;
Antigens specific for human T-lymphocytes detected by xenoantisera to HD-MAR cells: their differential expression on various T-cell lines.
Hum. Immunol. 4:219-228(1982)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2523930; DOI=10.4049/jimmunol.142.10.3634
Rene de Waal Malefyt, Balbino Alarcon, Hans Yssel, Jaime Sancho, Atsushi Miyajima, Cox Pieter Terhorst, Hergen Spits, Jan E. de Vries;
Introduction of T cell receptor (TCR)-alpha cDNA has differential effects on TCR-gamma delta/CD3 expression by PEER and Lyon-1 cells.
J. Immunol. 142:3634-3642(1989)

PubMed=2241089
Liliane Massaad-Massade, Anne-Marie Venuat, Yorghos Remvikos, Bernard Dutrillaux;
Revision of the chromosome anomalies of the T-cell malignant cell line PEER.
Ann. Genet. 33:76-78(1990)

PubMed=1373528
Da-Shuhn Duan, Wayne Smith, Wolfgang Sadee, Morton J. Cowan;
Characterization of three T-lymphoid cell lines with distinct sensitivities to deoxyadenosine plus deoxycoformycin.
Thymus 19:1-11(1992)

PubMed=8127147
Mats Heyman, Dan Grander, Karen Brondum-Nielsen, Britta Cederblad, Yie Liu, Bo Xu, Stefan Einhorn;
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Reiner Siebert, Christoph P. Willers, Alexander Schramm, Alexander Fossa, Irina M. Gana Dresen, Michael J. Uppenkamp, Mohammad Resa Nowrousian, Siegfried Seeber, Bertram Opalka;
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x
Laura Borgonovo-Brandter, Mats Heyman, Omid Rasool, Y. Liu, Dan Grander, Stefan Einhorn;
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Eur. J. Haematol. 56:313-318(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Renate Burger, Thomas E. Hansen-Hagge, Hans Gunther Drexler, Martin Gramatzki;
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Machiko Kawamura, Hiroaki Ohnishi, Shu-Xia Guo, Xiao-Ming Sheng, Masayoshi Minegishi, Ryoji Hanada, Keizo Horibe, Teruaki Hongo, Yasuhiko Kaneko, Fumio Bessho, Masayoshi Yanagisawa ...Show all 13 authors... , Takao Sekiya, Yasuhide Hayashi; Show fewer authors
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=15361874; DOI=10.1038/ng1425
Carlos Graux, Jan Cools, Cindy Melotte, Hilmar Quentmeier, Adolfo A. Ferrando, Ross Levine, Joris R. Vermeesch, Michel Stul, Binita Dutta, Nancy Boeckx, Andre Bosly ...Show all 24 authors... , Pierre Heimann, Anne Uyttebroeck, Nicole Mentens, Riet Somers, Roderick A.F. MacLeod, Hans Gunther Drexler, Alfred Thomas Look, Dwight Gary Gilliland, Lucienne Michaux, Peter Vandenberghe, Iwona Wlodarska, Peter Marynen, Anne Hagemeijer; Show fewer authors
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.
Nat. Genet. 36:1084-1089(2004)

PubMed=15472075; DOI=10.1126/science.1102160
Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee, John P. Morris 4th, Lewis B. Silverman, Cheryll Sanchez-Irizarry, Stephen Charles Blacklow, Alfred Thomas Look, Jon Christopher Aster;
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Yorick Sandberg, Brenda Verhaaf, Ellen J. van Gastel-Mol, Ingrid L.M. Wolvers-Tettero, John De Vos, Roderick A.F. MacLeod, Jeroen G. Noordzij, Willem A. Dik, Jack J.M. van Dongen, Anton W. Langerak;
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=17308084; DOI=10.1158/0008-5472.CAN-06-2615
Stefan Nagel, Michaela Scherr, Alexander Kel, Klaus Hornischer, Gregory E. Crawford, Maren Kaufmann, Corinna Meyer, Hans Gunther Drexler, Roderick A.F. MacLeod;
Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.
Cancer Res. 67:1461-1471(2007)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22675565; DOI=10.1371/journal.pone.0038463; PMCID=PMC3366948
Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Gianfelici, Ellen Geerdens, Roel Vandepoel, Daphnie Pauwels, Michael Porcu, Idoya Lahortiga, Vanessa Brys, Wilhelm Gerhard Dirks, Hilmar Quentmeier ...Show all 17 authors... , Jacqueline Cloos, Harry Cuppens, Anne Uyttebroeck, Peter Vandenberghe, Jan Cools, Stein Aerts; Show fewer authors
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:e38463.1-e38463.11(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Paivi Ostling ...Show all 17 authors... , Olli-Pekka Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtio, Mattias Vesterlund, Rozbeh Jafari; Show fewer authors
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-6
JCRB; JCRB0830
NCBI_Iran; C511
RCB; RCB1879
TKG; TKG 0377
Cell line databases/resources CLO; CLO_0008416
CLO; CLO_0050081
CLDB; cl4115
cancercelllines; CVCL_1913
Cell_Model_Passport; SIDM00991
DepMap; ACH-000519
DSMZCellDive; ACC-6
LINCS_LDP; LCL-2062
Anatomy/cell type resources BTO; BTO_0001959
Biological sample resources BioSample; SAMN01821654
BioSample; SAMN03472523
BioSample; SAMN03473496
BioSample; SAMN10988124
Chemistry resources PharmacoDB; PEER_1261_2019
Encyclopedic resources Wikidata; Q2067085
Experimental variables resources EFO; EFO_0022420
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887512
GEO; GSM888594
GEO; GSM5137737
Polymorphism and mutation databases Cosmic; 721704
Cosmic; 801731
Cosmic; 933548
Cosmic; 998727
Cosmic; 1037685
Cosmic; 1115597
Cosmic; 1118460
Cosmic; 1130238
Cosmic; 1281382
Cosmic; 1330494
Cosmic; 1375591
Cosmic; 1524813
Cosmic; 1641383
Cosmic; 1760530
Cosmic; 2165707
Cosmic; 2361369
Cosmic; 2602908
IARC_TP53; 10566
IARC_TP53; 30193
LiGeA; CCLE_494
Progenetix; CVCL_1913
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number41